SNP information rs7582694

Research and publications:

  18579578   A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.

  19092842   Additive effects of major IRF5 and STAT4 risk alleles in primary Sjögren's syndrome.

  19333953   High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups.

  19717398   Variation in STAT4 is associated with systemic lupus erythematosus in a Finnish family cohort.

  20237121   Genetic variants of STAT4 associated with rheumatoid arthritis in persons of Asian and European ancestry do not replicate in African Americans.

  20454450   Evidence that STAT4 is a common autoimmune gene: rs7574865 is associated with Crohn's disease of the colon and early onset of the disease.

  20535138   STAT4 is a confirmed genetic risk factor for Sjögren's syndrome and may be involved in type 1 interferon signaling.

  21167895   Association of genetic variations in the STAT4 and IRF7/KIAA1542 regions with systemic lupus erythematosus in a Northern Han Chinese population.

  21179067   A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE.

  21258797   A single-nucleotide polymorphism of the STAT4 gene is associated with systemic lupus erythematosus (SLE) in female Chinese population.

  21635716   Aspects of innate immunity in Sjögren's syndrome.

  22162633   Activation of type I interferon pathway in systemic lupus erythematosus: association with distinct clinical phenotypes.

  22479607   Analysis of IL12B gene variants in inflammatory bowel disease.

  22536486   Lupus nephritis: an overview of recent findings.

  22640752   The genetics of lupus: a functional perspective.

  22654485   Role of cytokines in systemic lupus erythematosus: recent progress from GWAS and sequencing.

  22729903   Contribution of STAT4 gene single-nucleotide polymorphism to systemic lupus erythematosus in the Polish population.

  22753952   Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways.

  22870458   Modern aspects of the pathogenesis of Sjögren's syndrome.

  23227085   Genetics of SLE: functional relevance for monocytes/macrophages in disease.

  24386384   Association of STAT4 polymorphism with severe renal insufficiency in lupus nephritis.

  25034154   Clinical perspectives on lupus genetics: advances and opportunities.

  25829184   STAT4 genetic polymorphisms association with spontaneous clearance of hepatitis B virus infection.

  26798662   Genetic Factors in Systemic Lupus Erythematosus: Contribution to Disease Phenotype.

  26880555   Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity.

  27235632   STAT4 single nucleotide gene polymorphisms and susceptibility to endometriosis-related infertility.

  27693588   Genetics of human lupus nephritis.

  28977835   Association of STAT4 and PTPN22 polymorphisms and their interactions with type-1 autoimmune hepatitis susceptibility in Chinese Han children.

  30770922   Genetics and epigenetics of primary Sjögren's syndrome.

  30887509   Influence of STAT4 gene polymorphisms in the pathogenesis of endometriosis.

  31475028   Host Genetic Determinants of Hepatitis B Virus Infection.

  32771030   Meta-analysis of genome-wide association study identifies FBN2 as a novel locus associated with systemic lupus erythematosus in Thai population.

  33687153   Association of the STAT4, CDKN1A, and IRF5 variants with risk of lupus nephritis and renal biopsy classification in patients in Vietnam.