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SNP information rs4588

Normal allele: CC

Associated with lower vitamin D levels and therefore potential vitamin D deficiency. Increases vitamin D deficiency among pregnant women and the likelihood of gestational diabetes.

Polymorphism rs4588 is related to topics like this:

Genetic vitamin D deficiency

Vitamin D plays a vital role in maintaining musculoskeletal health. Recent studies have linked...


Research and publications:

  1352271   Molecular analysis of the gene for the human vitamin-D-binding protein (group-specific component): allelic differences of the common genetic GC types.

  15726497   Gene-environment interaction effects on the development of immune responses in the 1st year of life

  15817713   Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations

  17054776   The genetics of chronic obstructive pulmonary disease

  17244366   Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study

  18559548   The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status.

  18593774   Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans

  19116321   Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women.

  19131662   A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients

  19263529   Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach

  19488670   Vitamin D binding protein genotype and osteoporosis.

  19559392   A candidate gene association study of 77 polymorphisms in migraine

  19951401   Chronic obstructive pulmonary disease: towards pharmacogenetics

  19996341   Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene.

  20007432   Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosis

  20086113   Genetic variation in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer: results from the Colon Cancer Family Registry

  20363324   A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations.

  20541252   Common genetic determinants of vitamin D insufficiency: a genome-wide association study.

  20812960   Vitamin D-binding protein polymorphisms are not associated with development of (multiple) basal cell carcinomas.

  21357399   Vitamin D receptor (VDR) and group-specific component (GC, vitamin D-binding protein) polymorphisms in myopia

  21430387   Nutrigenomics, vitamin D and cancer prevention

  21441443   Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes

  21810276   Vitamin D binding protein variants associate with asthma susceptibility in the Chinese Han population.

  21844098   Reduced serum vitamin D-binding protein levels are associated with type 1 diabetes.

  21972121   Associations between common variants in GC and DHCR7/NADSYN1 and vitamin D concentration in Chinese Hans.

  22022476   Common genetic variants are associated with accelerated bone mineral density loss after hematopoietic cell transplantation.

  22129377   Nutrigenomics and personalized diets: What will they mean for food?

  22144504   Polymorphic variation in the GC and CASR genes and associations with vitamin D metabolite concentration and metachronous colorectal neoplasia.

  22205958   Common variation in vitamin D pathway genes predicts circulating 25-hydroxyvitamin D Levels among African Americans.

  22583563   Genetic and environmental predictors of serum 25-hydroxyvitamin D concentrations among middle-aged and elderly Chinese in Singapore.

  22610885   Vitamin D binding protein gene polymorphisms and baseline vitamin D levels as predictors of antiviral response in chronic hepatitis C.

  22629401   Evaluation of genetic markers as instruments for Mendelian randomization studies on vitamin D.

  22769019   Association of inflammatory gene polymorphisms with ischemic stroke in a Chinese Han population.

  23070913   Association of vitamin D binding protein polymorphism with long-term kidney allograft survival in Hispanic kidney transplant recipients.

  23169318   Genetic sequence variants in vitamin D metabolism pathway genes, serum vitamin D level and outcome in head and neck cancer patients.

  23185470   Vitamin D in a northern Canadian first nation population: dietary intake, serum concentrations and functional gene polymorphisms.

  23191998   Genetic variations in the vitamin D binding protein and season-specific levels of vitamin D among older adults.

  23427793   Common variants of the vitamin D binding protein gene and adverse health outcomes.

  23456391   Serum vitamin D metabolites in colorectal cancer patients receiving cholecalciferol supplementation: correlation with polymorphisms in the vitamin D genes.

  23505139   An analysis of the association between the vitamin D pathway and serum 25-hydroxyvitamin D levels in a healthy Chinese population.

  24200978   Serum 25(OH)D and vitamin D status in relation to VDR, GC and CYP2R1 variants in Chinese.

  24447085   Vitamin D-binding protein haplotype is associated with hospitalization for RSV bronchiolitis.

  24472850   Associations between vitamin D-binding protein isotypes, circulating 25(OH)D levels, and vitamin D metabolite uptake in colon cancer cells.

  24516573   Vitamin D levels vary during antiviral treatment but are unable to predict treatment outcome in HCV genotype 1 infected patients.

  24735339   Association of group component genetic variations in COPD and COPD exacerbation in a Japanese population.

  24768180   Vitamin-D pathway genes and HIV-1 disease progression in injection drug users.

  24868205   Vitamin D Binding Protein Impact on 25-Hydroxyvitamin D Levels under Different Physiologic and Pathologic Conditions.

  24934498   Real-life use of vitamin D3-fortified bread and milk during a winter season: the effects of CYP2R1 and GC genes on 25-hydroxyvitamin D concentrations in Danish families, the VitmaD study.

  25046415   The functional polymorphisms of VDR, GC and CYP2R1 are involved in the pathogenesis of autoimmune thyroid diseases.

  25211176   Determinants of vitamin D status in Caucasian adults: influence of sun exposure, dietary intake, sociodemographic, lifestyle, anthropometric, and genetic factors.

  25234352   Genetic and environmental influences on plasma vitamin D binding protein concentrations.

  25281353   Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study.

  25488826   Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: a nested case-control study.

  25527766   Common variants in CYP2R1 and GC genes are both determinants of serum 25-hydroxyvitamin D concentrations after UVB irradiation and after consumption of vitamin D₃-fortified bread and milk during winter in Denmark.

  25652210   Vitamin D binding protein genotype is associated with plasma 25OHD concentration in West African children.

  25920689   The associations of 25-hydroxyvitamin D levels, vitamin D binding protein gene polymorphisms, and race with risk of incident fracture-related hospitalization: Twenty-year follow-up in a bi-ethnic cohort (the ARIC Study).

  25926504   Race, vitamin D-binding protein gene polymorphisms, 25-hydroxyvitamin D, and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) Study.

  25941991   25-hydroxyvitamin D levels, vitamin D binding protein gene polymorphisms and incident coronary heart disease among whites and blacks: The ARIC study.

  25962507   Vitamin D, vitamin D binding protein gene polymorphisms, race and risk of incident stroke: the Atherosclerosis Risk in Communities (ARIC) study.

  25993607   Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.

  26067474   Association of vitamin D binding protein polymorphisms with bronchopulmonary dysplasia: a case-control study of gc globulin and bronchopulmonary dysplasia.

  26073892   Selected vitamin D metabolic gene variants and risk for autism spectrum disorder in the CHARGE Study.

  26193879   Genotype-independent association between profound vitamin D deficiency and delayed sputum smear conversion in pulmonary tuberculosis.

  26317560   Bioavailable Vitamin D in Obese Children: The Role of Insulin Resistance.

  26356094   Critically Ill Children Have Low Vitamin D-Binding Protein, Influencing Bioavailability of Vitamin D.

  26364161   Meta-analysis of vitamin D-binding protein and cancer risk.

  26380769   Vitamin D binding protein gene polymorphisms and chronic obstructive pulmonary disease: a meta-analysis.

  26383826   Association of rs7041 and rs4588 Polymorphisms of the Vitamin D Binding Protein and the rs10741657 Polymorphism of CYP2R1 with Vitamin D Status Among Jordanian Patients.

  26404398   Hypovitaminosis D in a Young Lebanese Population: Effect of GC Gene Polymorphisms on Vitamin D and Vitamin D Binding Protein Levels.

  26417870   Potential causal associations between vitamin D and uric acid: Bidirectional mediation analysis.

  26446360   Mendelian randomization studies of biomarkers and type 2 diabetes.

  26458880   High prevalence of vitamin D deficiency among women of child-bearing age in Lahore Pakistan, associating with lack of sun exposure and illiteracy.

  26497592   The rs1803274 polymorphism of the BCHE gene is associated with an increased risk of coronary in-stent restenosis.

  26872154   Low Vitamin-D Levels Combined with PKP3-SIGIRR-TMEM16J Host Variants Is Associated with Tuberculosis and Death in HIV-Infected and -Exposed Infants.

  26881316   Independent associations of polymorphisms in vitamin D binding protein (GC) and vitamin D receptor (VDR) genes with obesity and plasma 25OHD3 levels demonstrate sex dimorphism.

  26893716   Polymorphic variants in the vitamin D pathway genes and the risk of ovarian cancer among non-carriers of BRCA1/BRCA2 mutations.

  26962819   GC Gene Polymorphism and Unbound Serum Retinol-Binding Protein 4 Are Related to the Risk of Insulin Resistance in Patients With Chronic Hepatitis C: A Prospective Cross-Sectional Study.

  27116295   Serum Bioavailable Vitamin D Concentrations and Bone Mineral Density in Women After Obesity Surgery.

  27154872   Vitamin D status in primary hyperparathyroidism: effect of genetic background.

  27160686   Vitamin D deficiency associates with susceptibility to tuberculosis in Pakistan, but polymorphisms in VDR, DBP and CYP2R1 do not.

  27570856   Genetic influence on circulating vitamin D among Saudi Arabians.

  27625044   Genetically Low Vitamin D Levels, Bone Mineral Density, and Bone Metabolism Markers: a Mendelian Randomisation Study.

  27669215   Vitamin D-Related Gene Polymorphisms, Plasma 25-Hydroxy-Vitamin D, Cigarette Smoke and Non-Small Cell Lung Cancer (NSCLC) Risk.

  27736940   Vitamin D Receptor Gene Polymorphism and the Risk of Colorectal Cancer: A Nested Case-Control Study.

  27768857   Effects of Genetic and Nongenetic Factors on Total and Bioavailable 25(OH)D Responses to Vitamin D Supplementation.

  27919752   Bioavailable 25(OH)D but Not Total 25(OH)D Is an Independent Determinant for Bone Mineral Density in Chinese Postmenopausal Women.

  28008453   Association of VDBP and CYP2R1 gene polymorphisms with vitamin D status in women with polycystic ovarian syndrome: a north Indian study.

  28061456   Vitamin D receptor polymorphisms or serum levels as key drivers of breast cancer development? The question of the vitamin D pathway.

  28079136   SNP rs11185644 of RXRA gene is identified for dose-response variability to vitamin D3 supplementation: a randomized clinical trial.

  28278285   Genetic variant in vitamin D-binding protein is associated with metabolic syndrome and lower 25-hydroxyvitamin D levels in polycystic ovary syndrome: A cross-sectional study.

  28284354   Vitamin D-binding protein gene polymorphisms are not associated with MS risk in an Italian cohort.

  28296915   Genetic variation in the vitamin D pathway CYP2R1 gene predicts sustained HBeAg seroconversion in chronic hepatitis B patients treated with pegylated interferon: A multicenter study.

  28382877   Common genetic variants are associated with lower serum 25-hydroxyvitamin D concentrations across the year among children at northern latitudes.

  28415985   Vitamin D-related gene polymorphism predict treatment response to pegylated interferon-based therapy in Thai chronic hepatitis C patients.

  28590769   Associations of Genetic Polymorphisms Relevant to Metabolic Pathway of Vitamin D3 with Development and Prognosis of Childhood Bronchial Asthma.

  28779988   Impact of polymorphism rs7041 and rs4588 of Vitamin D Binding Protein on the extent of coronary artery disease.

  28809744   Effect of Vitamin D Serum Levels and GC Gene Polymorphisms in Liver Fibrosis Due to Chronic Hepatitis C.

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