SNP information rs17879961

Research and publications:

  10617473   Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome.

  12533788   Mutations in CHEK2 associated with prostate cancer risk.

  15239132   CHEK2 variant I157T may be associated with increased breast cancer risk.

  15492928   CHEK2 is a multiorgan cancer susceptibility gene.

  16816021   CHEK2 I157T associates with familial and sporadic colorectal cancer.

  17085682   A large germline deletion in the Chek2 kinase gene is associated with an increased risk of prostate cancer.

  17517688   Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study.

  19442246   The associations of sequence variants in DNA-repair and cell-cycle genes with cancer risk: genotype-phenotype correlations.

  20729852   A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.

  21514219   Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence

  23946381   Genetic variants associated with colorectal cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence.

  24244489   A common variant in the SIAH2 locus is associated with estrogen receptor-positive breast cancer in the Chinese Han population.

  24599715   Variants in the ATM-CHEK2-BRCA1 axis determine genetic predisposition and clinical presentation of papillary thyroid carcinoma.

  24728327   Germline variation in cancer-susceptibility genes in a healthy, ancestrally diverse cohort: implications for individual genome sequencing.

  24880342   Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer.

  25741868   Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

  26264438   Search for new loci and low-frequency variants influencing glioma risk by exome-array analysis.

  26506619   Association of Germline CHEK2 Gene Variants with Risk and Prognosis of Non-Hodgkin Lymphoma.

  26510858   Patients with a High Polygenic Risk of Breast Cancer do not have An Increased Risk of Radiotherapy Toxicity.

  26845104   Improving performance of multigene panels for genomic analysis of cancer predisposition.

  27230571   Different dietary patterns and reduction of lung cancer risk: A large case-control study in the U.S.

  27392074   The Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case-Control Study.

  27424552   Genomics era and complex disorders: Implications of GWAS with special reference to coronary artery disease, type 2 diabetes mellitus, and cancers.

  27438779   Polygenic risk score is associated with increased disease risk in 52 Finnish breast cancer families.

  27632928   Rare variants in BRCA2 and CHEK2 are associated with the risk of urinary tract cancers.

  27747004   Association of CHEK2 polymorphisms with the efficacy of platinum-based chemotherapy for advanced non-small-cell lung cancer in Chinese never-smoking women.

  28779002   Rare, protein-truncating variants in ATM, CHEK2 and PALB2, but not XRCC2, are associated with increased breast cancer risks.

  29382703   Common Genetic Variation and Breast Cancer Risk-Past, Present, and Future.

  29688369   The SNPcurator: literature mining of enriched SNP-disease associations.

  30089490   Thyroid cancers of follicular origin in a genomic light: in-depth overview of common and unique molecular marker candidates.

  30672594   Germline BRCA2 K3326X and CHEK2 I157T mutations increase risk for sporadic pancreatic ductal adenocarcinoma.

  31398194   Computational analysis of high-risk SNPs in human CHK2 gene responsible for hereditary breast cancer: A functional and structural impact.

  31428572   Mutation Spectrum of Cancer-Associated Genes in Patients With Early Onset of Colorectal Cancer.

  31629678   Re-evaluating genetic variants identified in candidate gene studies of breast cancer risk using data from nearly 280,000 women of Asian and European ancestry.

  31780696   Germline variants in cancer genes in high-risk non-BRCA patients from Puerto Rico.

  32104210   Inherited lung cancer: a review.

  32695137   Workflow for the Implementation of Precision Genomics in Healthcare.

  33778923   The association of three DNA repair genes polymorphisms on the frequency of chromosomal alterations detected by fluorescence in situ hybridization.

  35127508   The Mutational Landscape of Early-Onset Breast Cancer: A Next-Generation Sequencing Analysis.

  35197637   Genetic associations of protein-coding variants in human disease.