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SNP information rs5522

Normal allele: TT

Alteration of the functional mineralocorticoid receptor (MR) gene affects the cortisol awakening response after dexamethasone.

Polymorphism rs5522 is related to topics like this:

21 hydroxylase

The CYP21A2 gene encodes the human protein, Steroid 21-hydroxylase. This enzyme hydroxylates...


Research and publications:

  16642433   Polymorphism in maternal LRP8 gene is associated with fetal growth

  18227835   Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking

  18468809   Glucocorticoid sensitivity in fibromyalgia patients: decreased expression of corticosteroid receptors and glucocorticoid-induced leucine zipper.

  19325532   Association of a mineralocorticoid receptor gene polymorphism with hypertension in a Spanish population.

  19359258   Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.

  19665310   Functional mineralocorticoid receptor (MR) gene variation influences the cortisol awakening response after dexamethasone.

  20528958   The impact of mineralocorticoid receptor ISO/VAL genotype (rs5522) and stress on reward learning.

  20680430   No associations between single nucleotide polymorphisms in corticoid receptor genes and heart rate and cortisol responses to a standardized social stress test in adolescents: the TRAILS study.

  21095064   Human mineralocorticoid receptor (MR) gene haplotypes modulate MR expression and transactivation: implication for the stress response.

  21112363   Association of FKBP5 gene haplotypes with completed suicide in the Japanese population.

  21917807   Corticotropin-releasing hormone receptor type 1 (CRHR1) genetic variation and stress interact to influence reward learning.

  22584804   The role of a mineralocorticoid receptor gene functional polymorphism in the symptom dimensions of persistent ADHD.

  22719919   Glutamate and synaptic plasticity systems and smoking behavior: results from a genetic association study.

  23055001   Genetic evidence for the association of the hypothalamic-pituitary-adrenal (HPA) axis with ADHD and methylphenidate treatment response.

  23543128   MR and GR functional SNPs may modulate tobacco smoking susceptibility.

  24059494   Effect of NR3C2 genetic polymorphisms on the blood pressure response to enalapril treatment.

  24166410   HPA axis genetic variation, cortisol and psychosis in major depression.

  24497894   A Conceptual Model of Psychoneurological Symptom Cluster Variation in Women with Breast Cancer: Bringing Nursing Research to Personalized Medicine.

  24596569   Gene-environment interactions and intermediate phenotypes: early trauma and depression.

  24691024   Investigation of genetic variants, birthweight and hypothalamic-pituitary-adrenal axis function suggests a genetic variant in the SERPINA6 gene is associated with corticosteroid binding globulin in the western Australia pregnancy cohort (Raine)

  25220664   A common mineralocorticoid receptor polymorphism (I180V) interacts with life events in relation to perfectionism in eating disorders: a pilot study.

  25583614   HPA axis genetic variation, pubertal status, and sex interact to predict amygdala and hippocampus responses to negative emotional faces in school-age children.

  25686805   Mineralocorticoid receptor haplotypes sex-dependently moderate depression susceptibility following childhood maltreatment.

  25741868   Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

  26049084   Association of Mineralocorticoid Receptor Polymorphism I180V With Left Ventricular Hypertrophy in Resistant Hypertension.

  26189450   Genetic Moderation of Stress Effects on Corticolimbic Circuitry.

  26228405   Corticosteroid receptor genes and childhood neglect influence susceptibility to crack/cocaine addiction and response to detoxification treatment.

  26260058   Two novel genetic variants in the mineralocorticoid receptor gene associated with spontaneous preterm birth.

  26595470   Amygdala functional connectivity, HPA axis genetic variation, and life stress in children and relations to anxiety and emotion regulation.

  26882083   Associations between Single-Nucleotide Polymorphisms in Corticotropin-Releasing Hormone-Related Genes and Irritable Bowel Syndrome.

  26970338   Stress and Depression: a Crucial Role of the Mineralocorticoid Receptor.

  27528460   HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition.

  27936434   Mineralocorticoid receptor haplotype, estradiol, progesterone and emotional information processing.

  28334414   Association of a Haplotype in the NR3C2 Gene, Encoding the Mineralocorticoid Receptor, With Chronic Central Serous Chorioretinopathy.

  28364727   Hypothalamic-pituitary-adrenal axis genetic variation and early stress moderates amygdala function.

  28686058   Genetic Associations and Interactions Between the NR3C1 (GR) and NR3C2 (MR) Genes and Aggressive Behavior in a Central South Chinese Han Population.

  29147678   A Haplotype Associated with Enhanced Mineralocorticoid Receptor Expression Facilitates the Stress-Induced Shift from "Cognitive" to "Habit" Learning.

  29576985   Influence of allelic variations in relation to norepinephrine and mineralocorticoid receptors on psychopathic traits: a pilot study.

  30292562   NR3C2 Gene is Associated with Susceptibility to High-Altitude Pulmonary Edema in Han Chinese.

  30292651   Genetic variation of the mineralocorticoid receptor gene (MR, NR3C2) is associated with a conceptual endophenotype of "CRF-hypoactivity".

  30619769   Prognostic Impact of Genetic Polymorphism in Mineralocorticoid Receptor and Comorbidity With Hypertension in Androgen-Deprivation Therapy.

  31852079   NR3C2 gene polymorphism is associated with risk of gestational hypertension in Han Chinese women.

  32558353   Functional polymorphisms of the mineralocorticoid receptor gene NR3C2 are associated with diminished memory decline: Results from a longitudinal general-population study.

  32757697   Further evidence for the association of GAL, GALR1¬†and NPY1R¬†variants with opioid dependence.

  34569641   NR3C2 genotype is associated with response to spironolactone in diastolic heart failure patients from the Aldo-DHF trial.

  35740293   Genetic Profiling of Glucocorticoid (NR3C1) and Mineralocorticoid (NR3C2) Receptor Polymorphisms before Starting Therapy with Androgen Receptor Inhibitors: A Study of a Patient Who Developed Toxic Myocarditis after Enzalutamide Treatment.

Serotonin transporter sert

In humans, the SLC6A4 gene encodes a protein referred to as both the sodium-dependent serotonin...

A psychosis known as schizophrenia impacts an individual's thinking, sense of self, and...

The membrane-bound protein called the dopamine transporter (DAT), also known as the...

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