Normal allele: CC
A functional variant of the microRNA-146a promoter modulates its expression and increases the risk of systemic lupus erythematosus.
Polymorphism rs2431697 is related to topics like this:
Research and publications:
19440199 Recent insights into the genetic basis of systemic lupus erythematosus.
20953187 Association analyses identify six new psoriasis susceptibility loci in the Chinese population.
21068098 Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus.
24803388 Association of miR-146a polymorphisms with systemic lupus erythematosus: a meta-analysis.
24991086 Novel insights into miRNA in lung and heart inflammatory diseases.
25008481 Prognostic role of MIR146A polymorphisms for cardiovascular events in atrial fibrillation.
25034154 Clinical perspectives on lupus genetics: advances and opportunities.
26366721 Common MIR146A Polymorphisms in Chinese Ankylosing Spondylitis Subjects and Controls.
27906046 Chromatin landscapes and genetic risk in systemic lupus.
28470127 Polymorphisms associated with etanercept response in moderate-to-severe plaque psoriasis.
29902229 miR-146a deficiency in hematopoietic cells is not involved in the development of atherosclerosis.
31235484 Association of microRNAs genes polymorphisms with arthritis: a systematic review and meta-analysis.
32586906 miR-146a is a pivotal regulator of neutrophil extracellular trap formation promoting thrombosis.
34060972 Genetic variant in microRNA-146a gene is associated with risk of rheumatoid arthritis.