SNP information rs11465804

Research and publications:

  17447842   Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4.

  17786191   rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: a combined analysis of IL23R, CARD15 and OCTN1/2 variants.

  17952073   Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.

  18047539   Association between genetic variants in the IL-23R gene and early-onset Crohn's disease: results from a case-control and family study among Canadian children.

  18369459   A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.

  18383363   Association of interleukin-23 receptor variants with ankylosing spondylitis.

  18587394   Genome-wide association identifies more than 30 different susceptibility loci for Crohn's disease.

  18758464   Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.

  19122664   Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.

  19175939   IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease.

  19189980   Association between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case-control study and meta-analysis of published series.

  19408013   Strategies and issues in the detection of pathway enrichment in genome-wide association studies

  19468064   Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.

  19557189   Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions

  19918037   Association of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosis.

  20018022   Replication of recently identified associated single-nucleotide polymorphisms from six autoimmune diseases in Genetic Analysis Workshop 16 rheumatoid arthritis data.

  20177049   Insufficient evidence for association of NOD2/CARD15 or other inflammatory bowel disease-associated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantation.

  20228799   Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

  20454450   Evidence that STAT4 is a common autoimmune gene: rs7574865 is associated with Crohn's disease of the colon and early onset of the disease.

  20485703   A replication and meta-analysis of 13,000 cases determines the risk of interleukin-23 receptor and autophagy-related 16-like variants 1 in Crohn's disease.

  20505004   On safari to Random Jungle: a fast implementation of Random Forests for high-dimensional data.

  20570966   Nonsecretory fucosyltransferase 2 (FUT2) status is associated with Crohn's disease.

  20722033   The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.

  20805105   Synthetic associations in the context of genome-wide association scan signals

  20827186   Defining genetic risk for graft-versus-host disease and mortality following allogeneic hematopoietic stem cell transplantation

  21152001   The association of 1q32 and STAT3 variants with ankylosing spondylitis suggests genetic overlap with Crohn's disease.

  21304977   An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.

  21559399   CEACAM6 gene variants in inflammatory bowel disease.

  21752155   Genetic susceptibility to inflammation and colonic transit in lower functional gastrointestinal disorders: preliminary analysis.

  21830272   Different and overlapping genetic loci in Crohn's disease and ulcerative colitis: correlation with pathogenesis.

  21846945   Association of interleukin 23 receptor gene with sarcoidosis.

  21852963   Pervasive sharing of genetic effects in autoimmune disease.

  22089529   Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis.

  22154103   Genetic variability in IL23R and risk of colorectal adenoma and colorectal cancer.

  22242114   The role of osteopontin haplotypes (OPN/SPP1) in susceptibility to Crohn's disease.

  22269043   Clinical predictors of inflammatory bowel disease in a genetically well-defined Caucasian population.

  22275320   Pattern recognition receptor and autophagy gene variants are associated with antimicrobial antibody production in Crohn's disease.

  22293688   1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data.

  22440928   Perianal Crohn's disease: prognostic factors and genotype-phenotype correlations.

  22457781   Variants in the PTPN2 gene are associated with susceptibility to both Crohn's disease and ulcerative colitis, supporting a common genetic basis for the disease.

  22479607   Analysis of IL12B gene variants in inflammatory bowel disease.

  22770979   Presence of multiple independent effects in risk loci of common complex human diseases.

  22972380   Investigation of genetic risk factors for chronic adult diseases for association with preterm birth

  22984500   Association of single nucleotide polymorphisms of IL23R and IL17 with ulcerative colitis risk in a Chinese Han population.

  23112570   Suggestive association between PLA2G12A single nucleotide polymorphism rs2285714 and response to anti-vascular endothelial growth factor therapy in patients with exudative age-related macular degeneration.

  23300802   Polymorphisms modulating PTGER4 expression in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites.

  23365659   IRGM variants and susceptibility to inflammatory bowel disease in the German population.

  23725363   Prediction of complex Crohn's disease and surgery: phenotypes, genetics, serology and psychological characteristics of a population-based cohort.

  24223725   Intestinal DMBT1 expression is modulated by IL23R variants associated with Crohn's disease and a DMBT1 variant that affects the binding of the transcription factors CREB1 and ATF-2.

  25133031   Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature.

  25328554   Systemic Sclerosis is a Complex Disease Associated Mainly with Immune Regulatory and Inflammatory Genes.

  26106387   Pathogenesis of Systemic Sclerosis.

  26626589   The variations of IL-23R are associated with susceptibility and severe clinical forms of pulmonary tuberculosis in Chinese Uygurs.

  26678098   Association of interleukin-23 receptor gene polymorphisms with susceptibility to Crohn's disease: a meta-analysis.

  26861312   Association between Genetic Polymorphisms and Response to Anti-TNFs in Patients with Inflammatory Bowel Disease.

  27156530   Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility.

  27902482   IL-23R mutation is associated with ulcerative colitis: A systemic review and meta-analysis.

  28603427   Pharmacogenetics in inflammatory bowel disease: understanding treatment response and personalizing therapeutic strategies.

  29193749   Clinical Implementation of Pharmacogenetic Testing in a Hospital of the Spanish National Health System: Strategy and Experience Over 3 Years.

  29228965   Genetic polymorphism in ATG16L1 gene is associated with adalimumab use in inflammatory bowel disease.

  29691688   Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: an updated meta-analysis.

  29944013   Complex role of IL-23R polymorphisms on ankylosing spondylitis: a meta-analysis.

  30322951   Association between cytokine gene polymorphisms and ankylosing spondylitis susceptibility: a systematic review and meta-analysis.

  31052430   Genetic Studies of Inflammatory Bowel Disease-Focusing on Asian Patients.

  31615448   Candidate single nucleotide polymorphisms of irritable bowel syndrome: a systemic review and meta-analysis.

  31648514   Evaluation of interleukin-23 receptor (IL-23R) gene polymorphisms and serum IL-23 levels in patients with psoriasis.

  32823753   Current Insights in Genetics of Sarcoidosis: Functional and Clinical Impacts.

  32984386   Personalizing Treatment in IBD: Hype or Reality in 2020? Can We Predict Response to Anti-TNF?

  34539646   Targeting the Interleukin-23/Interleukin-17 Inflammatory Pathway: Successes and Failures in the Treatment of Axial Spondyloarthritis.

  35379982   Progress in the genetics of uveitis.