SNP information rs2241880

Research and publications:

  17200669   A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.

  17435756   Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.

  17447842   Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4.

  17455206   Confirmation of the role of ATG16L1 as a susceptibility gene for Crohn's disease.

  17484864   A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5.

  17684544   Systematic association mapping identifies NELL1 as a novel IBD disease gene.

  17894849   IL23R R381Q and ATG16L1 T300A were strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease.

  17924341   Fine mapping versus replication in whole-genome association studies.

  18047540   ATG16L1 and IL23R are associated with inflammatory bowel diseases but not with celiac disease in the Netherlands.

  18088053   The autophagy gene ATG16L1 influences disease susceptibility and location, but not the onset of Crohn's disease in childhood in Northern Europe.

  18162085   ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are closely associated with susceptibility to Crohn's disease in the German population.

  18200510   CARD15 and IL23R influence Crohn's disease susceptibility but not disease phenotype in a Brazilian population.

  18366306   Classification of genetic profiles of Crohn's disease: focus on the ATG16L1 gene.

  18438405   Signal replication from recent Crohn's disease studies reveals previously unknown loci in ulcerative colitis.

  18495612   [Correlation of the autophagosome gene ATG16L1 polymorphism and inflammatory bowel disease].

  18499543   ATG16L1 and IL23 receptor (IL23R) genes are associated with disease susceptibility in Hungarian CD patients.

  18698678   Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult- and pediatric-onset inflammatory bowel disease in Italy.

  18715515   Lack of evidence linking primary sclerosing cholangitis and primary biliary cirrhosis with Crohn's disease risk alleles in Polish patients.

  18852889   Intracellular pathogen autophagy impairment induced by the Crohn's disease-associated ATG16L1 variant.

  18853133   Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.

  18985712   The autophagy gene ATG16L1, but not IRGM, is associated with Crohn's disease in Canadian children.

  19174780   Confirmation of multiple susceptibility loci for Crohn's disease in a large Dutch-Belgian cohort.

  19185283   Searching for genotype-phenotype structure: using hierarchical log-linear models in Crohn disease.

  19337756   ATG16L1 T300A polymorphism and susceptibility to Crohn's disease: data from 13,022 cases and 17,532 controls.

  19491842   Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach.

  19575361   Role of ATG16L1 Thr300Ala polymorphism in inflammatory bowel disease: a Study in the Spanish population and a meta-analysis.

  19590455   Association of IL23R p.381Gln and ATG16L1 p.197Ala with Crohn disease in the Czech population.

  19659808   Autophagy 16-like allele 1 rs2241880 G is associated with Crohn's disease in German children.

  19683022   Lack of association of NKX2-3, IRGM, and ATG16L1 inflammatory bowel disease susceptibility variants with celiac disease.

  19916168   Genome-wide association studies--a summary for the clinical gastroenterologist.

  20014019   Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease.

  20066736   Interaction of major susceptibility alleles to inflammatory bowel disease in patients with Crohn's disease.

  20082483   NOD2, IL23R and ATG16L1 polymorphisms in Lithuanian patients with inflammatory bowel disease.

  20155851   NOD2 status and human ileal gene expression.

  20195480   Cannabinoid receptor 1 (CNR1) polymorphism 1359 G/A modulates susceptibility to ulcerative colitis and the Crohn's disease phenotype.

  20222171   T300A polymorphism of ATG16L1 and susceptibility to inflammatory bowel diseases: a meta-analysis.

  20380008   Polymorphism of the NOD2/CARD15, ATG16L1 and IL23R genes and the onset of Crohn's disease in childhood.

  20395867   Do Crohn's disease-associated autophagy genes ATG16L1 and IRGM play a role in granuloma formation?

  20454450   Evidence that STAT4 is a common autoimmune gene: rs7574865 is associated with Crohn's disease of the colon and early onset of the disease.

  20485703   A replication and meta-analysis of 13,000 cases determines the risk of interleukin-23 receptor and autophagy-related 16-like variants 1 in Crohn's disease.

  20570966   Nonsecretory fucosyltransferase 2 (FUT2) status is associated with Crohn's disease.

  20839241   Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases.

  20846217   Association of linear growth impairment in pediatric Crohn's disease and known growth locus: a pilot study.

  20857526   High prevalence of viable Mycobacterium avium subspecies paratuberculosis in Crohn's disease.

  20886065   Molecular reclassification of Crohn's disease by cluster analysis of genetic variants.

  21079743   Interaction of Crohn's disease susceptibility genes in an Australian pediatric cohort.

  21152001   The association of 1q32 and STAT3 variants with ankylosing spondylitis suggests genetic overlap with Crohn's disease.

  21206965   Polymorphisms of IL23R, NOD2/CARD15, ATG16L1 and PHOX2B in a group of patients with Crohn's disease and correlation with subphenotypes.

  21209938   NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common variants of the Crohn's disease susceptibility gene.

  21333900   The role of genetics in IBS

  21427131   Improved Crohn's disease risk prediction using a multilocus approach.

  21487504   Immunopathogenesis of inflammatory bowel disease.

  21513755   ATG16L1 gene polymorphisms are associated with palmoplantar pustulosis.

  21548950   Evaluation of 22 genetic variants with risk for Crohn's disease in an Ashkenazi Jewish population: a case-control study.

  21559399   CEACAM6 gene variants in inflammatory bowel disease.

  21673517   ATG16L1 polymorphisms are associated with NOD2-induced hyperinflammation.

  21730793   The influence of risk alleles for Crohn's disease and smoking on the location of the disease.

  21734790   NOD2 and ATG16L1 polymorphisms influence monocyte response in Crohn's disease.

  21830272   Different and overlapping genetic loci in Crohn's disease and ulcerative colitis: correlation with pathogenesis.

  21858542   Sex differences in disease risk from reported genome-wide association study findings.

  21936032   Digesting the genetics of inflammatory bowel disease: insights from studies of autophagy risk genes.

  21978003   Autophagy modulates the Mycobacterium tuberculosis-induced cytokine response.

  22115380   Predicting the occurrence of complications in Crohn's disease using phenotype and genotype parameters when making a diagnosis.

  22219593   The role of genetics in the diagnosis and prognosis of Crohn's disease.

  22242114   The role of osteopontin haplotypes (OPN/SPP1) in susceptibility to Crohn's disease.

  22253516   The role of genetics in the diagnosis and prognosis of Crohn's disease.

  22275320   Pattern recognition receptor and autophagy gene variants are associated with antimicrobial antibody production in Crohn's disease.

  22346247   The role of ATG16L, NOD2 and IL23R in the pathogenesis of Crohn's disease.

  22412388   Genome-wide scanning of Crohn's disease of Ashkenazi Jews suggests new susceptibility loci.

  22457781   Variants in the PTPN2 gene are associated with susceptibility to both Crohn's disease and ulcerative colitis, supporting a common genetic basis for the disease.

  22479607   Analysis of IL12B gene variants in inflammatory bowel disease.

  22573572   Phenotype-genotype profiles in Crohn's disease predicted by genetic markers in autophagy-related genes (GOIA II study).

  22719818   Inflammatory bowel diseases phenotype, C. difficile and NOD2 genotype are associated with shifts in human ileum associated microbial composition.

  22879892   Polymorphisms in autophagy genes and susceptibility to tuberculosis.

  22938532   Sequencing and analysis of a South Asian-Indian personal genome.

  23300620   Genotype/phenotype analysis of 53 genetic polymorphisms associated with Crohn's disease.

  23300802   Polymorphisms modulating PTGER4 expression in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites.

  23365659   IRGM variants and susceptibility to inflammatory bowel disease in the German population.

  23535819   Lack of association of the autophagy-related gene polymorphism ATG16L1 rs2241880 in RA predisposition.

  23725363   Prediction of complex Crohn's disease and surgery: phenotypes, genetics, serology and psychological characteristics of a population-based cohort.

  23964099   Genomic ATG16L1 compromises allele-limited Paneth cell ER stress in quiescent Crohn's disease.

  24012056   Association of Egr-1 and autophagy-related gene polymorphism in men with chronic obstructive pulmonary disease.

  24223725   Intestinal DMBT1 expression is modulated by IL23R variants associated with Crohn's disease and a DMBT1 variant that affects the binding of the transcription factors CREB1 and ATF-2.

  24522266   The detection of Mycobacterium avium subspecies paratuberculosis in patients with Crohn's disease is not associated with the presence of single nucleotide polymorphisms rs2241880 (ATG16L1) and rs10045431 (IL12B).

  24553140   The Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3.

  24627602   ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes from patients with Crohn's disease.

  24739953   Role of genetic variants of autophagy genes in susceptibility for non-medullary thyroid cancer and patients outcome.

  24791954   Association of autophagy-related 16-like 1 (ATG16L1) gene polymorphism with sepsis severity in patients with sepsis and ventilator-associated pneumonia.

  24918007   Clinical and genetic factors predicting response to therapy in patients with Crohn's disease.

  25048429   Association of IL23R and ATG16L1 with susceptibility to Crohn's disease in a Chinese population.

  25369137   A multilocus genetic study in a cohort of Italian SLE patients confirms the association with STAT4 gene and describes a new association with HCP5 gene.

  25587358   Complex host genetics influence the microbiome in inflammatory bowel disease.

  25664588   Autophagy in Helicobacter pylori Infection and Related Gastric Cancer.

  25731871   Deep resequencing of 131 genes associated with Crohn's disease in pooled DNA confirmed three known variants and identified eight new variants.

  25738374   ATG16L1 and IL23R variants and genetic susceptibility to Crohn's disease: mode of inheritance based on a meta-analysis of genetic association studies.

  25944217   Genetic Polymorphisms in Autophagy-Associated Genes in Korean Children With Early-Onset Crohn Disease.

  26030385   Polymorphisms in autophagy genes are associated with paget disease of bone.

  26043189   Genetic determinants of quantitative traits associated with cardiovascular disease risk.

  26226011   The ATG16L1 (rs2241880) polymorphism associated with Crohn's disease reduces SHIP gene expression and activity in humans.

  27128681   Genetic Variation in Autophagy-Related Genes Influences the Risk and Phenotype of Buruli Ulcer.