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SNP information rs3135391

RS3135391

Normal allele: GG

The major histocompatibility class I locus contributes to susceptibility to multiple sclerosis (3-6 times higher risk).

Polymorphism rs3135391 is related to topics like this:

Is multiple sclerosis hereditary disease

The presence of lesions on the brain and spinal cord is indicative of multiple sclerosis, a...

Research and publications:

  19143815   MHC fine mapping of human type 1 diabetes using the T1DGC data.

  19846760   Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.

  20593013   A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.

  21826374   Selective IgA deficiency in autoimmune diseases.

  22170232   Amino acid position 11 of HLA-DRĪ²1 is a major determinant of chromosome 6p association with ulcerative colitis.

  22277159   Implications for health and disease in the genetic signature of the Ashkenazi Jewish population.

  22761632   Role of MHC-linked susceptibility genes in the pathogenesis of human and murine lupus.

  23326239   A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1).

Dementia is genetic

Dementia is characterized as a syndrome, rather than a singular disease. Individuals with early...

Alzheimer's disease is hereditary

Alzheimer's disease is a degenerative brain disease that causes dementia, resulting in a gradual...

Is OCD obsessive compulsive disorder genetic

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by features known as...

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