SNP information rs2229616

Research and publications:

  12646666   Binge eating as a major phenotype of melanocortin 4 receptor gene mutations.

  14973783   Melanocortin-4 receptor gene variant I103 is negatively associated with obesity.

  15805150   Association of the 103I MC4R allele with decreased body mass in 7937 participants of two population based surveys.

  16278267   The 103I variant of the melanocortin 4 receptor is associated with low serum triglyceride levels.

  17356525   The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals.

  17357083   Medical sequencing at the extremes of human body mass.

  17519222   Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene.

  18239646   Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA Study.

  18377640   Val103Ile polymorphism of the melanocortin-4 receptor gene (MC4R) in cancer cachexia.

  18454148   Common variants near MC4R are associated with fat mass, weight and risk of obesity

  19696756   Association of the MC4R V103I polymorphism with obesity: a Chinese case-control study and meta-analysis in 55,195 individuals.

  19889825   Evidence that multiple genetic variants of MC4R play a functional role in the regulation of energy expenditure and appetite in Hispanic children.

  20092643   Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).

  20127379   From monogenic to polygenic obesity: recent advances.

  20530052   Melanocortin-4 receptor polymorphisms in Turkish pediatric obese patients.

  20935630   Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

  21750520   Implication of European-derived adiposity loci in African Americans.

  21750581   Genetic association of recovery from eating disorders: the role of GABA receptor SNPs.

  21848424   Genetic associations with metabolic syndrome and its quantitative traits by race/ethnicity in the United States.

  22020349   Polymorphisms of INSIG2, MC4R, and LEP are associated with obesity- and metabolic-related traits in schizophrenic patients.

  22310352   Genetic association study between antipsychotic-induced weight gain and the melanocortin-4 receptor gene.

  22535570   Is there a genetic cause of appetite loss?-an explorative study in 1,853 cancer patients.

  22989167   Association of melanocortin-4 receptor gene polymorphisms with obesity-related parameters in Malaysian Malays.

  23049848   Association between common polymorphism near the MC4R gene and obesity risk: a systematic review and meta-analysis.

  23101478   Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study.

  24518831   Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R.

  24820477   Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions.

  25741868   Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

  26474449   Practical Experience of the Application of a Weighted Burden Test to Whole Exome Sequence Data for Obesity and Schizophrenia.

  26788538   Allelic variants of the Melanocortin 4 receptor (MC4R) gene in a South African study group.

  29679223   Association between LEPR, FTO, MC4R, and PPARG-2 polymorphisms with obesity traits and metabolic phenotypes in school-aged children.

  30607769   Pharmacogenetic Correlates of Antipsychotic-Induced Weight Gain in the Chinese Population.

  31947684   The Effect Sizes of PPARγ rs1801282, FTO rs9939609, and MC4R rs2229616 Variants on Type 2 Diabetes Mellitus Risk among the Western Saudi Population: A Cross-Sectional Prospective Study.

  32114639   Genetic determinants of gestational diabetes mellitus: a case-control study in two independent populations.

  32921795   Obesity treatment effect in Danish children and adolescents carrying Melanocortin-4 Receptor mutations.

  32952152   Evaluation of the MC4R gene across eMERGE network identifies many unreported obesity-associated variants.

  33362866   Identification of a Rare and Potential Pathogenic MC4R Variant in a Brazilian Patient With Adulthood-Onset Severe Obesity.