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SNP information rs9277535

RS9277535

Normal allele: AA

The chronic hepatitis B risk allele is associated with reduced expression of HLA-DPA1 and HLA-DPB1 mRNA in normal human liver. Allows prediction of recovery from hepatitis B virus infection. Also affects both hepatitis C virus persistence and hepatitis C virus F protein formation.

Polymorphism rs9277535 is related to topics like this:

Hepatitis genetic

Genetic factors can play an important role in treatment response and disease progression in chronic...


Research and publications:

  19458352   Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.

  19812545   Origins and functional impact of copy number variation in the human genome.

  20436909   The textile plot: a new linkage disequilibrium display of multiple-single nucleotide polymorphism genotype data.

  20639879   Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.

  21049023   A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis.

  21274863   Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population.

  21310144   Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment.

  21346778   Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver.

  21408128   Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies.

  21750111   A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.

  21764829   A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region.

  22105689   Genetic variants in human leukocyte antigen/DP-DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development.

  22363396   HBV-related hepatocellular carcinoma susceptibility gene KIF1B is not associated with development of chronic hepatitis B.

  22448225   A common HLA-DPA1 variant is associated with hepatitis B virus infection but fails to distinguish active from inactive Caucasian carriers.

  22496224   A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection.

  22543033   Relationship between HLA-DP gene polymorphisms and clearance of chronic hepatitis B virus infections: case-control study and meta-analysis.

  22737229   Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.

  23428460   Genetic variants in HLA-DP/DQ contribute to risk of cervical cancer: a two-stage study in Chinese women.

  23601003   Association of the rs3077 and rs9277535 polymorphisms in HLA-DP with hepatitis B virus infection and spontaneous clearance: a meta-analysis.

  23730204   Progress in multiple sclerosis genetics.

  24006435   HLA-DP polymorphisms affect the outcomes of chronic hepatitis B virus infections, possibly through interacting with viral mutations.

  24023482   HLA class II associated with outcomes of hepatitis B and C infections.

  24298935   Effect of HLA-DP and IL28B gene polymorphisms on response to interferon treatment in hepatitis B e-antigen seropositive chronic hepatitis B patients.

  24367763   Human leukocyte antigens and epstein-barr virus-associated nasopharyngeal carcinoma: old associations offer new clues into the role of immunity in infection-associated cancers.

  24659896   Acute hepatitis B of genotype H resulting in persistent infection.

  24665059   Mapping of hepatic expression quantitative trait loci (eQTLs) in a Han Chinese population.

  24846544   Association of variants in HLA-DP on chromosome 6 with chronic hepatitis B virus infection and related phenotypes.

  24897020   Genetic variants in human leukocyte antigen-DP influence both hepatitis C virus persistence and hepatitis C virus F protein generation in the Chinese Han population.

  24940741   A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese.

  24959916   Differences in meiotic recombination rates in childhood acute lymphoblastic leukemia at an MHC class II hotspot close to disease associated haplotypes.

  24976707   Human genes involved in hepatitis B virus infection.

  25041342   Association of HLA-DP/DQ, STAT4 and IL-28B variants with HBV viral clearance in Tibetans and Uygurs in China.

  25103089   HLA-DP genes polymorphisms associate with hepatitis B surface antigen kinetics and seroclearance during nucleot(s)ide analogue therapy.

  25365208   Association of HLA-DP/DQ and STAT4 polymorphisms with HBV infection outcomes and a mini meta-analysis.

  25449085   [Studies on the association of single nucleotide polymorphisms of HLA-DP and DQ genes with the outcome of chronic hepatitis B virus infection].

  25469587   Interaction of TLR-IFN and HLA polymorphisms on susceptibility of chronic HBV infection in Southwest Han Chinese.

  25802187   Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B.

  26197724   Fine mapping analysis of HLA-DP/DQ gene clusters on chromosome 6 reveals multiple susceptibility loci for HBV infection.

  26462556   Quantitative assessment of common genetic variations in HLA-DP with hepatitis B virus infection, clearance and hepatocellular carcinoma development.

  26563120   Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update.

  26769676   Fine mapping the MHC region identified four independent variants modifying susceptibility to chronic hepatitis B in Han Chinese.

  27051043   Protective effects of HLA-DPA1/DPB1 variants against Hepatitis B virus infection in an Indonesian population.

  27075395   Hepatitis B virus mutations, expression quantitative trait loci for PTPN12, and their interactions in hepatocellular carcinoma.

  27083422   Association of HLA-DP variants with the responsiveness to Hepatitis B virus vaccination in Korean Infants.

  27123247   Association between the HLA-DQB1 polymorphisms and the susceptibility of chronic hepatitis B: A comprehensive meta-analysis.

  27243039   Clinical Relevance of HLA Gene Variants in HBV Infection.

  27244555   Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese.

  27291710   Association of human leukocyte antigen DP/DQ gene polymorphisms with chronic hepatitis B in Chinese Han and Uygur populations.

  27394003   Association of HLA-DP/DQ and STAT4 polymorphisms with ankylosing spondylitis in Southwest China.

  27595289   Novel HLA-DP region susceptibility loci associated with severe acute GvHD.

  27621573   Current hepatitis B virus infection situation in Indonesia and its genetic diversity.

  27795724   Host Genetic Variants in HLA Loci Influence Risk for Hepatitis B Virus Infection in Children.

  28094303   Genetic Polymorphisms of rs3077 and rs9277535 in HLA-DP associated with Systemic lupus erythematosus in a Chinese population.

  28119119   Association between chronic hepatitis B virus infection and HLA-DP gene polymorphisms in the Turkish population.

  28429786   Comprehensive assessment showed no associations of variants at the SLC10A1 locus with susceptibility to persistent HBV infection among Southern Chinese.

  28449694   The MHC locus and genetic susceptibility to autoimmune and infectious diseases.

  28613373   Lack of association between human leukocyte antigen polymorphisms rs9277535 and rs7453920 and chronic hepatitis B in a Brazilian population.

  28640108   Correlation of HLA-DP/DQ polymorphisms with transplant etiologies and prognosis in liver transplant recipients.

  28834572   Multiple genetic variants associated with posttransplantation diabetes mellitus in Chinese Han populations.

  28882445   Strong influence of human leukocyte antigen-DP variants on response to hepatitis B vaccine in a Japanese population.

  29061159   Genetic polymorphisms of HLA-DP and isolated anti-HBc are important subsets of occult hepatitis B infection in Indonesian blood donors: a case-control study.

  29212520   The relationship between human leukocyte antigen-DP/DQ gene polymorphisms and the outcomes of HCV infection in a Chinese population.

  29300980   Distinct Relapse Rates and Risk Predictors After Discontinuing Tenofovir and Entecavir Therapy.

  29404438   A global perspective on hepatitis B-related single nucleotide polymorphisms and evolution during human migration.

  29451182   Host genetic factors in predicting response status in chronic hepatitis B patients discontinuing nucleos(t)ide analogs.

  29467950   Genetic polymorphisms in HLA-DP and STAT4 are associated with IgA nephropathy in a Southwest Chinese population.

  29476350   Genetic polymorphism of rs9277535 in HLA-DP associated with rheumatoid arthritis and anti-CCP production in a Chinese population.

  30009173   Association between HLA-DP Gene Polymorphisms and Cervical Cancer Risk: A Meta-Analysis.

  30471179   Association of HLA-DPA1 and HLA-DPB1 polymorphisms with spontaneous HBsAg seroclearance in Caucasians.

  31475028   Host Genetic Determinants of Hepatitis B Virus Infection.

  32008865   Genetic variants in HLA-DP/DQ contribute to risk of acute myeloid leukemia: A case-control study in Chinese.

  32183599   Genetic polymorphisms of the HLA-DP and HLA-DQ genes could influence Hepatitis B virus infection in Yunnan population.

  33334325   A non-synonymous variant rs12614 of complement factor B associated with risk of chronic hepatitis B in a Korean population.

  33710355   Variation and expression of HLA-DPB1 gene in HBV infection.

  33875616   HLA-DPB1 rs9277535 polymorphism is associated with rheumatoid arthritis risk in a Chinese Han population.

  34712031   Hepatitis B virus persistent infection-related single nucleotide polymorphisms in HLA regions are associated with viral load in hepatoma families.

  35752129   Association of single nucleotide polymorphisms in immune-related genes with spontaneous HBsAg seroconversion: A systematic review and meta-analysis.

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