SNP information rs1049296

Research and publications:

  9272172   Human transferrin (Tf): a single mutation at codon 570 determines Tf C1 or Tf C2 variant.

  14757931   The transferrin C2 variant does increase the risk of Alzheimer's disease in Caucasians.

  15060098   Synergy between the transferrin C2 allele and the C282Y allele of the hemochromatosis gene (HFE) as risk factors for the development of Alzheimer's disease.

  17357082   Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms.

  17601350   A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

  18779388   Assessing the potential for excess of statistically significant results in published genetic association studies: Application to Alzheimer's disease.

  18795173   Variants in iron metabolism genes predict higher blood lead levels in young children.

  18813964   Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta.

  18830724   Assessing case-control associations of Alzheimer's disease using family-based methods.

  19084216   Association of genetic variants at 3q22 with nephropathy in patients with type 1 diabetes mellitus.

  19165391   Iron metabolism genes, low-level lead exposure, and QT interval.

  19673882   A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis.

  19879291   Environmental manganese exposure in residents living near a ferromanganese refinery in Southeast Ohio: a pilot study.

  20029940   Proposed synergy between TF and u200bu200bHFE genetic variants as risk factors for Alzheimer's disease.

  20534741   Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.

  20574532   Intermediate phenotypes define different pathways in the development of Alzheimer's disease.

  20659343   HFE gene variants modify the association between maternal lead burden and infant birthweight: a prospective birth cohort study in Mexico City, Mexico.

  21537449   Genome-wide association analysis suggests that ACE is a risk factor for Alzheimer's disease and does not replicate most candidates from the meta-analysis.

  21665994   Genome-wide association study identifies two loci strongly affecting transferrin glycosylation.

  22074419   Associations of iron metabolism genes with blood manganese levels: a population-based study with validation data from animal models.

  23386860   Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes.

  23573206   Genetic loci associated with Alzheimer's disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort.

  23732512   Effect modification by transferrin C2 polymorphism on lead exposure, hemoglobin levels, and IQ.

  23820649   Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease

  23935582   The effect of hemochromatosis and transferrin gene mutations on peripheral iron dyshomeostasis in mild cognitive impairment and Alzheimer's and Parkinson's diseases.

  23968943   Meta-analysis on the association between the TF gene rs1049296 and AD.

  23996192   Toenail iron, genetic determinants of iron status, and the risk of glioma.

  24121126   Pooled analysis of iron-related genes in Parkinson's disease: association with transferrin.

  24391736   The contribution of diet and genotype to iron status in women: a classical twin study.

  25071582   HFE gene variants, iron and lipids: a novel link in Alzheimer's disease.

  25144566   Genetic variation in iron metabolism is associated with neuropathic pain and pain severity in HIV-infected patients on antiretroviral therapy.

  25287020   Maternal iron metabolism gene variants modify umbilical cord blood lead levels by gene-environment interaction: a birth cohort study.

  25649863   Identifying genetic interactions associated with late-onset Alzheimer's disease.

  25887915   Whole genome sequencing of an ethnic Pathan (Pakhtun) from the north-west of Pakistan.

  27255824   Determinants of iron accumulation in the normal aging brain.

  27437086   Allele Frequencies of the Single Nucleotide Polymorphisms Related to the Body Burden of Heavy Metals in the Korean Population and Their Ethnic Differences.

  29201641   Iron-related gene variants and brain iron in multiple sclerosis and healthy individuals.

  31936202   The Prevalence of Insomnia and the Link between Iron Metabolism Genes Polymorphisms, TF rs1049296 C>T, TF rs3811647 G>A, TFR rs7385804 A>C, HAMP rs10421768 A>G and Sleep Disorders in Polish Individuals with ASD.

  32143980   Failure to detect synergy between transferrin and hemochromatosis variants and Alzheimer's disease in a large cohort.

  35682458   Hepcidin (rs10421768), Transferrin (rs3811647, rs1049296) and Transferrin Receptor 2 (rs7385804) Gene Polymorphism Might Be Associated with the Origin of Multiple Sclerosis.