SNP information rs3197999

Research and publications:

  18438406   Genetic determinants of ulcerative colitis include the ECM1 locus and five loci involved in Crohn's disease.

  18587394   Genome-wide association identifies more than 30 different susceptibility loci for Crohn's disease.

  19079170   Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis.

  19474294   Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

  19944697   Genome-wide association analysis in primary sclerosing cholangitis.

  20018022   Replication of recently identified associated single-nucleotide polymorphisms from six autoimmune diseases in Genetic Analysis Workshop 16 rheumatoid arthritis data.

  20024904   Variants at the 3p21 locus influence susceptibility and phenotype both in adults and early-onset patients with inflammatory bowel disease.

  20228799   Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

  20369022   Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.

  20570966   Nonsecretory fucosyltransferase 2 (FUT2) status is associated with Crohn's disease.

  20662065   Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus.

  20805105   Synthetic associations in the context of genome-wide association scan signals

  21102463   Genome-wide meta-analysis increases the number of confirmed susceptibility loci for Crohn's disease to 71.

  21151127   Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.

  21297633   Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

  21304977   An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.

  21425313   Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9.

  21730793   The influence of risk alleles for Crohn's disease and smoking on the location of the disease.

  21752155   Genetic susceptibility to inflammation and colonic transit in lower functional gastrointestinal disorders: preliminary analysis.

  21830272   Different and overlapping genetic loci in Crohn's disease and ulcerative colitis: correlation with pathogenesis.

  22087277   Protein characterization of a possible mechanism SNP for Crohn's disease: macrophage-stimulating protein R689C replacement.

  22237417   Macrophage-stimulating protein polymorphism rs3197999 is associated with a gain of function: implications for inflammatory bowel disease.

  22551073   LDGIdb: a database of gene interactions inferred from long-range strong linkage disequilibrium between pairs of SNPs.

  22554193   Fine mapping and replication of genetic risk loci in primary sclerosing cholangitis.

  22606245   Evolutionary dynamics of co-segregating gene clusters associated with complex diseases.

  23000205   Gene network analysis of small molecules with autoimmune disease associated genes predicts a novel strategy for drug efficacy.

  23028907   Limited evidence for parent-of-origin effects in inflammatory bowel disease associated loci.

  23300620   Genotype/phenotype analysis of 53 genetic polymorphisms associated with Crohn's disease.

  23422030   Macrophage stimulating protein variation enhances the risk of sporadic extrahepatic cholangiocarcinoma.

  26355565   Inflammatory bowel disease (IBD) locus 12: is glutathione peroxidase-1 (GPX1) the relevant gene?

  26490195   Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study.

  27156530   Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility.

  27506385   Predicting gene targets from integrative analyses of summary data from GWAS and eQTL studies for 28 human complex traits.

  28129359   High-Throughput Characterization of Blood Serum Proteomics of IBD Patients with Respect to Aging and Genetic Factors.