SNP information rs2359612

Research and publications:

  15883587   Common VKORC1 and GGCX polymorphisms associated with warfarin dose.

  16270629   VKORC1 haplotypes and their impact on the inter-individual and inter-ethnical variability of oral anticoagulation.

  16611750   Polymorphisms in the VKORC1 gene are strongly associated with warfarin dosage requirements in patients receiving anticoagulation.

  17048007   Association of warfarin dose with genes involved in its action and metabolism

  17391071   Factors affecting the interindividual variability of warfarin dose requirement in adult Korean patients.

  17549303   Functional promoter polymorphism in the VKORC1 gene is no major genetic determinant for coronary heart disease in Northern Germans.

  18030307   Combination of phenotype assessments and CYP2C9-VKORC1 polymorphisms in the determination of warfarin dose requirements in heavily medicated patients.

  18252229   Warfarin pharmacogenetics: CYP2C9 and VKORC1 genotypes predict different sensitivity and resistance frequencies in the Ashkenazi and Sephardi Jewish populations.

  18322281   Genetic determinants of response to warfarin during initial anticoagulation.

  18466099   Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans.

  18523153   Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement.

  18559094   Warfarin dose and INR related to genotypes of CYP2C9 and VKORC1 in patients with myocardial infarction.

  18574025   The largest prospective warfarin-treated cohort supports genetic forecasting

  18752379   Warfarin pharmacogenetics.

  18841283   Single nucleotide polymorphisms in the VKORC1 gene and the risk of stroke in the Southern German population.

  18855533   VKORC1 polymorphisms, haplotypes and haplotype groups on warfarin dose among African-Americans and European-Americans.

  19074728   Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy.

  19228618   Estimation of the warfarin dose with clinical and pharmacogenetic data.

  19300499   A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.

  19738376   Pharmacogenetic testing for guiding de novo phenprocoumon therapy in stroke patients.

  19955245   Warfarin sensitivity genotyping: a review of the literature and summary of patient experience.

  20128861   Comparative performance of gene-based warfarin dosing algorithms in a multiethnic population.

  20203262   Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups.

  20716240   New genetic variant that might improve warfarin dose prediction in African Americans.

  21179214   VKORC1 pharmacogenetics and pharmacoproteomics in patients on warfarin anticoagulant therapy: transthyretin precursor as a potential biomarker.

  21179439   VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey.

  21270790   The missing association: sequencing-based discovery of novel SNPs in VKORC1 and CYP2C9 that affect warfarin dose in African Americans.

  21326313   Proposal of pharmacogenetics-based warfarin dosing algorithm in Korean patients.

  21672908   Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin.

  22135769   Gene-drug interaction in stroke.

  22178823   [Distribution of variant alleles association with warfarin pharmacokinetics and pharmacodynamics in the Han population in China].

  22329724   Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record.

  22676711   Pharmacogenomics of warfarin in populations of African descent.

  22912647   Liver expression quantitative trait loci: a foundation for pharmacogenomic research.

  22952875   Influence of CYP2C9 and VKORC1 on patient response to warfarin: a systematic review and meta-analysis.

  22992668   Pharmacogenomics knowledge for personalized medicine.

  23016735   Personalized approach of medication by indirect anticoagulants tailored to the patient-Russian context: what are the prospects?

  23285254   Positive selection in the chromosome 16 VKORC1 genomic region has contributed to the variability of anticoagulant response in humans.

  23588304   Replication of TPMT and ABCC3 genetic variants highly associated with cisplatin-induced hearing loss in children.

  24019055   Effect of CYP2C9, VKORC1, CYP4F2 and GGCX genetic variants on warfarin maintenance dose and explicating a new pharmacogenetic algorithm in South Indian population.

  24944790   Screening for 392 polymorphisms in 141 pharmacogenes.

  26444257   Genetic diversity of variants involved in drug response and metabolism in Sri Lankan populations: implications for clinical implementation of pharmacogenomics.

  26600534   VKORC1 rs2359612 and rs9923231 polymorphisms correlate with high risks of cardiovascular and cerebrovascular diseases.

  27703968   G-1639A but Not C1173T VKORC1 Gene Polymorphism Is Related to Ischemic Stroke and Its Various Risk Factors in Ukrainian Population.

  27889279   Vitamin K epoxide reductase expression and prostate cancer risk.

  28771511   Exploring public genomics data for population pharmacogenomics.

  30712247   Interpretation of the effect of CYP2C9, VKORC1 and CYP4F2 variants on warfarin dosing adjustment in Turkey.

  31114289   VKORC1 variants as significant predictors of warfarin dose in Emiratis.

  31293107   Effect of gene-gene and gene-environment interaction on the risk of first-ever stroke and poststroke death.

  31869433   Genetic Factors Influencing Warfarin Dose in Black-African Patients: A Systematic Review and Meta-Analysis.

  32326111   Role of Genetic Variations in the Hepatic Handling of Drugs.

  33519226   Genetic Diversity of Drug-Related Genes in Native Americans of the Brazilian Amazon.

  33958549   Genetic Associations With Stable Warfarin Dose Requirements in Han Chinese Patients.

  34824904   Genetic diversity of "highly important pharmacogenes" in two South Asian populations.

  35337356   Cross-ethnic analysis of common gene variants in hemostasis show lopsided representation of global populations in genetic databases.