SNP information rs4958847

Research and publications:

  18438406   Genetic determinants of ulcerative colitis include the ECM1 locus and five loci involved in Crohn's disease.

  18580884   Confirmation of the association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort.

  18853133   Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.

  19098858   IRGM gene polymorphisms may predispose to fistula formation in Crohn's disease.

  19140132   Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.

  19165925   Deletion polymorphisms upstream of IRGM are associated with altered IRGM expression and Crohn's disease.

  19174780   Confirmation of multiple susceptibility loci for Crohn's disease in a large Dutch-Belgian cohort.

  19491842   Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach.

  19683022   Lack of association of NKX2-3, IRGM, and ATG16L1 inflammatory bowel disease susceptibility variants with celiac disease.

  19953089   Differences in genetic background between active smokers, passive smokers, and nonsmokers with Crohn's disease.

  20106866   Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease.

  20177049   Insufficient evidence for association of NOD2/CARD15 or other inflammatory bowel disease-associated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantation.

  20395867   Do Crohn's disease-associated autophagy genes ATG16L1 and IRGM play a role in granuloma formation?

  20857526   High prevalence of viable Mycobacterium avium subspecies paratuberculosis in Crohn's disease.

  20886065   Molecular reclassification of Crohn's disease by cluster analysis of genetic variants.

  21049557   NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients.

  21333900   The role of genetics in IBS

  21487504   Immunopathogenesis of inflammatory bowel disease.

  21734790   NOD2 and ATG16L1 polymorphisms influence monocyte response in Crohn's disease.

  21936032   Digesting the genetics of inflammatory bowel disease: insights from studies of autophagy risk genes.

  21978003   Autophagy modulates the Mycobacterium tuberculosis-induced cytokine response.

  22065112   JAK2 rs10758669 variant in Crohn's disease: alteration of the intestinal barrier as one of the mechanisms of action.

  22228152   Mutations in IRGM are associated with an increased need for surgery in patients with ileocolonic Crohn's disease.

  22508677   Associations between genetic variants in the IRGM gene and inflammatory bowel diseases in the Korean population.

  22713085   IRGM gene polymorphisms and risk of gastric cancer.

  22879892   Polymorphisms in autophagy genes and susceptibility to tuberculosis.

  22984424   Both baseline clinical factors and genetic polymorphisms influence the development of severe functional status in ankylosing spondylitis.

  23300620   Genotype/phenotype analysis of 53 genetic polymorphisms associated with Crohn's disease.

  23365659   IRGM variants and susceptibility to inflammatory bowel disease in the German population.

  24739953   Role of genetic variants of autophagy genes in susceptibility for non-medullary thyroid cancer and patients outcome.

  25191865   Association of IRGM gene mutations with inflammatory bowel disease in the Indian population.

  25369137   A multilocus genetic study in a cohort of Italian SLE patients confirms the association with STAT4 gene and describes a new association with HCP5 gene.

  25664588   Autophagy in Helicobacter pylori Infection and Related Gastric Cancer.

  25944217   Genetic Polymorphisms in Autophagy-Associated Genes in Korean Children With Early-Onset Crohn Disease.

  26066377   Autophagy and inflammatory bowel disease: association between variants in the autophagy-related gene IRGM and susceptibility to Crohn's disease.

  26993061   Accounting for selection and correlation in the analysis of two-stage genome-wide association studies.

  28983640   A haplotypic variant at the IRGM locus and rs11747270 are related to the susceptibility for chronic periodontitis.

  29788077   IRGM gene variants alter the relationship between visceral adipose tissue and NAFLD in patients with Crohn's disease.

  29960072   Among autophagy genes, ATG16L1, but not IRGM, is associated with Crohn's disease in Iranians.

  29992164   Polymorphisms in Autophagy-Related Gene IRGM Are Associated with Susceptibility to Autoimmune Thyroid Diseases.

  31654602   Genetic polymorphisms of the ATG16L1 and IRGM genes in Malaysian patients with Crohn's disease.

  31714311   Clinical and genetic factors influence the time to surgical recurrence after ileocolectomy for Crohn's disease.

  32045400   Clinical and genetic factors associated with complications after Crohn's ileocolectomy.

  33147747   Pathogenic Single Nucleotide Polymorphisms on Autophagy-Related Genes.

  34407136   Differential prevalence of pathobionts and host gene polymorphisms in chronic inflammatory bowel diseases: Crohn's disease and intestinal tuberculosis.

  34961976   Analysis of rs1864182 and rs1864183 variants in ATG10 gene and antineutrophil cytoplasmic autoantibody-associated vasculitis in Chinese Guangxi population.

  35699756   Immunity-related GTPase IRGM at the intersection of autophagy, inflammation, and tumorigenesis.