SNP information rs11540652

Research and publications:

  1565143   Prevalence and spectrum of germline mutations of the p53 gene among patients with sarcoma.

  1683921   p53 germline mutations in Li-Fraumeni syndrome.

  9569050   Mutations in residues of TP53 that directly contact DNA predict poor outcome in human primary breast cancer.

  10797439   Investigation of germline PTEN, p53, p16(INK4A)/p14(ARF), and CDK4 alterations in familial glioma.

  11139324   Germline TP53 alterations in Finnish breast cancer families are rare and occur at conserved mutation-prone sites.

  15004724   Mutant p53 expression enhances drug resistance in a hepatocellular carcinoma cell line.

  16489069   The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer.

  17606709   Transcriptional functionality of germ line p53 mutants influences cancer phenotype.

  18511570   Molecular basis of the Li-Fraumeni syndrome: an update from the French LFS families.

  18798306   Construction of a high resolution linkage disequilibrium map to evaluate common genetic variation in TP53 and neural tube defect risk in an Irish population.

  19556618   High frequency of de novo mutations in Li-Fraumeni syndrome.

  21264207   Detection of somatic mutations by high-resolution DNA melting (HRM) analysis in multiple cancers.

  23161690   The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis.

  24381225   Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice.

  24487413   Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients.

  24641375   Prognostic significance of TP53 mutations and single nucleotide polymorphisms in acute myeloid leukemia: a case series and literature review.

  24651012   Mutant p53 in cancer: new functions and therapeutic opportunities.

  25032700   NCI-60 whole exome sequencing and pharmacological CellMiner analyses.

  25105660   Computational screening and molecular dynamic simulation of breast cancer associated deleterious non-synonymous single nucleotide polymorphisms in TP53 gene.

  25157968   Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

  26619011   Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

  26716509   Integrative bioinformatic analyses of an oncogenomic profile reveal the biology of endometrial cancer and guide drug discovery.

  26824983   Multiple gene sequencing for risk assessment in patients with early-onset or familial breast cancer.

  26845104   Improving performance of multigene panels for genomic analysis of cancer predisposition.

  29525983   Identification of novel mutations in FFPE lung adenocarcinomas using DEPArray sorting technology and next-generation sequencing.

  30744407   Single nucleotide recognition using a probes-on-carrier DNA chip.

  30867801   Genetic alterations of triple negative breast cancer (TNBC) in women from Northeastern Mexico.

  31188922   Mutational landscape of head and neck squamous cell carcinomas in a South Asian population.

  32000721   Pattern of nucleotide variants of TP53 and their correlation with the expression of p53 and its downstream proteins in a Sri Lankan cohort of breast and colorectal cancer patients.

  32867815   A deep analysis using panel-based next-generation sequencing in an Ecuadorian pediatric patient with anaplastic astrocytoma: a case report.

  33076847   Discovering the molecular differences between right- and left-sided colon cancer using machine learning methods.

  34203389   Targeted Sequencing of Taiwanese Breast Cancer with Risk Stratification by the Concurrent Genes Signature: A Feasibility Study.

  34239995   Mutations of METTL3 predict response to neoadjuvant chemotherapy in muscle-invasive bladder cancer.

  34529667   Clinical and molecular characterization of patients fulfilling Chompret criteria for Li-Fraumeni syndrome in Southern Brazil.

  34676052   TP53 mutations determined by targeted NGS in breast cancer: a case-control study.

  35127508   The Mutational Landscape of Early-Onset Breast Cancer: A Next-Generation Sequencing Analysis.