Normal allele: AA
The striatal polymorphism of the D2 receptor is a novel genetic marker of multiple addiction phenotypes: alcohol, nicotine, heroin and opioid dependence.
Polymorphism rs12364283 is related to topics like this:
DopamineADHD (Attention Deficit Hyperactivity Disorder)Drug dependence
Research and publications:
18077373 Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.
18821566 SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families.
18829695 Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia.
19373123 Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution.
19393722 Genetic contributions to avoidance-based decisions: striatal D2 receptor polymorphisms.
19512960 Genetic diagnostics of functional variants of the human dopamine D2 receptor gene.
19693267 Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.
19968402 Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensation seeking: an exploratory study with d-amphetamine in healthy participants.
21150907 Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse.
21168125 TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood
21289622 Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapy.
21333900 The role of genetics in IBS
21906503 Different phenotypic and genotypic presentations in alcohol dependence: age at onset matters.
21948099 Can the chronic administration of the combination of buprenorphine and naloxone block dopaminergic activity causing anti-reward and relapse potential?
22021758 Interaction of early environment, gender and genes of monoamine neurotransmission in the aetiology of depression in a large population-based Finnish birth cohort.
22424959 DRD2 polymorphisms modulate reward and emotion processing, dopamine neurotransmission and openness to experience.
22579533 Binge eating disorder and the dopamine D2 receptor: genotypes and sub-phenotypes.
22963930 Custom genotyping for substance addiction susceptibility genes in Jordanians of Arab descent.
23647975 PTSD risk associated with a functional DRD2 polymorphism in heroin-dependent cases and controls is limited to amphetamine-dependent individuals.
24410775 Moderator effects of working memory on the stability of ADHD symptoms by dopamine receptor gene polymorphisms during development.
26044620 Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction.
26926883 Genetic variation and dopamine D2 receptor availability: a systematic review and meta-analysis of human in vivo molecular imaging studies.
26986136 The Association Between Genetic Variants in the Dopaminergic System and Posttraumatic Stress Disorder: A Meta-Analysis.
30093869 Biological Predictors of Clozapine Response: A Systematic Review.
30815277 Unravelling the interaction between the DRD2 and DRD4 genes, personality traits and concussion risk.
31025317 Significant association of DRD2 enhancer variant rs12364283 with heroin addiction in a Pakistani population.
31129315 Systematic Review and Meta-Analysis of Genetic Risk of Developing Chronic Postsurgical Pain.
33580321 Dopamine multilocus genetic profiles predict sex differences in reactivity of the human reward system.
35564336 Impact of the DRD2 Polymorphisms on the Effectiveness of the Training Program.