Normal allele: CC
Increases the likelihood of autism by 1.42 times. Association between the locus of high autism risk and social communication spectrum phenotypes in the general population.
Polymorphism rs4307059 is related to topics like this:
Research and publications:
19404256 Common genetic variants on 5p14.1 associate with autism spectrum disorders.
19456320 A genome-wide association study of autism reveals a common novel risk locus at 5p14.1.
19812673 A genome-wide linkage and association scan reveals novel loci for autism.
19959718 Whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux.
20634369 Association between a high-risk autism locus on 5p14 and social communication spectrum phenotypes in the general population.
20838614 Traits contributing to the autistic spectrum.
21078308 Do common variants play a role in risk for autism? Evidence and theoretical musings.
21438146 Dysfunctional gene splicing as a potential contributor to neuropsychiatric disorders.
21556359 Novel autism subtype-dependent genetic variants are revealed by quantitative trait and subphenotype association analyses of published GWAS data.
21784875 Large-scale methylation domains mark a functional subset of neuronally expressed genes.
22739633 The association of rs4307059 and rs35678 markers with autism spectrum disorders is replicated in Italian families.
22843504 Individual common variants exert weak effects on the risk for autism spectrum disorders.
22846907 Analysis of four genes involved in the neurodevelopment shows association of rs4307059 polymorphism in the cadherin 9/10 region with completed suicide.
22849751 Autism genetics: searching for specificity and convergence.
23620727 The evidence for association of ATP2B2 polymorphisms with autism in Chinese Han population.
23715297 Haplotype structure enables prioritization of common markers and candidate genes in autism spectrum disorder.
23840741 A Novel Stratification Method in Linkage Studies to Address Inter- and Intra-Family Heterogeneity in Autism.
25108264 Genomics in neurological disorders.
25360606 MACROD2 gene associated with autistic-like traits in a general population sample.
26395558 A de novo microdeletion of SEMA5A in a boy with autism spectrum disorder and intellectual disability.
27417655 Lack of replication of previous autism spectrum disorder GWAS hits in European populations.
27503586 Brain enhancer activities at the gene-poor 5p14.1 autism-associated locus.
30610940 Replication of previous GWAS hits suggests the association between rs4307059 near MSNP1AS and autism in a Chinese Han population.
33076578 Genetic Risk of Autism Spectrum Disorder in a Pakistani Population.