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SNP information rs1047781

RS1047781

Normal allele: AA

The weak secretory polymorphism rs1047781(385A>T) increases the risk of inflammatory bowel disease, colorectal cancer and oral cancer.

Polymorphism rs1047781 is related to topics like this:

Colorectal cancer genes

One of the prevalent cancer syndromes that can be inherited is colon cancer. Chromosome 2 contains...

Research and publications:

  7876234   Molecular cloning of a human genomic region containing the H blood group alpha(1,2)fucosyltransferase gene and two H locus-related DNA restriction fragments. Isolation of a candidate for the human Secretor blood group locus.

  8621666   Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals.

  22025780   FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection.

  22367966   Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.

  24941225   Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.

  26646561   Combinations of FUT2 gene polymorphisms and environmental factors are associated with oral cancer risk.

  26766790   Association of Ulcerative Colitis with FUT2 and FUT3 Polymorphisms in Patients from Southeast China.

  27350736   Comprehensive mutation screening for 10 genes in Chinese patients suffering very early onset inflammatory bowel disease.

  27802154   Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease.

  28453778   Examining the causal role of DNA methylation in the relationship between maternal vitamin B12 during pregnancy and child 8-year-old IQ, cognitive ability, and educational attainment: a two-stage Mendelian randomized trial

  28824326   FUT2 genetic variants as predictors of tumor development with hepatocellular carcinoma.

  30637338   Fucosylated Human Milk Oligosaccharides and N-Glycans in the Milk of Chinese Mothers Regulate the Gut Microbiome of Their Breast-Fed Infants during Different Lactation Stages.

  30790699   Phenotyping of Lewis and secretor HBGA from saliva and detection of new FUT2 gene SNPs from young children from the Amazon presenting acute gastroenteritis and respiratory infection.

  31260595   Association of FUT2 and ABO with Crohn's disease in Koreans.

  31661606   Association between cancer antigen 19-9 and diabetes risk: A prospective and Mendelian randomization study.

  32764781   Associations between fucosyltransferase 3 gene polymorphisms and ankylosing spondylitis: A case-control study of an east Chinese population.

  33835481   Detection of the weak-secretor rs1047781 (385A>T) single nucleotide polymorphism using an unlabeled probe high-resolution melting-based method.

  34336165   A Study on Fucosyltransferase 2 Gene Polymorphism and Secretion Status Related to Neonatal Necrotizing Enterocolitis.

  34589554   Association of Polymorphisms of Metabolism-Related Genes with Psoriasis Vulgaris in Han Chinese.

Gastrointestinal tract cancer

The occurrence of gastrointestinal (GI) tract cancers caused by genetic mutations is widespread...

Hereditary gastric cancer

Gastric cancer is the third leading cause of cancer-related deaths worldwide, with a 5-year...

Pancreas cancer genetic

Up to 15% of pancreatic cancers are attributed to gene mutations that are passed down through...

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