SNP information rs10045431

Research and publications:

  17587057   Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.

  18438406   Genetic determinants of ulcerative colitis include the ECM1 locus and five loci involved in Crohn's disease.

  18587394   Genome-wide association identifies more than 30 different susceptibility loci for Crohn's disease.

  19068216   Investigation of Crohn's disease risk loci in ulcerative colitis further determines their molecular relatedness.

  19468064   Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.

  19557189   Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions

  20228799   Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

  20570966   Nonsecretory fucosyltransferase 2 (FUT2) status is associated with Crohn's disease.

  20805105   Synthetic associations in the context of genome-wide association scan signals

  21152001   The association of 1q32 and STAT3 variants with ankylosing spondylitis suggests genetic overlap with Crohn's disease.

  21304977   An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.

  21333900   The role of genetics in IBS

  21487504   Immunopathogenesis of inflammatory bowel disease.

  21548950   Evaluation of 22 genetic variants with risk for Crohn's disease in an Ashkenazi Jewish population: a case-control study.

  21730793   The influence of risk alleles for Crohn's disease and smoking on the location of the disease.

  21752155   Genetic susceptibility to inflammation and colonic transit in lower functional gastrointestinal disorders: preliminary analysis.

  21830272   Different and overlapping genetic loci in Crohn's disease and ulcerative colitis: correlation with pathogenesis.

  21852963   Pervasive sharing of genetic effects in autoimmune disease.

  22194214   Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes.

  22275320   Pattern recognition receptor and autophagy gene variants are associated with antimicrobial antibody production in Crohn's disease.

  22479607   Analysis of IL12B gene variants in inflammatory bowel disease.

  23280621   Nucleotide variation in IL-10 and IL-12 and their receptors and cervical and vulvar cancer risk: a hybrid case-parent triad and case-control study.

  23300620   Genotype/phenotype analysis of 53 genetic polymorphisms associated with Crohn's disease.

  24522266   The detection of Mycobacterium avium subspecies paratuberculosis in patients with Crohn's disease is not associated with the presence of single nucleotide polymorphisms rs2241880 (ATG16L1) and rs10045431 (IL12B).

  24859272   Genetic variations of IL-12B, IL-12Rβ1, IL-12Rβ2 in Behçet's disease and VKH syndrome.

  24917882   Genetic-based prediction of disease traits: prediction is very difficult, especially about the future.

  25133031   Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature.

  25587358   Complex host genetics influence the microbiome in inflammatory bowel disease.

  26103568   Association Study of IL-12B Polymorphisms Susceptibility with Ankylosing Spondylitis in Mainland Han Population.

  26663019   Genetic variations in interleukin-12B in allergic rhinitis.

  27532455   Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.

  29967744   Association of Crohn's disease-associated chromosome 1q32 with ankylosing spondylitis is independent of bowel symptoms and fecal calprotectin.

  30568945   Genetic associations of inflammatory bowel disease in a South Asian population.

  32947150   Association between IL12B polymorphisms and inflammatory bowel disease in Caucasian population: A meta-analysis.

  33390082   The Polymorphisms of Interleukin-12B Gene and Susceptibility to Inflammatory Bowel Diseases: A Meta-analysis and Trial Sequential Analysis.

  34539646   Targeting the Interleukin-23/Interleukin-17 Inflammatory Pathway: Successes and Failures in the Treatment of Axial Spondyloarthritis.