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Manganese

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Manganese, a trace mineral, is vital for various bodily functions, including brain and nervous system health, as well as enzyme activity. Although the body stores manganese in organs like the kidneys, liver, pancreas, and bones, it's crucial to supplement it through diet. This essential nutrient is abundant in seeds, whole grains, legumes, beans, nuts, leafy green vegetables, and tea. Below are ten scientifically-backed benefits of manganese. The discovery of a novel set of manganese transportopathies has significantly deepened our comprehension of manganese homeostasis regulation within the body. Through concerted efforts, the manganese efflux transporter SLC30A10 and the uptake transporter SLC39A14 collaboratively function to diminish manganese accumulation. Conversely, SLC39A8 serves an opposing role by facilitating manganese absorption. In cases of bi-allelic mutations affecting any of these transporter proteins, the equilibrium of manganese is disrupted, leading to neurological disorders: Hypermanganesaemia with dystonia 1 (due to SLC30A10 deficiency) and hypermanganesaemia with dystonia 2 (attributed to SLC39A14 deficiency) are characterized by manganese-induced neurotoxicity, while mutations in SLC39A8 result in a congenital disorder of glycosylation type II due to manganese deficiency.

Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Manganese and see a list of existing studies.

SNP polymorphisms related to the topic Manganese:

rs1568569
rs17060812
rs896378
rs7833266
rs4872479
rs13103835
rs2165265
rs151402
rs4588460
rs13126885
rs151392
rs7664683
rs4699012
rs2298752
rs151401
rs7699390
rs6700061
rs4846607
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