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SNP information rs1048661

Normal allele: GG

The LOXL1 gene variant is associated with primary open-angle and primary closed-angle glaucoma, exfoliative glaucoma, and cataracts.

Polymorphism rs1048661 is related to topics like this:

Glaucoma


Research and publications:

  17690259   Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.

  18037624   Ancestral LOXL1 variants are associated with pseudoexfoliation in Caucasian Australians but with markedly lower penetrance than in Nordic people.

  18201684   Lysyl oxidase-like 1 polymorphisms and exfoliation syndrome in the Japanese population.

  18223248   The LOXL1 gene variations are not associated with primary open-angle and primary angle-closure glaucomas.

  18224312   Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment

  18254956   DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity.

  18334928   Analysis of LOXL1 polymorphisms in a United States population with pseudoexfoliation glaucoma.

  18334947   Association of non-synonymous single nucleotide polymorphisms in the LOXL1 gene with pseudoexfoliation syndrome in India.

  18385063   Association of LOXL1 common sequence variants in German and Italian patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma.

  18385788   Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma.

  18421074   Lack of association between LOXL1 variants and primary open-angle glaucoma in three different populations.

  18450598   Association of LOXL1 gene polymorphisms with pseudoexfoliation in the Japanese.

  18483563   Lysyl oxidase-like protein 1 (LOXL1) gene polymorphisms and exfoliation glaucoma in a Central European population.

  18552979   LOXL1 genetic polymorphisms are associated with exfoliation glaucoma in the Japanese population.

  18618003   Exfoliation syndrome and exfoliation glaucoma-associated LOXL1 variations are not involved in pigment dispersion syndrome and pigmentary glaucoma.

  18636115   Lysyl oxidase-like 1 gene polymorphisms in Japanese patients with primary open angle glaucoma and exfoliation syndrome.

  18648524   Evaluation of LOXL1 polymorphisms in eyes with exfoliation glaucoma in Japanese.

  18958304   LOXL1 variants in elderly Japanese patients with exfoliation syndrome/glaucoma, primary open-angle glaucoma, normal tension glaucoma, and cataract.

  18974306   Genotype-correlated expression of lysyl oxidase-like 1 in ocular tissues of patients with pseudoexfoliation syndrome/glaucoma and normal patients.

  19098994   Evaluation of LOXL1 polymorphisms in primary open-angle glaucoma in southern and northern Chinese.

  19112534   Lack of association of polymorphisms in homocysteine metabolism genes with pseudoexfoliation syndrome and glaucoma

  19279689   TNF-alpha -308 G>A and -238 G>A polymorphisms are not major risk factors in Caucasian patients with exfoliation glaucoma

  19343041   Association of LOXL1 gene with Finnish exfoliation syndrome patients.

  19373106   Lysyl oxidase-like 1 gene polymorphisms in German patients with normal tension glaucoma, pigmentary glaucoma and exfoliation glaucoma.

  19503743   Association of LOXL1 polymorphisms with pseudoexfoliation in the Chinese.

  19779542   A genome-wide association analysis identified a novel susceptible locus for pathological myopia at 11q24.1.

  19936304   Evaluation of LOXL1 polymorphisms in exfoliation syndrome in a Chinese population.

  20051886   Lack of association of polymorphisms in elastin with pseudoexfoliation syndrome and glaucoma.

  20142848   Ethnicity-based subgroup meta-analysis of the association of LOXL1 polymorphisms with glaucoma.

  20431720   Major LOXL1 risk allele is reversed in exfoliation glaucoma in a black South African population.

  20808326   Genome-wide association study with DNA pooling identifies variants at CNTNAP2 associated with pseudoexfoliation syndrome.

  21067572   Association analysis of nine candidate gene polymorphisms in Indian patients with type 2 diabetic retinopathy.

  21139690   LOXL1 expression in lens capsule tissue specimens from individuals with pseudoexfoliation syndrome and glaucoma.

  21150032   Complex genetic mechanisms in glaucoma: an overview.

  21197115   Analysis of LOXL1 polymorphisms in a Saudi Arabian population with pseudoexfoliation glaucoma.

  21212179   LOXL1 promoter haplotypes are associated with exfoliation syndrome in a U.S. Caucasian population.

  21272281   Analysis of LOXL1 single nucleotide polymorphisms in Polish population with pseudoexfoliation syndrome.

  21320968   An investigation into LOXL1 variants in black South African individuals with exfoliation syndrome.

  21364909   Eurasian and Sub-Saharan African mitochondrial DNA haplogroup influences pseudoexfoliation glaucoma development in Saudi patients.

  21510775   Lack of association between LOXL1 gene polymorphisms and primary open angle glaucoma in the Saudi Arabian population.

  21572731   Genetics and genomics of pseudoexfoliation syndrome/glaucoma.

  21655354   Matrix metalloproteinase-9 genetic variation and primary angle closure glaucoma in a Caucasian population.

  21738402   Evaluation of LOXL1 polymorphisms in exfoliation syndrome in the Uygur population.

  21871452   Molecular genetics in glaucoma.

  21970694   Prevalence of high-risk alleles in the LOXL1 gene and its association with pseudoexfoliation syndrome and exfoliation glaucoma in a Latin American population.

  22128228   Association of lysyl oxidase-like 1 gene polymorphisms with exfoliation syndrome in Koreans.

  22194657   Analysis of LOXL1 gene variants in Japanese patients with branch retinal vein occlusion.

  22605916   Role of Lysyl oxidase-like 1 gene polymorphisms in Pakistani patients with pseudoexfoliative glaucoma.

  22690117   Evaluation of CNTNAP2 gene polymorphisms for exfoliation syndrome in Japanese.

  22765198   TT polymorphism in rs2165241 and rs1048661 region in lysyl oxidase like-1 gene may have a role in stress urinary incontinence physiopathology.

  23157966   Pseudoexfoliation syndrome, a systemic disorder with ocular manifestations.

  23378724   Association of LOXL1 gene polymorphisms with exfoliation syndrome/glaucoma and primary open angle glaucoma in a Turkish population.

  23441117   Evaluation of lysyl oxidase-like 1 gene polymorphisms in pseudoexfoliation syndrome in a Korean population.

  23687437   Development of novel LOXL1 genotyping method and evaluation of LOXL1, APOE and MTHFR polymorphisms in exfoliation syndrome/glaucoma in a Greek population.

  23869164   Association of lysyl oxidase-like 1 gene common sequence variants in Greek patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma.

  23960948   Review: The role of LOXL1 in exfoliation syndrome/glaucoma.

  24068861   The T allele of lysyl oxidase-like 1 rs41435250 is a novel risk factor for pseudoexfoliation syndrome and pseudoexfoliation glaucoma independently and through intragenic epistatic interaction.

  24265547   Association study of fibroblast growth factor 10 (FGF10) polymorphisms with susceptibility to extreme myopia in a Japanese population.

  24603551   Association between polymorphisms in lysyl oxidase-like 1 and susceptibility to pseudoexfoliation syndrome and pseudoexfoliation glaucoma.

  24739284   Common sequence variants in the LOXL1 gene in pigment dispersion syndrome and pigmentary glaucoma.

  24892565   Association of Lysyl Oxidase-Like 1 Gene Polymorphisms in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma in a Spanish Population.

  24917141   Association of LOXL1 polymorphisms with pseudoexfoliation, glaucoma, intraocular pressure, and systemic diseases in a Greek population. The Thessaloniki eye study.

  24938310   Novel common variants and susceptible haplotype for exfoliation glaucoma specific to Asian population.

  24967207   Lack of association between lysyl oxidase-like 1 polymorphisms and primary open angle glaucoma: a meta-analysis.

  25111588   Systematic review and metaanalysis of genetic association studies of urinary symptoms and prolapse in women.

  25130441   Lack of association of LOXL1 gene variants in Japanese patients with central retinal vein occlusion without clinically detectable pseudoexfoliation material deposits.

  25171643   Genetics of exfoliation syndrome and glaucoma.

  25185627   Mutation screen of LOXL1 in patients with female pelvic organ prolapse.

  25275910   Expression and regulation of LOXL1 and elastin-related genes in eyes with exfoliation syndrome.

  25304275   LOXL1 Gene Polymorphism With Exfoliation Syndrome/Exfoliation Glaucoma: A Meta-Analysis.

  25636109   [Association between LOXL1 gene polymorphisms and primary open angle glaucoma in Sichuan population].

  25706626   A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.

  25709925   The association of LOXL1 polymorphisms with exfoliation syndrome/glaucoma: Meta-analysis.

  25750511   Associations of polymorphisms of LOXL1 gene with primary open-angle glaucoma: a meta-analysis based on 5,293 subjects.

  26307087   Genetic variants and cellular stressors associated with exfoliation syndrome modulate promoter activity of a lncRNA within the LOXL1 locus.

  26319397   LOXL1 gene variants and their association with pseudoexfoliation glaucoma (XFG) in Spanish patients.

  26404116   Ethnicity-Based Differences in the Association of LOXL1 Polymorphisms with Pseudoexfoliation/Pseudoexfoliative Glaucoma: A Meta-Analysis.

  26690118   An Updated Review on the Genetics of Primary Open Angle Glaucoma.

  26758070   LOXL1 gene analysis in Turkish patients with exfoliation glaucoma.

  26855560   Lysyl oxidase-like 1 polymorphisms in a southwestern Greek cataract population with pseudoexfoliation syndrome.

  27116380   Correlation of Aqueous Humor Lysyl Oxidase Activity with TGF-ß Levels and LOXL1 Genotype in Pseudoexfoliation.

  27753755   Association of Lysyl Oxidase-Like 1 Gene Polymorphism in Turkish Patients With Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma.

  28505344   Genetics of glaucoma.

  28534485   Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1.

  28553957   Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.

  28721823   Genetic Risk Factors for Glaucoma and Exfoliation Syndrome Identified by Genome-wide Association Studies.

  29452408   Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma.

  29963644   LncRNAs in genetic basis of glaucoma.

  30011810   The Association between Epidermal Growth Factor Receptor (EGFR) Gene Polymorphisms and Lung Cancer Risk.

  30189755   Lack of association between lysyl oxidase-like 1 polymorphism in pseudoexfoliation syndrome and pseudoexfoliation glaucoma in North Indian population.

  30208148   Exfoliation syndrome associated with LOXL1 gene polymorphisms in a Black patient from Latin America: a case report.

  30364215   Association of LOXL1 gene common sequence variants in Jordanian patients with exfoliation syndrome and exfoliative glaucoma.

  30715578   Genetic association in female stress urinary incontinence based on proteomic findings: a case-control study.

  30986821   The protective variant rs7173049 at LOXL1 locus impacts on retinoic acid signaling pathway in pseudoexfoliation syndrome.

  31192002   Multiple Gene Polymorphisms Associated with Exfoliation Syndrome in the Uygur Population.

  31850260   Association of LOXL1 Gene Polymorphisms with Exfoliation Glaucoma Patients.

  32102031   Prevalence of Pseudoexfoliation Glaucoma Risk-associated Variants Within Lysyl Oxidase-like 1 in an Irish Population.

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