Normal allele: AA
Polymorphism rs8042374 is related to topics like this:
Cancer of respiratory organsTobacco addiction
Research and publications:
18414406 Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence
18519524 Variants in nicotinic receptors and risk for nicotine dependence
18978787 Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
19628476 Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15
19654303 Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.
19706762 The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans
19955392 Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers.
20585100 Genome-wide association studies of cancer.
21559498 Chromosome 15q25 (CHRNA3-CHRNA5) variation impacts indirectly on lung cancer risk
21949713 Genetics of sputum gene expression in chronic obstructive pulmonary disease.
23056235 Functional polymorphisms of CHRNA3 predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese.
23689675 Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents.
23870182 Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era.
24686516 CHRNA3 polymorphism modifies lung adenocarcinoma risk in the Chinese Han population.
25233467 Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma.
25302169 Acetylcholine receptor pathway in lung cancer: New twists to an old story.
25415319 Association of GWAS-identified lung cancer susceptibility loci with survival length in patients with small-cell lung cancer treated with platinum-based chemotherapy.
26831765 Association between two CHRNA3 variants and susceptibility of lung cancer: a meta-analysis.
26942719 Chromosome 15q25 (CHRNA3-CHRNB4) Variation Indirectly Impacts Lung Cancer Risk in Chinese Males.
27028512 Genetic Evaluation of Schizophrenia Using the Illumina HumanExome Chip.
27230571 Different dietary patterns and reduction of lung cancer risk: A large case-control study in the U.S.
28827732 Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies.
29942042 A decade in psychiatric GWAS research.