SNP information rs738409

Research and publications:

  18728122   Polymorphisms in the adiponutrin gene are associated with increased insulin secretion and obesity

  18820647   Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

  18940312   Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes

  19224197   A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans

  19524579   Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors

  19542081   A common variant in the adiponutrin gene influences liver enzyme values

  19651814   Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene

  19729411   Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteins

  19738004   A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity

  19844213   Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent

  19946271   Variant in PNPLA3 is associated with alcoholic liver disease

  20335584   Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease

  20373368   Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease

  20546964   The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life

  20585554   On the use of genotype variance as a tool for identifying quantitative effects of trait interactions: Report of the Women's Genome Health Study

  20609972   Lipid-induced insulin resistance: unravelling the mechanism

  20648472   PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease

  20648474   I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease

  20648554   Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease

  20684021   The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease

  20708005   Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease

  20803499   A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents

  20825652   Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study

  20826584   Specifically PNPLA3-mediated accumulation of liver fat in obese patients with type 2 diabetes

  20852027   Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescents

  20962157   Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption

  21068004   Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome

  21168155   A common variant in the PNPLA3 gene is a risk factor for non-alcoholic fatty liver disease in obese Taiwanese children

  21168459   Variant adiponutrin (PNPLA3) represents a common fibrosis risk gene: non-invasive elastography-based study in chronic liver disease

  21176169   Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease

  21236304   Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis

  21245030   Genetic determinants of hepatic steatosis in man

  21254164   Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians

  21274868   Dissociation between APOC3 variants, hepatic triglyceride content and insulin resistance

  21281435   Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study

  21319195   Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis C

  21334404   Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease

  21339799   Bioinformatics-driven identification and examination of candidate genes for non-alcoholic fatty liver disease

  21381068   Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

  21423719   Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits

  21488075   Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C

  21525193   Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans

  21533024   Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci

  21663607   Lack of effect of apolipoprotein C3 polymorphisms on indices of liver steatosis, lipid profile and insulin resistance in obese Southern Europeans

  21665509   Association of PNPLA3 SNP rs738409 with liver density in African Americans with type 2 diabetes mellitus

  21700865   Human fatty liver disease: old questions and new insights

  21868769   World Congress on Insulin Resistance, Diabetes, and Cardiovascular Disease: part 3

  22001757   Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

  22095588   Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease

  22105854   Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents

  22110053   Genetic determinants of alcoholic liver disease

  22141340   Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease

  22162034   PNPLA3 (rs738409 C>G) is a common risk variant associated with hepatocellular carcinoma in alcoholic cirrhosis

  22258181   A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease

  22314430   IL28B and PNPLA3 polymorphisms affect histological liver damage in patients with non-alcoholic fatty liver disease

  22338072   PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysis

  22546774   PNPLA3 gene-by-visceral adipose tissue volume interaction and the pathogenesis of fatty liver disease: the NHLBI family heart study

  22634340   Association of the IL28B genotype with insulin resistance in patients with chronic hepatitis C

  22704398   PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals

  22719876   Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese

  22863264   Genetic polymorphism in cyclooxygenase-2 promoter affects hepatic inflammation and fibrosis in patients with chronic hepatitis C

  22863562   PNPLA3 polymorphisms and liver aminotransferase levels in a Mexican American population

  22869157   The impact of patatin-like phospholipase domain-containing protein 3 polymorphism on hepatocellular carcinoma prognosis

  22878467   Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro

  22884299   PNPLA3, a genetic marker of progressive liver disease, still hiding its metabolic function?

  22898488   The I148M PNPLA3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controls

  23032985   The interaction of rs738409, obesity, and alcohol: a population-based autopsy study

  23069476   PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis

  23269818   A common variant in the peroxisome proliferator-activated receptor-γ coactivator-1α gene is associated with nonalcoholic fatty liver disease in obese children

  23275357   The association between hepatic fat content and liver injury in obese children and adolescents: effects of ethnicity, insulin resistance, and common gene variants

  23292069   Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis

  23334462   Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3

  23416328   Association between variants in or near PNPLA3, GCKR, and PPP1R3B with ultrasound-defined steatosis based on data from the third National Health and Nutrition Examination Survey

  23418085   Interactions of allelic variance of PNPLA3 with nongenetic factors in predicting nonalcoholic steatohepatitis and nonhepatic complications of severe obesity

  23512881   A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population

  23535911   Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan

  23564580   Patatin-like phospholipase domain-containing 3 I148M affects liver steatosis in patients with chronic hepatitis B

  23734760   Genetic variation in the patatin-like phospholipase domain-containing protein-3 (PNPLA-3) gene in Asian Indians with nonalcoholic fatty liver disease

  23772356   Predictive impact of polymorphism of PNPLA3 on HCC development after interferon therapy in Japanese patients with chronic hepatitis C

  23776098   Genetic variation in the PNPLA3 gene and hepatocellular carcinoma in USA: risk and prognosis prediction

  23800943   Association of glucokinase regulatory gene polymorphisms with risk and severity of non-alcoholic fatty liver disease: an interaction study with adiponutrin gene

  23815500   Oxidized fatty acids: A potential pathogenic link between fatty liver and type 2 diabetes in obese adolescents?

  23820649   Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease

  23872669   Patatin-like phospholipase domain-containing protein 3 rs738409-G in recipients of liver transplants is a risk factor for graft steatosis

  24102786   PNPLA3 I148M (rs738409) genetic variant and age at onset of at-risk alcohol consumption are independent risk factors for alcoholic cirrhosis

  24114809   Association between the PNPLA3 (rs738409 C>G) variant and hepatocellular carcinoma: Evidence from a meta-analysis of individual participant data

  24114820   Genetic factors affecting susceptibility to alcoholic liver disease in an Indian population

  24123231   Donor PNPLA3 rs738409 genotype affects fibrosis progression in liver transplantation for hepatitis C

  24125181   Impact of PNPLA3 polymorphisms on the development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection

  24333862   A population-based study on the prevalence of NASH using scores validated against liver histology

  24345846   A 4-polymorphism risk score predicts steatohepatitis in children with nonalcoholic fatty liver disease

  24369119   Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function

  24417250   PNPLA3 gene polymorphism accounts for fatty liver in community subjects without metabolic syndrome

  24425067   Reply: To PMID 24114809

  24445574   The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis

  24477042   Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals

  24498332   Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic fatty liver disease

  24563329   The PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels

  24607626   Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma

  24627307   Influence of dietary pattern, physical activity, and I148M PNPLA3 on steatosis severity in at-risk adolescents