SNP information rs10954213

Research and publications:

  17189288   Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation.

  17393452   Structural insertion/deletion variation in IRF5 is associated with a risk haplotype and defines the precise IRF5 isoforms expressed in systemic lupus erythematosus.

  17412832   Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.

  18050197   Association of functional polymorphism of the IRF5 gene with Sjögren's syndrome.

  18063667   Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus.

  18200047   IFN-regulatory factor 5 gene variants interact with the class I MHC locus in the Swedish psoriasis population.

  18285424   Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations.

  18311811   Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: support for a crucial role of intron 1 polymorphisms.

  18668568   Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients.

  19019891   STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk.

  19440199   Recent insights into the genetic basis of systemic lupus erythematosus.

  19479858   Association of a functional polymorphism in the IRF5 region with systemic sclerosis in a Japanese population.

  19567624   Evidence for genetic association and interaction between the TYK2 and IRF5 genes in systemic lupus erythematosus.

  19644876   Association of STAT4 and BLK, but not BANK1 or IRF5, with primary antiphospholipid syndrome.

  19758313   Tyrosine kinase 2 and interferon regulatory factor 5 polymorphisms are associated with discoid and subacute cutaneous lupus erythematosus.

  19772658   Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation.

  19854706   Association of IRF5 polymorphisms with activation of the interferon alpha pathway.

  20080916   Promoter insertion/deletion in the IRF5 gene is highly associated with susceptibility to systemic lupus erythematosus in distinct populations, but exerts a modest effect on gene expression in peripheral blood mononuclear cells.

  20112383   Genetic variants and disease-associated factors contribute to enhanced interferon regulatory factor 5 expression in blood cells of patients with systemic lupus erythematosus.

  20137629   [Relationship between polymorphism sites of IRF5, TLR-9 and SLE patients in Shandong Han population].

  20231204   Phenotype-haplotype correlation of IRF5 in systemic sclerosis: role of 2 haplotypes in disease severity.

  20392289   Genetic associations in type I interferon related pathways with autoimmunity.

  20479942   Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap.

  20639879   Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.

  20652065   Interferon alpha in systemic lupus erythematosus.

  20691091   Survival dimensionality reduction (SDR): development and clinical application of an innovative approach to detect epistasis in presence of right-censored data.

  20881011   Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients.

  20933377   Recent findings on genetics of systemic autoimmune diseases.

  20980283   The interferon regulatory factor 5 gene confers susceptibility to rheumatoid arthritis and influences its erosive phenotype.

  21060334   Genetic susceptibility to systemic lupus erythematosus in the genomic era.

  21497524   Genetics and genomics of Sjögren's syndrome: research provides clues to pathogenesis and new treatment methods.

  21627826   Cis-regulation of IRF5 expression is unable to fully account for systemic lupus erythematosus association: analysis of multiple experiments with lymphoblastoid cell lines.

  21834935   A meta-analysis of the association of IRF5 polymorphism with systemic lupus erythematosus.

  21968701   Interferon regulatory factor 5 activation in monocytes of systemic lupus erythematosus patients is triggered by circulating autoantigens independent of type I interferons.

  22088620   IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus.

  22110124   Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus.

  22162633   Activation of type I interferon pathway in systemic lupus erythematosus: association with distinct clinical phenotypes.

  22257839   A two-marker haplotype in the IRF5 gene is associated with inflammatory bowel disease in a North American cohort.

  22427729   Inherited variation in pattern recognition receptors and cancer: dangerous liaisons?

  22440820   IRF5 polymorphism predicts prognosis in patients with systemic sclerosis.

  22536486   Lupus nephritis: an overview of recent findings.

  22544929   IRF5 risk polymorphisms contribute to interindividual variance in pattern recognition receptor-mediated cytokine secretion in human monocyte-derived cells.

  22640752   The genetics of lupus: a functional perspective.

  22654485   Role of cytokines in systemic lupus erythematosus: recent progress from GWAS and sequencing.

  22909381   IRF5 gene polymorphisms in melanoma.

  23049601   Genetics of myasthenia gravis: a case-control association study in the Hellenic population.

  23227085   Genetics of SLE: functional relevance for monocytes/macrophages in disease.

  23251221   Interferon regulatory factor 5 in the pathogenesis of systemic lupus erythematosus.

  23288367   Interferon regulatory factor 5 polymorphisms in sarcoidosis.

  23349905   RNA-Seq for enrichment and analysis of IRF5 transcript expression in SLE.

  23372721   The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis.

  23392701   Association of rs10954213 polymorphisms and haplotype diversity in interferon regulatory factor 5 with systemic lupus erythematosus: a meta-analysis.

  23818875   DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and non-coding transcripts.

  23941291   Identification of three new cis-regulatory IRF5 polymorphisms: in vitro studies.

  24653663   Systemic Lupus Erythematosus: Old and New Susceptibility Genes versus Clinical Manifestations.

  24697591   Association of interferon regulatory factor 5 (IRF5) markers with an increased risk of lupus and overlapping autoimmunity in a Kuwaiti population.

  24946689   Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus.

  25106527   Genome-wide association study combined with biological context can reveal more disease-related SNPs altering microRNA target seed sites.

  25328554   Systemic Sclerosis is a Complex Disease Associated Mainly with Immune Regulatory and Inflammatory Genes.

  25564941   Association between genetic polymorphisms of the interferon regulatory factor 5 (IRF5) gene and Malaysian patients with Crohn's disease.

  25685889   Identification of common genetic variants controlling transcript isoform variation in human whole blood.

  26106387   Pathogenesis of Systemic Sclerosis.

  26294277   Genetic association and interaction between the IRF5 and TYK2 genes and systemic lupus erythematosus in the Han Chinese population.

  26857698   Genome-wide analysis of DNA methylation in multiple tissues in primary Sjögren's syndrome reveals regulatory effects of interferon-induced genes.

  26880555   Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity.

  27324920   Complex Selection on Human Polyadenylation Signals Revealed by Polymorphism and Divergence Data.

  27798840   Interferon Regulatory Factor 5 Gene Polymorphisms in Iranian Women with Unexplained Recurrent Pregnancy Loss.

  28059021   Interferon regulatory factor 5 gene polymorphism in Egyptian children with systemic lupus erythematosus.

  29423720   Association of interferon regulatory factor 5 (IRF5) gene polymorphisms with juvenile idiopathic arthritis.

  29476163   Genetic predictors of systemic sclerosis-associated interstitial lung disease: a review of recent literature.

  29867973   Lineage-Specific Functionality of an Interferon Regulatory Factor 5 Lupus Risk Haplotype: Lack of B Cell Intrinsic Effects.

  30168487   The IRF5 rs2004640 (G/T) polymorphism is not a genetic risk factor for systemic lupus erythematosus in population from south India.

  30176312   Genetic variants of interferon regulatory factor 5 associated with the risk of community-acquired pneumonia.

  31877114   IRF5 genetic risk variants drive myeloid-specific IRF5 hyperactivation and presymptomatic SLE.

  31916109   Defining genetic risk factors for scleroderma-associated interstitial lung disease : IRF5 and STAT4 gene variants are associated with scleroderma while STAT4 is protective against scleroderma-associated interstitial lung disease.

  32441646   Role of IRF5 in the pathogenesis of immunoglobulin-A vasculitis.

  33583939   Polymorphisms in IRF5 and TYK2 Genes Are Associated with Rheumatoid Arthritis in a Chinese Han Population.

  34484216   Alternative Splicing: A New Cause and Potential Therapeutic Target in Autoimmune Disease.

  35382527   Genetics of systemic sclerosis.