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SNP information rs4961

Normal allele: GG

The ADD1 gene variant is associated with the progression of blood pressure and the occurrence of hypertension. The risk of arterial hypertension is increased by 1.8 times. Increased sensitivity of blood pressure to salt, good response to salt-restricted diet.

Polymorphism rs4961 is related to topics like this:

Abnormally high blood pressure in the arteries, which transport blood from the heart to the rest of...


Research and publications:

  9149697   Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension.

  9607177   Alpha-adducin polymorphisms and renal sodium handling in essential hypertensive patients.

  10024330   Adducin polymorphism affects renal proximal tubule reabsorption in hypertension.

  16595073   Functional nsSNPs from carcinogenesis-related genes expressed in breast tissue: potential breast cancer risk alleles and their distribution across human populations

  18279468   Ten renin-angiotensin system-related gene polymorphisms in maximally treated Canadian Caucasian patients with heart failure.

  18398333   Relationships among endogenous ouabain, alpha-adducin polymorphisms and renal sodium handling in primary hypertension.

  18513389   New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background

  18660489   Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.

  18787518   Arterial properties in relation to genetic variations in the adducin subunits in a white population.

  19131662   A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients

  19199261   [Association of the polymorphisms of sodium transport related genes with essential hypertension].

  19263529   Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach

  19379518   Development of a fingerprinting panel using medically relevant polymorphisms.

  19559392   A candidate gene association study of 77 polymorphisms in migraine

  19574959   Novel genetic variants in the alpha-adducin and guanine nucleotide binding protein beta-polypeptide 3 genes and salt sensitivity of blood pressure.

  19838659   alpha- and beta-Adducin polymorphisms affect podocyte proteins and proteinuria in rodents and decline of renal function in human IgA nephropathy.

  19927152   Accumulation of common polymorphisms is associated with development of hypertension: a 12-year follow-up from the Ohasama study.

  19960031   Lack of association between alpha-adducin G460W polymorphism and hypertension: evidence from a case-control study and a meta-analysis.

  20145305   Association between alpha-adducin gene polymorphism (Gly460Trp) and genetic predisposition to salt sensitivity: a meta-analysis.

  20565774   Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project

  20577119   Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study.

  20981351   Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study.

  21058046   Genetics of salt-sensitive hypertension.

  21194526   A study of ACE and ADD1 polymorphism in ischemic and hemorrhagic stroke.

  21291465   The association of genetic polymorphisms with cerebral palsy: a meta-analysis.

  21467728   Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study.

  21692745   Identification of diuretic non-responders with poor long-term clinical outcomes: a 1-year follow-up of 176 non-azotaemic cirrhotic patients with moderate ascites.

  22024213   A novel gene-environment interaction involved in endometriosis

  22198647   Do ACE (rs4646994) and αADDUCIN (rs4961) gene polymorphisms predict the recurrence of hypertensive intracerebral hemorrhage?

  22810272   Computational study of ADD1 gene polymorphism associated with hypertension.

  22992668   Pharmacogenomics knowledge for personalized medicine.

  23133444   Genetic variation in CYP17A1 is associated with arterial stiffness in diabetic subjects.

  25567773   The interactions between alcohol consumption and DNA methylation of the ADD1 gene promoter modulate essential hypertension susceptibility in a population-based, case-control study.

  25803781   Exome analysis reveals differentially mutated gene signatures of stage, grade and subtype in breast cancers.

  25869180   Habitual dietary intake of β-carotene, vitamin C, folate, or vitamin E may interact with single nucleotide polymorphisms on brachial-ankle pulse wave velocity in healthy adults.

  26335431   Altered erythrocyte membrane protein composition mirrors pleiotropic effects of hypertension susceptibility genes and disease pathogenesis.

  26387843   Gene and dietary calcium interaction effects on brachial-ankle pulse wave velocity.

  26444257   Genetic diversity of variants involved in drug response and metabolism in Sri Lankan populations: implications for clinical implementation of pharmacogenomics.

  27029813   Multivariate models from RNA-Seq SNVs yield candidate molecular targets for biomarker discovery: SNV-DA.

  27480094   Association of interactions between dietary salt consumption and hypertension-susceptibility genetic polymorphisms with blood pressure among Japanese male workers.

  27616475   Gene variants as risk factors for gastroschisis.

  27940662   Deep-targeted exon sequencing reveals renal polymorphisms associate with postexercise hypotension among African Americans.

  28872890   Synergistic Association of Genetic Variants with Environmental Risk Factors in Susceptibility to Essential Hypertension.

  29550988   Genetic variants conferring susceptibility to gastroschisis: a phenomenon restricted to the interaction with the environment?

  30387422   [Genetic Polymorphisms Associated with the Onset of Arterial Hypertension in a Portuguese Population].

  30552709   Association between α-adducin rs4961 polymorphism and hypertension: A meta-analysis based on 40 432 subjects.

  31760884   Hypertension in High School Students: Genetic and Environmental Factors: The HYGEF Study.

  31943323   Letter to the editor: Association between α-adducin rs4961 polymorphism and hypertension: A meta-analysis based on 40 432 subjects.

  32936528   Important Pharmacogenetic Information for Drugs Prescribed During the SARS-CoV-2 Infection (COVID-19).

  35866398   A Machine Learning Model Based on Genetic and Traditional Cardiovascular Risk Factors to Predict Premature Coronary Artery Disease.

  36035164   ADD1 Single Nucleotide Polymorphisms Are Associated With Essential Hypertension Among Han and Mongolian Population in Inner Mongolia Area.

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