Upload the DNA data file of the test

23andMe, AncestryDNA, FamilyTreeDNA, MyHeritage

and get an enhanced
personalized health report
free without registration

Files accepted .txt, .csv, .zip, .csv.gz

File data is not stored on the server

SNP information rs5918


Normal allele: TT

The A2 allele of the platelet-specific alloantigen system is encoded by rs5918(C), it is associated with increased risk of myocardial infarction, heart disease and resistance to the blood thinning properties of aspirin.

Polymorphism rs5918 is related to topics like this:

Heart attack genetic

Genetic predisposition, also referred to as familial predisposition, is a crucial risk factor for...

Factor 5 blood clotting disorder

Thrombophilia, an increased tendency to form abnormal blood clots that can obstruct blood vessels,...

Research and publications:

  2565345   The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing.

  7570918   Gene frequencies of the five major human platelet antigens in African American, white, and Korean populations.

  8598867   A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis.

  8667943   Clues to the death of an Olympic champion.

  8838346   A monoclonal antibody (SZ21) specific for platelet GPIIIa distinguishes P1A1 from P1A2.

  9700201   Array-based multiplex analysis of candidate genes reveals two independent and additive genetic risk factors for myocardial infarction in the Finnish population.

  10583927   Higher prevalence of GPIIIa PlA2 polymorphism in siblings of patients with premature coronary heart disease.

  11723016   Pl(A2) polymorphism of beta(3) integrins is associated with enhanced thrombin generation and impaired antithrombotic action of aspirin at the site of microvascular injury.

  17107626   Comparison of PrASE and Pyrosequencing for SNP Genotyping

  17264806   Integrin beta3 Leu33Pro polymorphism and risk of hip fracture: 25 years follow-up of 9233 adults from the general population.

  17827388   Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma.

  17999363   Multifactor dimensionality reduction-phenomics: a novel method to capture genetic heterogeneity with use of phenotypic variables.

  18035074   Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction.

  18045240   Immunologic and structural analysis of eight novel domain-deletion beta3 integrin peptides designed for detection of HPA-1 antibodies.

  18513389   New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background

  18936436   Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994

  19131662   A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients

  19263529   Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach

  19330901   Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study

  19559392   A candidate gene association study of 77 polymorphisms in migraine

  19588468   Association and gene-gene interaction of SLC6A4 and ITGB3 in autism.

  19786296   Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction.

  19876733   The Leu33Pro polymorphism in the ITGB3 gene does not modify BRCA1/2-associated breast or ovarian cancer risks: results from a multicenter study among 15,542 BRCA1 and BRCA2 mutation carriers.

  20031584   Genetics of atherothrombotic and lacunar stroke

  20406466   Genetic variants associated with fasting blood lipids in the U.S. population: Third National Health and Nutrition Examination Survey

  20472470   Impact of COX-2 rs5275 and rs20417 and GPIIIa rs5918 polymorphisms on 90-day ischemic stroke functional outcome: a novel finding.

  20610812   The genetics of normal platelet reactivity.

  20938371   Platelet aggregation pathway.

  21054877   Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994

  21102624   Family-based association study of ITGB3 in autism spectrum disorder and its endophenotypes.

  21353223   Association of the platelet GPIIb/IIIa polymorphism with atherosclerotic plaque morphology: the Atherosclerosis Risk in Communities (ARIC) Study.

  21658613   Host genetics in follicular lymphoma.

  21659962   Replication of genetic associations in the inflammation, complement, and coagulation pathways with intraventricular hemorrhage in LBW preterm neonates

  21894447   Are centenarians genetically predisposed to lower disease risk?

  21919968   Validation of genetic variants associated with early acute rejection in kidney allograft transplantation.

  21921273   Cardiovascular pharmacogenomics.

  21955043   Validation of single nucleotide polymorphisms associated with acute rejection in kidney transplant recipients using a large multi-center cohort.

  22015659   Mean platelet volume and integrin alleles correlate with levels of integrins α(IIb)β(3) and α(2)β(1) in acute coronary syndrome patients and normal subjects.

  22017886   Autism risk assessment in siblings of affected children using sex-specific genetic scores.

  22133274   Polymorphisms of PAI-1 and platelet GP Ia may associate with impairment of renal function and thrombocytopenia in Puumala hantavirus infection.

  22270286   Preimplantation genetic diagnosis for fetal neonatal alloimmune thrombocytopenia due to antihuman platelet antigen maternal antibodies.

  22551325   No association of nineteen COX-2 gene variants to preclinical markers of atherosclerosis The Cardiovascular Risk in Young Finns Study.

  23451109   Genetic variation of ITGB3 is associated with asthma in Chinese Han children.

  23533563   Novel risk factors for premature peripheral arterial occlusive disease in non-diabetic patients: a case-control study.

  23628433   Genetic association and gene-gene interaction analyses suggest likely involvement of ITGB3 and TPH2 with autism spectrum disorder (ASD) in the Indian population.

  23810503   Comparison of high-resolution melting analysis, TaqMan Allelic discrimination assay, and sanger sequencing for Clopidogrel efficacy genotyping in routine molecular diagnostics.

  24944790   Screening for 392 polymorphisms in 141 pharmacogenes.

  25025995   Genetic risk of restenosis after percutaneous coronary interventions in the era of drug-eluting stents.

  25280596   The role of β3 integrin gene variants in Autism Spectrum Disorders--diagnosis and symptomatology.

  25360888   Genetic determinants of on-aspirin platelet reactivity: focus on the influence of PEAR1.

  25361584   Subgroups at high risk for ischaemic heart disease:identification and validation in 67 000 individuals from the general population.

  25741868   Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

  25897256   Personalized antiplatelet and anticoagulation therapy: applications and significance of pharmacogenomics.

  26261166   A preliminary study of inherited thrombophilic risk factors in different clinical manifestations of venous thromboembolism in central Iran.

  26322220   A comprehensive meta-analysis of common genetic variants in autism spectrum conditions.

  26440977   Integrin beta-3 genetic variants and risk of venous thromboembolism in colorectal cancer patients.

  26587841   Candidate Gene Analysis of Mortality in Dialysis Patients.

  26592644   Detection of human genome mutations associated with pregnancy complications using 3-D microarray based on macroporous polymer monoliths.

  26689941   Genetic variants associated with colorectal brain metastases susceptibility and survival.

  27589735   A Genomics-Based Model for Prediction of Severe Bioprosthetic Mitral Valve Calcification.

  27616475   Gene variants as risk factors for gastroschisis.

  27965976   Identification of ITGA2B and ITGB3 Single-Nucleotide Polymorphisms and Their Influences on the Platelet Function.

  28086795   Atherosclerotic and thrombotic genetic and environmental determinants in Egyptian coronary artery disease patients: a pilot study.

  28190175   Lack of association between integrin α(v)β(3) gene polymorphisms and hemorrhagic fever with renal syndrome in Han Chinese from Hubei, China.

  28905013   Common rs5918 (PlA1/A2) polymorphism in the ITGB3 gene and risk of coronary artery disease.

  29038237   The Gain-of-Function Integrin β3 Pro33 Variant Alters the Serotonin System in the Mouse Brain.

  29461866   The Prognostic Value of Combinations of Genetic Polymorphisms in the ITGB3, ITGA2, and CYP2C19*2 Genes in Predicting Cardiovascular Outcomes After Coronary Bypass Grafting.

  30081812   [Possible Genetic Predictors of Cardiovascular Complications After Coronary Artery Bypass Surgery].

  30143348   Myocardial infarction before and after the age of 45: Possible role of platelet receptor polymorphisms.

  30384452   Investigating Association of rs5918 Human Platelets Antigen 1 and rs1800790 Fibrinogen β Chain as Critical Players with Recurrent Pregnancy Loss.

  30830114   [Role of and genes polymorphisms in the pathogenesis of stroke of the Erzya population in the Republic of Mordovia].

  31095065   CENTRAL RETINAL VEIN OCCLUSION IN OTHERWISE HEALTHY CHILDREN AND ADOLESCENTS: Association With Multigenetic Variants of Thrombophilia.

  31364314   Genetics of recurrent pregnancy loss among Iranian population.

  31615384   [Hemostatic Gene Polymorphisms in Acute Coronary Syndrome with Nonobstructive Coronary Atherosclerosis].

  34104098   β3-integrin Leu33Pro gain of function variant does not modulate inflammatory activity in human derived macrophages in diabetes.

  34356593   PlA2 Polymorphism of Platelet Glycoprotein IIb/IIIa and C677T Polymorphism of Methylenetetrahydrofolate Reductase (MTHFR), but Not Factor V Leiden and Prothrombin G20210A Polymorphisms, Are Associated with More Severe Forms of Legg-Calvé-Perthes

  35002407   The association between two genetic polymorphisms in ITGB3 and increase risk of venous thromboembolism in cancer patients in Eastern Province of Saudi Arabia.

  35629166   Association of Genetic Polymorphisms with Complications of Implanted LVAD Devices in Patients with Congestive Heart Failure: A Kazakhstani Study.

CGRP migraine

Migraine affects a significant portion of the adult population in most countries, with a higher...

Memory genes

Despite being often overlooked, the brain possesses an impressive ability to restrict the creation...

Genetics and high blood pressure

Abnormally high blood pressure in the arteries, which transport blood from the heart to the rest of...