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SNP information rs872071

RS872071

Normal allele: AA

The IRF4 rs872071 polymorphism causes susceptibility to chronic lymphocytic leukaemia, Hodgkin's lymphoma, skin cancer and haematological malignancies.

Polymorphism rs872071 is related to topics like this:

Melanoma genes

The incidence of malignant melanoma (MM) is rising sharply, making it one of the most aggressive...

Leukemia is it genetic

Acute myeloid leukemia (AML) is a diverse cancer that primarily impacts individuals aged 60 and...


Research and publications:

  18758461   A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.

  19390683   Common gene variants in the tumor necrosis factor (TNF) and TNF receptor superfamilies and NF-kB transcription factors and non-Hodgkin lymphoma risk.

  19474294   Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

  19620980   Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma.

  19804451   IRF4 polymorphism rs872071 and risk of Hodgkin lymphoma.

  20332261   Genetic susceptibility variants for chronic lymphocytic leukemia.

  20389242   Familial chronic lymphocytic leukemia.

  20585100   Genome-wide association studies of cancer.

  20585627   Web-based, participant-driven studies yield novel genetic associations for common traits.

  20602913   IRF4 variants have age-specific effects on nevus count and predispose to melanoma.

  20639881   Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.

  20731705   Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong.

  20855867   Inherited genetic susceptibility to monoclonal B-cell lymphocytosis.

  21131588   Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL.

  21219822   [Recent progress in genetic variants associated with cancer and their implications in diagnostics development].

  21307401   What are genome-wide association studies telling us about B-cell tumor development?

  21659360   Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial.

  21859832   Interferon-signaling pathway: associations with colon and rectal cancer risk and subsequent survival.

  22235315   Post-GWAS functional characterization of susceptibility variants for chronic lymphocytic leukemia.

  23008714   Current understanding of lifestyle and environmental factors and risk of non-hodgkin lymphoma: an epidemiological update.

  23455380   Risk of genome-wide association study-identified genetic variants for non-Hodgkin lymphoma in a Chinese population.

  24292686   No evidence for a genetic association of IRF4 with systemic lupus erythematosus in a Chinese population.

  24906573   Association of interferon regulatory factor 4 gene polymorphisms rs12203592 and rs872071 with skin cancer and haematological malignancies susceptibility: a meta-analysis of 19 case-control studies.

  25261932   Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.

  26405224   Familial predisposition and genetic risk factors for lymphoma.

  27570521   Common Genetic Polymorphisms within NFκB-Related Genes and the Risk of Developing Invasive Aspergillosis.

  28083618   Cereblon and IRF4 Variants Affect Risk and Response to Treatment in Multiple Myeloma.

  33374413   Tracking the genetic susceptibility of B-cell non-Hodgkin's lymphomas based on genome-wide association studies.

  34981715   Expression of Programmed Cell Death 1 and Helios Genes Correlates With rs872071A>G and rs12203592C>T Single-Nucleotide Polymorphisms of InterferonRegulatory Factor 4 in Patients with T-Cell-Mediated Rejection of Renal Allograft.

Genetic testing for cancer

Medical tests are employed to detect specific changes or mutations in an individual's genes and...

Colorectal cancer genes

One of the prevalent cancer syndromes that can be inherited is colon cancer. Chromosome 2 contains...

Gastrointestinal tract cancer

The occurrence of gastrointestinal (GI) tract cancers caused by genetic mutations is widespread...

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