SNP information rs2304256

Research and publications:

  15657875   Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.

  18270328   Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.

  19440814   Lack of association between tyrosine kinase 2 (TYK2) gene polymorphisms and susceptibility to SLE in a Japanese population.

  19442287   Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study.

  19567624   Evidence for genetic association and interaction between the TYK2 and IRF5 genes in systemic lupus erythematosus.

  19604093   Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients

  19653082   Compelling evidence for combined polymorphisms of the tyrosine kinase 2 gene and signal transducer and transcription activator 3 gene as a DNA-based biomarker of susceptibility to Crohn's disease in a Japanese population.

  19714582   Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors.

  19758313   Tyrosine kinase 2 and interferon regulatory factor 5 polymorphisms are associated with discoid and subacute cutaneous lupus erythematosus.

  19966805   The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes.

  20112030   Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility.

  20392289   Genetic associations in type I interferon related pathways with autoimmunity.

  20885991   Advances and challenges in biomarker development for type 1 diabetes prediction and prevention using omic technologies.

  21140222   Meta-analysis of TYK2 gene polymorphisms association with susceptibility to autoimmune and inflammatory diseases.

  21980299   A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.

  22046141   Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus.

  22536486   Lupus nephritis: an overview of recent findings.

  22541939   Bias in effect size of systemic lupus erythematosus susceptibility loci across Europe: a case-control study.

  22592861   Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus: a meta-analysis.

  23000200   TYK2 rs34536443 polymorphism is associated with a decreased susceptibility to endometriosis-related infertility.

  23049788   Further evidence of subphenotype association with systemic lupus erythematosus susceptibility loci: a European cases only study.

  23227085   Genetics of SLE: functional relevance for monocytes/macrophages in disease.

  24033266   A systematic approach to assessing the clinical significance of genetic variants.

  24653663   Systemic Lupus Erythematosus: Old and New Susceptibility Genes versus Clinical Manifestations.

  24946689   Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus.

  25147926   Cellular adhesion gene SELP is associated with rheumatoid arthritis and displays differential allelic expression.

  25741868   Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

  25744728   Tyrosine kinase-2 gene polymorphism is associated with ulcerative colitis and Crohn's disease in the Turkish population.

  26294277   Genetic association and interaction between the IRF5 and TYK2 genes and systemic lupus erythematosus in the Han Chinese population.

  26338038   Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway.

  26980740   Association between TYK2 polymorphisms and susceptibility to autoimmune rheumatic diseases: a meta-analysis.

  28846454   GLIS3 and TYK2 Single Nucleotide Polymorphisms Are Not Associated with Dermatomyositis/Polymyositis in Chinese Han Population.

  29728633   The psoriasis-protective TYK2 I684S variant impairs IL-12 stimulated pSTAT4 response in skin-homing CD4+ and CD8+ memory T-cells.

  30171347   Comprehensive assessment of the association between genes on JAK-STAT pathway (IFIH1, TYK2, IL-10) and systemic lupus erythematosus: a meta-analysis.

  31434951   Catalytically Impaired TYK2 Variants are Protective Against Childhood- and Adult-Onset Systemic Lupus Erythematosus in Mexicans.

  31961910   Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage.

  33949620   Association of TYK2 polymorphisms with autoimmune diseases: A comprehensive and updated systematic review with meta-analysis.

  34225445   The rs2304256 Polymorphism in TYK2 Gene Is Associated with Protection for Type 1 Diabetes Mellitus.

  34248934   Association of GTF2I, NFKB1, and TYK2 Regional Polymorphisms With Systemic Sclerosis in a Chinese Han Population.

  35382527   Genetics of systemic sclerosis.