SNP information rs10758669

Research and publications:

  18006699   Host genetic variation contributes to phenotypic diversity in myeloproliferative disorders.

  19287382   JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms.

  20228799   Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

  20805105   Synthetic associations in the context of genome-wide association scan signals

  21297633   Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

  21304977   An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.

  21425313   Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9.

  21752155   Genetic susceptibility to inflammation and colonic transit in lower functional gastrointestinal disorders: preliminary analysis.

  21852963   Pervasive sharing of genetic effects in autoimmune disease.

  22190364   Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.

  22269120   Investigation of JAK2, STAT3 and CCR6 polymorphisms and their gene-gene interactions in inflammatory bowel disease.

  22359581   Th17-related genes and celiac disease susceptibility.

  23028907   Limited evidence for parent-of-origin effects in inflammatory bowel disease associated loci.

  23611997   JAK1, but not JAK2 and STAT3, confers susceptibility to Vogt-Koyanagi-Harada (VKH) syndrome in a Han Chinese population.

  24244878   Fibrogenesis and fibrosis in inflammatory bowel diseases: Good and bad side of same coin?

  24864251   rs744166 polymorphism of the STAT3 gene is associated with risk of gastric cancer in a Chinese population.

  25133031   Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature.

  25526816   Genetic association between germline JAK2 polymorphisms and myeloproliferative neoplasms in Hong Kong Chinese population: a case-control study.

  27156530   Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility.

  27664279   JAK2 Disease-Risk Variants Are Gain of Function and JAK Signaling Threshold Determines Innate Receptor-Induced Proinflammatory Cytokine Secretion in Macrophages.

  27668286   Characterization of candidate genes in inflammatory bowel disease-associated risk loci.

  27965977   Lack of Association between Genetic Polymorphisms of JAK-STAT Signaling Pathway Genes and Acute Anterior Uveitis in Han Chinese.

  18587394   Genome-wide association identifies more than 30 different susceptibility loci for Crohn's disease.

  19068216   Investigation of Crohn's disease risk loci in ulcerative colitis further determines their molecular relatedness.

  20109474   Genetic drivers of chronic inflammation: single nucleotide polymorphisms in the STAT-JAK pathway, DNA damage susceptibility and Crohn's disease in a New Zealand population.

  20570966   Nonsecretory fucosyltransferase 2 (FUT2) status is associated with Crohn's disease.

  21102463   Genome-wide meta-analysis increases the number of confirmed susceptibility loci for Crohn's disease to 71.

  21152001   The association of 1q32 and STAT3 variants with ankylosing spondylitis suggests genetic overlap with Crohn's disease.

  21730793   The influence of risk alleles for Crohn's disease and smoking on the location of the disease.

  22065112   JAK2 rs10758669 variant in Crohn's disease: alteration of the intestinal barrier as one of the mechanisms of action.

  22508400   Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) identifies common susceptibility loci with rheumatoid arthritis.

  23300620   Genotype/phenotype analysis of 53 genetic polymorphisms associated with Crohn's disease.

  24385239   JAK2 rs10758669 polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: a meta-analysis.

  27303667   Genetic influences on the development of fibrosis in Crohn's disease.

  29967744   Association of Crohn's disease-associated chromosome 1q32 with ankylosing spondylitis is independent of bowel symptoms and fecal calprotectin.