SNP information rs6983267

Research and publications:

  17401363   Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.

  17529967   Genome-wide association study identifies novel breast cancer susceptibility loci.

  17618282   A common genetic risk factor for colorectal and prostate cancer.

  17618284   A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21.

  17713544   Lack of a relationship between the common 8q24 variant rs6983267 and risk of chronic lymphocytic leukemia.

  17903305   NHLBI's Framingham Heart Study genome-wide association study of breast and prostate cancer.

  17925536   Association between two unlinked loci at 8q24 and prostate cancer risk among European Americans.

  17978284   Confirmation study of prostate cancer risk variants at 8q24 in African Americans identifies a novel risk locus.

  18056436   Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry.

  18172290   Allelic imbalance at rs6983267 suggests selection of the risk allele in somatic colorectal tumor evolution.

  18224312   Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment

  18231127   8q24 and prostate cancer: association with advanced disease and meta-analysis.

  18268117   A common 8q24 variant and the risk of colon cancer: a population-based case-control study.

  18274536   Genome-wide association studies: progress and potential for drug discovery and development.

  18349290   Association of genetic variants at 8q24 with breast cancer risk.

  18360876   Chromosome 8q24 markers: risk of early-onset and familial prostate cancer.

  18362937   CASP8 variants D302H and -652 6N ins/del do not influence the risk of colorectal cancer in the United Kingdom population.

  18372901   Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

  18491292   Cumulative effect of five genetic variants on prostate cancer risk in multiple study populations.

  18535017   Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk.

  18577746   Multiple loci with different cancer specificities within the 8q24 gene desert.

  18670647   Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.

  18682823   Canadian Urological Association, 63rd Annual Meeting, Edmonton, AB, June 22-25, 2008.

  18704501   Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers.

  18726982   Association of genetic polymorphisms at 8q24 with the risk of prostate cancer in a Japanese population.

  18765558   Effect of genetic variability within 8q24 on aggressiveness patterns at diagnosis and familial status of prostate cancer.

  18768484   Family-based samples can play an important role in genetic association studies.

  18768513   Common 8q24 sequence variations are associated with Asian Indian advanced prostate cancer risk.

  18794092   Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.

  18839428   Investigation of the colorectal cancer susceptibility region on chromosome 8q24.21 in a large German case-control sample.

  18949397   The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1.

  18973230   Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.

  18974127   Association study of prostate cancer susceptibility variants with risks of invasive ovarian, breast, and colorectal cancer.

  18990762   Associations between variants of the 8q24 chromosome and nine smoking-related cancer sites.

  19011631   Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.

  19047180   A range of cancers is associated with the rs6983267 marker on chromosome 8.

  19058137   Clinical utility of five genetic variants for predicting prostate cancer risk and mortality.

  19104501   Prostate cancer genomics: towards a new understanding.

  19116992   Association of reported prostate cancer risk alleles with PSA levels among men without a diagnosis of prostate cancer.

  19155440   Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21.

  19188186   Genetic variants and family history predict prostate cancer similar to prostate-specific antigen.

  19304784   Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.

  19357349   Association of common genetic variants in SMAD7 and risk of colon cancer.

  19366828   Evaluation of 8q24 and 17q risk loci and prostate cancer mortality.

  19366831   Analysis of recently identified prostate cancer susceptibility loci in a population-based study: associations with family history and clinical features.

  19373277   Validating, augmenting and refining genome-wide association signals

  19395656   The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression.

  19434427   Analytical methods for inferring functional effects of single base pair substitutions in human cancers.

  19434657   Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.

  19474294   Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

  19520795   Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European Americans.

  19528667   Association of chromosome 8q variants with prostate cancer risk in Caucasian and Hispanic men.

  19549807   Prostate cancer risk associated loci in African Americans.

  19549893   Evaluation of the 8q24 prostate cancer risk locus and MYC expression.

  19561604   The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.

  19561607   The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.

  19562729   Common variants in 8q24 are associated with risk for prostate cancer and tumor aggressiveness in men of European ancestry.

  19567509   Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes

  19602258   Significance of common variants on human chromosome 8q24 in relation to the risk of prostate cancer in native Japanese men.

  19648920   Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer.

  19680443   Functional enhancers at the gene-poor 8q24 cancer-linked locus.

  19690179   Functional and clinical significance of variants localized to 8q24 in colon cancer.

  19767754   Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.

  19767755   Identification of a new prostate cancer susceptibility locus on chromosome 8q24.

  19786869   Recent insights into the pathogenesis of colorectal cancer.

  19822575   Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing

  19843678   Enrichment of low penetrance susceptibility loci in a Dutch familial colorectal cancer cohort.

  19847790   Allelic imbalance (AI) identifies novel tissue-specific cis-regulatory variation for human UGT2B15.

  19857256   Association between an 8q24 locus and the risk of colorectal cancer in Japanese.

  19866473   Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men.

  19895682   No effect of cancer-associated SNP rs6983267 in the 8q24 region on co-expression of MYC and TCF7L2 in normal colon tissue.

  19906782   Genome-wide association studies in cancer--current and future directions.

  19916168   Genome-wide association studies--a summary for the clinical gastroenterologist.

  20039378   Estimation of genotype relative risks from pedigree data by retrospective likelihoods.

  20065031   Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells.

  20133699   Long-range enhancers on 8q24 regulate c-Myc.

  20158306   Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer.

  20407467   Genome-wide linkage analyses of hereditary prostate cancer families with colon cancer provide further evidence for a susceptibility locus on 15q11-q14.

  20419766   Epidemiologic and genetic aspects of spina bifida and other neural tube defects.

  20450899   Individual and cumulative association of prostate cancer susceptibility variants with clinicopathologic characteristics of the disease.

  20460480   Susceptibility loci associated with prostate cancer progression and mortality.

  20482849   NOTCH2 in breast cancer: association of SNP rs11249433 with gene expression in ER-positive breast tumors without TP53 mutations.

  20501757   Low-penetrance susceptibility variants in familial colorectal cancer.

  20505153   A compendium of genome-wide associations for cancer: critical synopsis and reappraisal.

  20530236   Genetic variation at chromosome 8q24 in osteosarcoma cases and controls.

  20530476   Risk of genome-wide association study-identified genetic variants for colorectal cancer in a Chinese population.

  20551303   Association between genetic variants in the 8q24 cancer risk regions and circulating levels of androgens and sex hormone-binding globulin.

  20560206   Insights into colon cancer etiology via a regularized approach to gene set analysis of GWAS data.

  20564319   Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation.

  20584312   8q24 sequence variants in relation to prostate cancer risk among men of African descent: a case-control study.

  20585100   Genome-wide association studies of cancer.

  20590552   The number of prostate cancer risk alleles may reveal a possibly “minor” disease.

  20620408   Genetic prostate cancer risk assessment: common variants in 9 genomic regions are associated with cumulative risk.

  20627891   An 8q24 gene desert variant associated with prostate cancer risk confers differential in vivo activity to a MYC enhancer.

  20628028   Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosis.

  20628624   Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".

  20634801   8q24 allelic imbalance and MYC gene copy number in primary prostate cancer.

  20638935   Susceptibility genetic variants associated with colorectal cancer risk correlate with cancer phenotype.

  20648012   Association studies on 11 published colorectal cancer risk loci.

  20659471   Genetic heterogeneity in colorectal cancer associations between African and European americans.