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Genetic digestive disorders


By Li Dali, Ph.D.

If you tested your DNA with a personal genomics service like 23andMe, AncestryDNA, FamilyTreeDNA, MyHeritage or another testing company, you can learn more about your risk factors for hundreds of diseases. By clicking the button above ⬆️, you can upload your raw DNA data file and receive a personalized 250-page health report with research links that is the most comprehensive.

Numerous gastrointestinal disorders exhibit an inherited nature or entail a genetic predisposition in their manifestation. In light of recent studies, the genes accountable for several of these ailments have been revealed. Consequently, genetic testing is now accessible for diagnosing certain conditions and detecting symptomless relatives.

The origin of conditions like irritable bowel disease, Chron's disease, and ulcerative colitis can be traced back to an excessive inflammatory reaction in the intestinal wall, which is largely influenced by cytokines - immune proteins that actively contribute to the inflammation.

Likewise, for irritable bowel disease, there were identified SNPs in the gene that encodes a specific inflammatory cytokine. This SNP resulted in an excessive production of the cytokine in the bowel, which triggered a hyperinflammatory reaction. It is noteworthy that a distinct SNP in the same gene was found to be associated with a higher likelihood of developing gastric cancer.


The gene's protein is thought to have a function in directing the development and specialization of epithelial cells, as well as contributing to the initiation of tumors.

The gene symbol IL23R.

The receptor for the immune response protein IL-23 is known as IL23R.

TCF7L2 can be rewritten as Transcription Factor 7 Like 2.

The regulation of various cellular processes, such as the synthesis of glucagon in the pancreas, is under the control of TCF7L2, a transcription factor.

MADD is believed to oversee regulated cell death, while also being involved in various other cellular processes.

The liver produces a protein called GCKR that controls the metabolism of glucose.

ADRA2A can be rewritten as the alpha-2A adrenergic receptor.

The regulation of neurotransmitter release is significantly influenced by the receptor ADRA2A.

ADCY5 can be rewritten as Adenylate Cyclase 5.

The enzyme ADCY5 regulates cellular activity based on the levels of glucose present.

SLC2A14 can be rewritten as the gene symbol for solute carrier family 2 member 14.

The protein SLC2A14 functions as a transporter, facilitating the entry of glucose into cells.

The transsulfuration pathway involves the conversion of cystathionine into cysteine, which is facilitated by the enzyme CTH in the second step.

The immune system relies significantly on the function of NOD2.

SLC19A1 can be rewritten as the gene symbol for the solute carrier family 19 member 1.

The transporter for folate is known as SLC19A1.

Your gut health is influenced by more than just genetics. Other factors such as diet, lifestyle, and environment play a significant role. The food we eat on a daily basis has a direct impact on our gut health. A diet rich in fiber can help protect against conditions like IBD, IBS, and acid reflux. Conversely, consuming too much red and processed meat can increase the risk of developing diverticulitis, inflammatory bowel disease, and colon cancer.

It is crucial to prioritize adequate exercise and sleep to maintain a healthy gut system. Additionally, safeguarding ourselves from environmental factors is essential, including minimizing exposure to viral infections.

            Crohn's disease