Normal allele: AA
The chronic hepatitis B risk allele is associated with reduced expression of HLA-DPA1 and HLA-DPB1 mRNA in normal human liver. Allows prediction of recovery from hepatitis B virus infection. Also affects both hepatitis C virus persistence and hepatitis C virus F protein formation.
Polymorphism rs9277535 is related to topics like this:
Research and publications:
19458352 Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.
19812545 Origins and functional impact of copy number variation in the human genome.
20639879 Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.
21049023 A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis.
22496224 A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection.
23730204 Progress in multiple sclerosis genetics.
24023482 HLA class II associated with outcomes of hepatitis B and C infections.
24659896 Acute hepatitis B of genotype H resulting in persistent infection.
24665059 Mapping of hepatic expression quantitative trait loci (eQTLs) in a Han Chinese population.
24976707 Human genes involved in hepatitis B virus infection.
25802187 Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B.
26563120 Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update.
27243039 Clinical Relevance of HLA Gene Variants in HBV Infection.
27394003 Association of HLA-DP/DQ and STAT4 polymorphisms with ankylosing spondylitis in Southwest China.
27595289 Novel HLA-DP region susceptibility loci associated with severe acute GvHD.
27621573 Current hepatitis B virus infection situation in Indonesia and its genetic diversity.
27795724 Host Genetic Variants in HLA Loci Influence Risk for Hepatitis B Virus Infection in Children.
28449694 The MHC locus and genetic susceptibility to autoimmune and infectious diseases.
29300980 Distinct Relapse Rates and Risk Predictors After Discontinuing Tenofovir and Entecavir Therapy.
30009173 Association between HLA-DP Gene Polymorphisms and Cervical Cancer Risk: A Meta-Analysis.
31475028 Host Genetic Determinants of Hepatitis B Virus Infection.
33710355 Variation and expression of HLA-DPB1 gene in HBV infection.