SNP information rs3807306

Research and publications:

  15657875   Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.

  17189288   Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation.

  18285424   Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations.

  18288123   Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans.

  18668568   Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients.

  19109131   Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo.

  19440200   Identification of new SLE-associated genes with a two-step Bayesian study design

  19854706   Association of IRF5 polymorphisms with activation of the interferon alpha pathway.

  19956648   Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases.

  20112359   Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients.

  20112383   Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus.

  20453842   Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

  20479942   Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap.

  20603721   Genome-wide association filtering using a highly locus-specific transmission/disequilibrium test.

  20605164   Gene-gene-sex interaction in cytokine gene polymorphisms revealed by serum interferon alpha phenotype in juvenile dermatomyositis.

  20861862   Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus-6 infection.

  21156761   A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.

  21627826   Cis-regulation of IRF5 expression is unable to fully account for systemic lupus erythematosus association: analysis of multiple experiments with lymphoblastoid cell lines.

  22088620   IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus.

  22162633   Activation of type I interferon pathway in systemic lupus erythematosus: association with distinct clinical phenotypes.

  22544929   IRF5 risk polymorphisms contribute to interindividual variance in pattern recognition receptor-mediated cytokine secretion in human monocyte-derived cells.

  22674082   Brief Report: IRF5 systemic lupus erythematosus risk haplotype is associated with asymptomatic serologic autoimmunity and progression to clinical autoimmunity in mothers of children with neonatal lupus.

  22936693   Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants.

  23251221   Interferon regulatory factor 5 in the pathogenesis of systemic lupus erythematosus.

  23941291   Identification of three new cis-regulatory IRF5 polymorphisms: in vitro studies.

  23971939   IRF5, but not TLR4, DEFB1, or VDR, is associated with the risk of ulcerative colitis in a Han Chinese population.

  24205329   Detection of regulatory SNPs in human genome using ChIP-seq ENCODE data.

  24943672   Prediction of response to interferon therapy in multiple sclerosis.

  24968232   Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells.

  25130328   Interferon regulatory factor 3 as key element of the interferon signature in plasmacytoid dendritic cells from systemic lupus erythematosus patients: novel genetic associations in the Mexican mestizo population.

  25564941   Association between genetic polymorphisms of the interferon regulatory factor 5 (IRF5) gene and Malaysian patients with Crohn's disease.

  27478803   A Bioinformatics Approach to Prioritize Single Nucleotide Polymorphisms in TLRs Signaling Pathway Genes.

  27506385   Predicting gene targets from integrative analyses of summary data from GWAS and eQTL studies for 28 human complex traits.

  27863251   Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells.

  28185859   Association of IRF5 polymorphisms with increased risk for systemic lupus erythematosus in population of Crete, a southern-eastern European Greek island.

  29375210   Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection.

  29423720   Association of interferon regulatory factor 5 (IRF5) gene polymorphisms with juvenile idiopathic arthritis.

  30168487   The IRF5 rs2004640 (G/T) polymorphism is not a genetic risk factor for systemic lupus erythematosus in population from south India.

  30176312   Genetic variants of interferon regulatory factor 5 associated with the risk of community-acquired pneumonia.

  30770922   Genetics and epigenetics of primary Sjögren's syndrome.

  32328064   Autoimmunity-Related Risk Variants in PTPN22 and CTLA4 Are Associated With ME/CFS With Infectious Onset.

  34751274   Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19.

  35088123   Genetics of rheumatoid arthritis.