Manganese

By Li Dali, Ph.D.

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Manganese, a trace mineral, is vital for various bodily functions, including brain and nervous system health, as well as enzyme activity. Although the body stores manganese in organs like the kidneys, liver, pancreas, and bones, it's crucial to supplement it through diet. This essential nutrient is abundant in seeds, whole grains, legumes, beans, nuts, leafy green vegetables, and tea. Below are ten scientifically-backed benefits of manganese. The discovery of a novel set of manganese transportopathies has significantly deepened our comprehension of manganese homeostasis regulation within the body. Through concerted efforts, the manganese efflux transporter SLC30A10 and the uptake transporter SLC39A14 collaboratively function to diminish manganese accumulation. Conversely, SLC39A8 serves an opposing role by facilitating manganese absorption. In cases of bi-allelic mutations affecting any of these transporter proteins, the equilibrium of manganese is disrupted, leading to neurological disorders: Hypermanganesaemia with dystonia 1 (due to SLC30A10 deficiency) and hypermanganesaemia with dystonia 2 (attributed to SLC39A14 deficiency) are characterized by manganese-induced neurotoxicity, while mutations in SLC39A8 result in a congenital disorder of glycosylation type II due to manganese deficiency.

Follow the link of the selected polymorphism to read a brief description of how the selected polymorphism affects Manganese and see a list of existing studies.

SNP polymorphisms related to the topic Manganese:

About The Author

Li Dali, a National Foundation for Outstanding Youth Fund recipient, is a researcher at the School of Life Sciences in East China Normal University. He earned his PhD in genetics from Hunan Normal University in 2007 and conducted collaborative research at Texas A&M University during his doctoral studies. Li Dali and his team have optimized and innovated gene editing technology, leading to the establishment of a world-class system for constructing gene editing disease models.

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