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SNP information rs6280


Normal allele: TT

A polymorphism of the dopamine D3 receptor gene is associated with chronic schizophrenia or schizoaffective disorder.

Polymorphism rs6280 is related to topics like this:

Dopamine transporter genes

The membrane-bound protein called the dopamine transporter (DAT), also known as the...

Research and publications:

  1362221   Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.

  8225313   A study of the association between schizophrenia and the dopamine D3 receptor gene.

  8411064   Excess of homozygosity at the dopamine D3 receptor gene in schizophrenia not confirmed.

  9514583   European Multicentre Association Study of Schizophrenia: a study of the DRD2 Ser311Cys and DRD3 Ser9Gly polymorphisms.

  16380908   Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder

  16650084   Linkage with the Ser9Gly DRD3 polymorphism in essential tremor families.

  16809426   A functional variant of the dopamine D3 receptor is associated with risk and age-at-onset of essential tremor.

  16893532   Novel, replicated associations between dopamine D3 receptor gene polymorphisms and schizophrenia in two independent samples.

  17339592   DRD3 variant and risk of essential tremor.

  17466074   Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study

  17630406   Dopamine genes and schizophrenia: case closed or evidence pending?

  18320559   Dopamine receptor D3 genotype association with greater acute positive symptom remission with olanzapine therapy in predominately caucasian patients with chronic schizophrenia or schizoaffective disorder.

  18348205   A functional polymorphism, rs6280, in DRD3 is significantly associated with nicotine dependence in European-American smokers.

  18351593   DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first-episode psychosis adolescents

  18366720   Association of dopaminergic pathway gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes.

  18593715   Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation.

  18603647   Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response

  18698231   Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.

  18781856   Genetic underpinnings of tardive dyskinesia: passing the baton to pharmacogenetics.

  18821566   SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families.

  18987889   A common haplotype of DRD3 affected by recent positive selection is associated with protection from schizophrenia.

  19156168   Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.

  19197363   A genome-wide investigation of SNPs and CNVs in schizophrenia.

  19207358   Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence.

  19302829   Effects of the DRD3 Ser9Gly polymorphism on aripiprazole efficacy in schizophrenic patients as modified by clinical factors.

  19358223   The DRD3 rs6280 polymorphism and prevalence of tardive dyskinesia: a meta-analysis.

  19379518   Development of a fingerprinting panel using medically relevant polymorphisms.

  19475583   A candidate gene study of Tardive dyskinesia in the CATIE schizophrenia trial.

  19604093   Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients

  19669131   Clinical and pharmacogenetic factors determining withdrawal of non-ergoline dopamine agonists in Parkinson's disease.

  19693267   Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.

  20236178   Dopamine receptor 3 (DRD3) polymorphism and risk for migraine.

  20565774   Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project

  20732626   Family-based genome-wide association scan of attention-deficit/hyperactivity disorder.

  21083670   Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD).

  21162693   Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction.

  21491142   Dopamine receptor D3 genetic polymorphism (rs6280TC) is associated with rates of cognitive impairment in methamphetamine-dependent men with HIV: preliminary findings.

  21527290   Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood.

  21595009   Converging evidence implicates the dopamine D3 receptor gene in vulnerability to schizophrenia.

  21663922   Association of DRD2 and DRD3 polymorphisms with Parkinson's disease in a multiethnic consortium.

  21686075   The Role of Genetics in Nicotine Dependence: Mapping the Pathways from Genome to Syndrome

  21687501   Pharmacogenetics of antidepressants.

  21728034   Methamphetamine-associated psychosis.

  21738487   Genome-wide internet-based association study identifies two new loci and a significant genetic component of Parkinson's disease.

  22021758   Interaction of early environment, gender and genes of monoamine neurotransmission in the aetiology of depression in a large population-based Finnish birth cohort.

  22024213   A novel gene-environment interaction involved in endometriosis

  22105624   The genetics of attention deficit/hyperactivity disorder in adults, a review.

  22287936   Pharmacogenetics of antipsychotic treatment response and side effects.

  22569179   Rs1076560, a functional variant of the dopamine D2 receptor gene, confers risk of schizophrenia in Han Chinese.

  22615781   Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.

  22940547   Preliminary evidence for association between schizophrenia and polymorphisms in the regulatory Regions of the ADRA2A, DRD3 and SNAP-25 Genes.

  22963930   Custom genotyping for substance addiction susceptibility genes in Jordanians of Arab descent.

  23097719   Current perspectives on the neurobiology of drug addiction: a focus on genetics and factors regulating gene expression.

  23312624   Dopamine receptor D3 (DRD3) gene rs6280 variant and risk for restless legs syndrome.

  23856854   Positive effects of methylphenidate on hyperactivity are moderated by monoaminergic gene variants in children with autism spectrum disorders.

  23932573   Dopaminergic gene polymorphisms and cognitive function in a north Indian schizophrenia cohort.

  24398431   DRD3 variation associates with early-onset heroin dependence, but not specific personality traits.

  24728302   Higher prevalence of migraine in essential tremor: a case-control study.

  24776816   DRD3 gene rs6280 polymorphism may be associated with alcohol dependence overall and with Lesch type I alcohol dependence in Koreans.

  24927283   Role of nicotine dependence in the association between the dopamine receptor gene DRD3 and major depressive disorder.

  24944790   Screening for 392 polymorphisms in 141 pharmacogenes.

  24996618   Host genetic factors predisposing to HIV-associated neurocognitive disorder.

  25102390   Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain in sickle cell disease.

  25365808   Genetic basis of delay discounting in frequent gamblers: examination of a priori candidates and exploration of a panel of dopamine-related loci.

  25658328   Polymorphism in the serotonin receptor 2a (HTR2A) gene as possible predisposal factor for aggressive traits.

  25660313   Meta-analysis of six genes (BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA) involved in neuroplasticity and the risk for alcohol dependence.

  25698199   Association between Tourette syndrome and the dopamine D3 receptor gene rs6280.

  25733959   Pharmacogenetics and outcome with antipsychotic drugs.

  25819021   A review of pharmacogenetic studies of substance-related disorders.

  25896831   DRD and GRIN2B polymorphisms and their association with the development of impulse control behavior in Malaysian patients with Parkinson's disease.

  26131011   Lack of association of DRD3 and CNR1 polymorphisms with premenstrual dysphoric disorders.

  26272535   The placebo effect: From concepts to genes.

  26429319   Influence of dopamine receptor gene polymorphisms on circulating T lymphocytes: A pilot study in healthy subjects.

  26627941   Association of Parkinson disease age of onset with DRD2, DRD3 and GRIN2B polymorphisms.

  26857559   A pharmacogenetic pilot study reveals MTHFR, DRD3, and MDR1 polymorphisms as biomarker candidates for slow atorvastatin metabolizers.

  26926883   Genetic variation and dopamine D2 receptor availability: a systematic review and meta-analysis of human in vivo molecular imaging studies.

  27066308   Dopamine pathway gene variants may modulate cognitive performance in the DHS - Mind Study.

  27127627   Likelihood of mechanistic roles for dopaminergic, serotonergic and glutamatergic receptors in tardive dyskinesia: A comparison of genetic variants in two independent patient populations.

  27166759   Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.

  27325396   The Ser9Gly variant of the dopamine D3 receptor is associated with impulse control disorders in patients with Parkinson's disease.

  27375535   Molecular Signatures of Natural Selection for Polymorphic Genes of the Human Dopaminergic and Serotonergic Systems: A Review.

  27456607   A family study of DRD3 rs6280, SLC1A2 rs3794087 and MAPT rs1052553 variants in essential tremor.

  27497990   Polymorphisms of dopamine receptor genes and the risk of visual hallucinations in patients with Parkinson's disease.

  27647283   Dopamine Receptor Genes Modulate Associative Memory in Old Age.

  27757066   Pharmacogenetic tests for antipsychotic medications: clinical implications and considerations.

  27779245   Association between DRD2 and DRD3 gene polymorphisms and gastrointestinal symptoms induced by levodopa therapy in Parkinson's disease.

  27784028   Investigating the Genetic Basis of Social Conformity: The Role of the Dopamine Receptor 3 (DRD3) Gene.

  27853387   Treatment-resistant schizophrenia: current insights on the pharmacogenomics of antipsychotics.

  27895608   Genetic Consideration of Schizotypal Traits: A Review.

  28028606   Novelty seeking mediates the effect of DRD3 variation on onset age of amphetamine dependence in Han Chinese population.

  28451935   Single nucleotide polymorphisms in genes of dopaminergic pathways are associated with bruxism.

  28470827   Pharmacogenomics and Efficacy of Risperidone Long-Term Treatment in Thai Autistic Children and Adolescents.

  28696411   Combined study of genetic and epigenetic biomarker risperidone treatment efficacy in Chinese Han schizophrenia patients.

  28777361   [Associations between chronotype, road accidents and polymorphisms in genes linked with biological clock and dopaminergic system].

  28927418   A systematic review and integrative approach to decipher the overall molecular link between levodopa response and Parkinson's disease.

  28940477   cAMP levels in lymphocytes and CD4(+) regulatory T-cell functions are affected by dopamine receptor gene polymorphisms.

  29135816   Dopaminergic Genetic Variants and Voluntary Externally Paced Exercise Behavior.

  29200860   No association between dopamine D3 receptor gene Ser9Gly polymorphism (rs6280) and risk of schizophrenia: an updated meta-analysis.

  29249220   DRD3 Ser9Gly Polymorphism and Its Influence on Risperidone Response in Autistic Children.

  29255361   Potential link between genetic polymorphisms of catechol-O-methyltransferase and dopamine receptors and treatment efficacy of risperidone on schizophrenia.

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