SNP information rs659366

Research and publications:

  11381268   A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans.

  15562023   The common -866G/A polymorphism in the promoter region of the UCP-2 gene is associated with reduced risk of type 2 diabetes in Caucasians from Italy.

  16046815   Data-mining analysis suggests an epigenetic pathogenesis for type 2 diabetes

  17570749   Genetic prediction of future type 2 diabetes

  17701054   Interaction between the UCP2-866G/A, mtDNA 10398G/A and PGC1alpha p.Thr394Thr and p.Gly482Ser polymorphisms in type 2 diabetes susceptibility in North Indian population.

  17870627   Association between obesity and insulin resistance with UCP2-UCP3 gene variants in Spanish children and adolescents.

  19387457   Association of UCP2 -866 G/A polymorphism with chronic inflammatory diseases.

  19406964   Association of genetic variants with chronic kidney disease in Japanese individuals.

  19681913   Polymorphisms of the UCP2 gene are associated with proliferative diabetic retinopathy in patients with diabetes mellitus.

  19769793   Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study.

  19876010   A preliminary candidate genotype-intermediate phenotype study of satiation and gastric motor function in obesity

  20145583   Interaction between the UCP2 -866 G>A polymorphism, diabetes, and beta-blocker use among patients with acute coronary syndromes.

  20359253   Effect of the common -866G/A polymorphism of the uncoupling protein 2 gene on weight loss and body composition under sibutramine therapy in an obese Taiwanese population.

  21074158   Mitochondrial uncoupling protein (UCP2-UCP3) gene cluster variation and risk of type 2 diabetes mellitus: the Women's Genome Health Study.

  21204206   Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population

  21603268   Genetic Variance in Uncoupling Protein 2 in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional -866G>A Promoter Variant (rs659366).

  21883184   Polymorphisms of the UCP2 gene are associated with body fat distribution and risk of abdominal obesity in Spanish population.

  22216339   Further support to the uncoupling-to-survive theory: the genetic variation of human UCP genes is associated with longevity.

  22241057   Variation in the uncoupling protein 2 and 3 genes and human performance.

  22291493   A common variant in the adiponectin gene on weight loss and body composition under sibutramine therapy in obesity.

  22349573   The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes.

  22533685   Uncoupling protein 2 gene polymorphisms are associated with obesity.

  23133645   The interactive effect of SIRT1 promoter region polymorphism on type 2 diabetes susceptibility in the North Indian population.

  23639961   Uncoupling protein 2 -866G/A and uncoupling protein 3 -55C/T polymorphisms in young South African Indian coronary artery disease patients.

  24804925   Meta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variability.

  24879436   Replication of 6 obesity genes in a meta-analysis of genome-wide association studies from diverse ancestries.

  25368670   CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits.

  25396419   Investigation of variants in UCP2 in Chinese type 2 diabetes and diabetic retinopathy.

  25755013   Association of UCP-3 rs1626521 with obesity and stomach functions in humans.

  26526553   Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study.

  26648684   Update on genetics and diabetic retinopathy.

  26765095   Genetic variants within telomere-associated genes, leukocyte telomere length and the risk of acute coronary syndrome in Czech women.

  26870959   Association of PON1, P2Y12 and COX1 with Recurrent Ischemic Events in Patients with Extracranial or Intracranial Stenting.

  26951191   Shortened leukocyte telomere length in type 2 diabetes mellitus: genetic polymorphisms in mitochondrial uncoupling proteins and telomeric pathways.

  27159875   Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus.

  27301474   Major components of metabolic syndrome and nutritional intakes in different genotype of UCP2 -866G/A gene polymorphisms in patients with NAFLD.

  27615599   Interactions between UCP2 SNPs and telomere length exist in the absence of diabetes or pre-diabetes.

  27794526   Association of UCP2 -866G>A Polymorphism With Nonalcoholic Fatty Liver Disease in Patients From North-West of Iran.

  27806373   The Genetic Predisposition Score of Seven Obesity-Related Single Nucleotide Polymorphisms Is Associated with Better Metabolic Outcomes after Roux-en-Y Gastric Bypass.

  28281015   Pleiotropic effects of UCP2-UCP3 variability on leucocyte telomere length and glucose homeostasis.

  28636007   Analysis of association of gene variants with obesity traits in New Zealand European children at 6 years of age.

  28771482   Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults.

  28977211   Association of 5-HT2C (rs3813929) and UCP3 (rs1800849) gene polymorphisms with type 2 diabetes in obese women candidates for bariatric surgery.

  29786102   The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population.

  30226308   [Association of UCP2 rs659366 polymorphisms with the outcomes of patients after surgery for colorectal cancer].

  30359091   Polymorphisms in the Uncoupling Protein 2 Gene Are Associated with Diabetic Retinopathy in Han Chinese Patients with Type 2 Diabetes.

  30393491   Association of common polymorphisms in the VEGFA and SIRT1 genes with type 2 diabetes-related traits in Mexicans.

  30444569   Genetic determinants of steatosis and fibrosis progression in paediatric non-alcoholic fatty liver disease.

  30518806   Association of uncoupling protein gene polymorphisms with essential hypertension in a northeastern Han Chinese population.

  30645860   [The association of rs993609 polymorphisms of gene FTO and rs659366 polymorphisms of gene UCP2 with obesity among Arctic Russian population].

  32398726   Genetic Polymorphisms, Mediterranean Diet and Microbiota-Associated Urolithin Metabotypes can Predict Obesity in Childhood-Adolescence.

  32474746   Unleash the Association of Mitochondrial Uncoupling Protein (UCP2) Promoter Variant (G-866A; rs659366) with Obesity: Stepping from a Case-Control Study to a Meta-analysis.

  32553458   UCP2-866G/A Polymorphism is Associated with Prediabetes and Type 2 Diabetes.

  32662357   Evaluation of COMT (rs4680), CNR2 (rs2501432), CNR2 (rs2229579), UCP2 (rs659366), and IL-17 (rs763780) gene variants in synthetic cannabinoid use disorder patients.

  32858880   Increased Risk of High Body Fat and Altered Lipid Metabolism Associated to Suboptimal Consumption of Vitamin A Is Modulated by Genetic Variants rs5888 (SCARB1), rs1800629 (UCP1) and rs659366 (UCP2).

  33059806   [Association of maternal diabetes mellitus and UCP2 gene polymorphisms with congenital heart disease in offspring: a case-control study].

  33191890   UCP2 and CFH Gene Variants with Genetic Susceptibility to Schizophrenia in Turkish Population.

  33578539   Association of uncoupling protein-2 -866G/A and Ala55Val polymorphisms with susceptibility to type 2 diabetes mellitus: A meta-analysis of case-control studies.

  33579234   Association of UCP1 and UCP2 variants with diabetic retinopathy susceptibility in type-2 diabetes mellitus patients: a meta-analysis.

  33888769   Association and interaction effect of UCP2 gene polymorphisms and dietary factors with congenital heart diseases in Chinese Han population.

  33941479   -866G/A and Ins/Del polymorphisms in UCP2 gene are associated with reduced short-term weight loss in patients who underwent Roux-en-Y gastric bypass.

  34289004   Impact of KCNJ11 rs5219, UCP2 rs659366, and MTHFR rs1801133 Polymorphisms on Type 2 Diabetes: A Cross-Sectional Study.

  35629388   Role of Uncoupling Protein 2 Gene Polymorphisms on the Risk of Ischemic Stroke in a Sardinian Population.