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SNP information rs4994

Normal allele: AA

A beta-3-adrenergic receptor mutation is associated with visceral obesity but lowers serum triglyceride levels. Carriers of the G allele necessarily need strength training to lose weight and keep the body in good shape.

Polymorphism rs4994 is related to topics like this:

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Incorporating protein into your diet can aid in weight loss, and maintaining a high protein diet...

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Research and publications:

  7609750   Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene.

  7609752   Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity.

  8903328   The Trp64Arg mutation of the beta3 adrenergic receptor gene has no effect on obesity phenotypes in the Québec Family Study and Swedish Obese Subjects cohorts.

  8954053   Role of the beta 3-adrenergic receptor locus in obesity and noninsulin-dependent diabetes among members of Caucasian families with a diabetic sibling pair.

  9054940   A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2.

  9100608   Lack of association between the Trp64 Arg mutation in the beta 3-adrenergic receptor gene and obesity in Japanese men: a longitudinal analysis.

  9112025   A mutation of the beta 3-adrenergic receptor is associated with visceral obesity but decreased serum triglyceride.

  9449691   A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans.

  9709965   The Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is not associated with obesity or type 2 diabetes mellitus in a large population-based Caucasian cohort.

  9814483   Trp64Arg variant of the beta3-adrenoceptor and insulin resistance in obese postmenopausal women.

  9892244   Polymorphism of the human beta3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function.

  10323390   The association between Trp64Arg polymorphism of the beta3-adrenergic receptor and autonomic nervous system activity.

  10323402   Trp64Arg polymorphism of the beta3-adrenergic receptor gene in pregnancy: association with mild gestational diabetes mellitus.

  10999801   Studies of the synergistic effect of the Trp/Arg64 polymorphism of the beta3-adrenergic receptor gene and the -3826 A-->G variant of the uncoupling protein-1 gene on features of obesity and insulin resistance in a population-based sample of 379

  11095426   Insulin response to glucose is lower in individuals homozygous for the Arg 64 variant of the beta-3-adrenergic receptor.

  15472194   Effects of the Trp64Arg polymorphism in the beta3-adrenergic receptor gene on insulin sensitivity in small for gestational age neonates.

  17512307   Association analyses of adrenergic receptor polymorphisms with obesity and metabolic alterations.

  17825092   Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography

  18304332   No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins

  18426866   Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort

  18513389   New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background

  18603647   Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response

  18611262   Genetic variation in candidate obesity genes ADRB2, ADRB3, GHRL, HSD11B1, IRS1, IRS2, and SHC1 and risk for breast cancer in the Cancer Prevention Study II.

  18936436   Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994

  19131662   A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients

  19263529   Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach

  19553224   Trp64Arg polymorphism in ADRB3 gene is associated with elite endurance performance.

  19565482   Association of adrenergic receptor gene polymorphisms with different fibromyalgia syndrome domains.

  19587357   A systematic meta-analysis of genetic association studies for diabetic retinopathy

  19736300   Genetic basis of inter-individual variability in the effects of exercise on the alleviation of lifestyle-related diseases

  19876010   A preliminary candidate genotype-intermediate phenotype study of satiation and gastric motor function in obesity

  20028936   Are elite endurance athletes genetically predisposed to lower disease risk?

  20078877   Gene polymorphisms in association with emerging cardiovascular risk markers in adult women

  20503258   Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City.

  20981351   Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study.

  21285172   Positive correlation between Beta-3-Adrenergic Receptor (ADRB3) gene and gout in a Chinese male population.

  21467728   Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.

  21894447   Are centenarians genetically predisposed to lower disease risk?

  22355322   Gene-gene and gene-environmental interactions of childhood asthma: a multifactor dimension reduction approach.

  22391941   Meta-analysis of association studies between five candidate genes and type 2 diabetes in Chinese Han population.

  22775001   Polymorphisms in Fas gene is associated with HIV-related lipoatrophy in Thai patients.

  22858200   Angiotensinogen gene polymorphisms and food-intake behavior in young, normal female subjects in Japan.

  22938532   Sequencing and analysis of a South Asian-Indian personal genome.

  24138564   The presence of at least three alleles of the ADRB3 Trp64Arg (C/T) and UCP1 -3826A/G polymorphisms is associated with protection to overweight/obesity and with higher high-density lipoprotein cholesterol levels in Caucasian-Brazilian patients wi

  24201118   Significant role of ADRB3 rs4994 towards the development of coronary artery disease.

  24460850   The interaction between beta-3 adrenergic receptor polymorphism and obesity to periodontal disease in community-dwelling elderly Japanese.

  24491308   Systematic review and meta-analysis of candidate gene association studies of lower urinary tract symptoms in men.

  24944790   Screening for 392 polymorphisms in 141 pharmacogenes.

  25111588   Systematic review and metaanalysis of genetic association studies of urinary symptoms and prolapse in women.

  25112403   Lysyl oxidase rs1800449 polymorphism and cancer risk among Asians: evidence from a meta-analysis and a case-control study of colorectal cancer.

  25368670   CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits.

  25516658   Case-control study of diabetes-related genetic variants and pancreatic cancer risk in Japan.

  26365620   Genetic association of APOA5 and APOE with metabolic syndrome and their interaction with health-related behavior in Korean men.

  26373931   Polymorphism profiling of nine high altitude relevant candidate gene loci in acclimatized sojourners and adapted natives.

  26410617   Association analysis of the beta-3 adrenergic receptor Trp64Arg (rs4994) polymorphism with urate and gout.

  26410938   [Genetic Association of ADRA2A and ADRB3 Genes with Metabolic Syndrome among the Tatars].

  26602921   A Multiple Interaction Analysis Reveals ADRB3 as a Potential Candidate for Gallbladder Cancer Predisposition via a Complex Interaction with Other Candidate Gene Variations.

  27217270   Pharmacogenetic Associations of Antipsychotic Drug-Related Weight Gain: A Systematic Review and Meta-analysis.

  27246401   Genetic Background, Adipocytokines, and Metabolic Disorders in Postmenopausal Overweight and Obese Women.

  27601774   Genetic variants influencing effectiveness of exercise training programmes in obesity - an overview of human studies.

  27798356   Lack of replication of associations between multiple genetic polymorphisms and endurance athlete status in Japanese population.

  27806373   The Genetic Predisposition Score of Seven Obesity-Related Single Nucleotide Polymorphisms Is Associated with Better Metabolic Outcomes after Roux-en-Y Gastric Bypass.

  28521197   Association of β3-adrenergic receptor rs4994 polymorphisms with the risk of type 2 diabetes: A systematic review and meta-analysis.

  28652652   Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update.

  28738793   Association between 28 single nucleotide polymorphisms and type 2 diabetes mellitus in the Kazakh population: a case-control study.

  29381017   [The investigation the combined effect of SNP rs9939609 (gene FTO) and rs4994 (gene ADRB3) polymorphisms on risk of obesity].

  29587766   ADRB3 polymorphism rs4994 (Trp64Arg) associates significantly with bodyweight elevation and dyslipidaemias in Saudis but not rs1801253 (Arg389Gly) polymorphism in ARDB1.

  29755414   Non-Synonymous Single-Nucleotide Polymorphisms and Physical Activity Interactions on Adiposity Parameters in Malaysian Adolescents.

  30123371   Multiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to Gout.

  30584432   Genetic Identification for Non-Communicable Disease: Findings from 20 Years of the Tehran Lipid and Glucose Study.

  30607769   Pharmacogenetic Correlates of Antipsychotic-Induced Weight Gain in the Chinese Population.

  30645902   [The study of energy balance in individuals with the Trp64Arg polymorphism of the β3-adrenoreceptor gene].


  31670283   Adrenergic receptor beta-3 rs4994 (T>C) and liver X receptor alpha rs12221497 (G>A) polymorphism in Pakistanis with metabolic syndrome.

  31929840   Beta-3-adrenergic Receptor rs4994 Polymorphism Is a Potential Biomarker for the Development of Nonalcoholic Fatty Liver Disease in Overweight/Obese Individuals.

  32213001   UEG Week 2019 Poster Presentations.

  32340905   Can study of the ADRB3 gene help improve weight loss programs in obese individuals?

  32452228   The relationship between PNP, GSTO-1, AS3MT and ADRB3 gene polymorphisms and urinary arsenic concentration among copper smelter and refinery employers.

  33170161   Genetic test for the prescription of diets in support of physical activity.

  33458655   Comparison of Beta-2 Adrenergic Receptor Gene Polymorphisms Between Patients with Fibromyalgia Syndrome and Healthy Controls.

  33763108   Whole Genome Interpretation for a Family of Five.

  34131278   Genetic polymorphisms associated with obesity in the Arab world: a systematic review.

  34420811   Association of FTO, ABCA1, ADRB3, and PPARG variants with obesity, type 2 diabetes, and metabolic syndrome in a Northwest Mexican adult population.

  34539437   Effects of Four Lipid Metabolism-Related Polymorphisms on Body Composition Improvements After 12 Weeks of High-Intensity Interval Training and Dietary Energy Restriction in Overweight/Obese Adult Women: A Pilot Study.

  34638656   Towards Understanding the Genetic Nature of Vasovagal Syncope.

  34691150   Prediction and Identification of Power Performance Using Polygenic Models of Three Single-Nucleotide Polymorphisms in Chinese Elite Athletes.

  35199539   Adrenergic receptors gene polymorphisms and autonomic nervous control of heart and vascular tone.

  35308505   Vitamin D Supplementation and Genetic Polymorphisms Impact on Weight Loss Diet Outcomes in Caucasians: A Randomized Double-Blind Placebo-Controlled Clinical Study.

  35560161   Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon.

  35947209   Development of a genetic risk score for obesity predisposition evaluation.

  36089400   Differential Effect of Fat Intake on Blood Pressure in Healthy Japanese Women with and without the Variant of Fat Mass and Obesity-Associated Gene.

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