SNP information rs2273697

Research and publications:

  15821043   Variable expression of MRP2 (ABCC2) in human placenta: influence of gestational age and cellular differentiation.

  16385451   A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

  18176959   Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump.

  18395921   Role of ABCC2 common variants in intrahepatic cholestasis of pregnancy.

  18547414   Genotyping panel for assessing response to cancer chemotherapy

  18817904   Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: effects on population-based association studies.

  19568750   MRP2 and GSTP1 polymorphisms and chemotherapy response in advanced non-small cell lung cancer.

  20216337   A nonsynonymous variation in MRP2/ABCC2 is associated with neurological adverse drug reactions of carbamazepine in patients with epilepsy.

  21072184   Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition.

  21288825   Association of pharmacogenetic markers with premature discontinuation of first-line anti-HIV therapy: an observational cohort study.

  21434840   The influence of pharmacogenetics and cofactors on clinical outcomes in kidney transplantation.

  21541183   Urinary elimination of coproporphyrins is dependent on ABCC2 polymorphisms and represents a potential biomarker of MRP2 activity in humans.

  21628669   Genetic variants of ABCC10, a novel tenofovir transporter, are associated with kidney tubular dysfunction.

  21712189   Analysis of pharmacogenetic traits in two distinct South African populations.

  21738081   PharmGKB summary: carbamazepine pathway.

  22112610   Common variants in ABCB1, ABCC2 and ABCG2 genes and clinical outcomes among women with advanced stage ovarian cancer treated with platinum and taxane-based chemotherapy: a Gynecologic Oncology Group study.

  22318656   Interindividual variability in hepatic expression of the multidrug resistance-associated protein 2 (MRP2/ABCC2): quantification by liquid chromatography/tandem mass spectrometry.

  22630058   ABCC2 polymorphisms and haplotype are associated with drug resistance in Chinese epileptic patients.

  23052037   Polymorphisms in genes encoding potential mercury transporters and urine mercury concentrations in populations exposed to mercury vapor from gold mining.

  23056078   Gene polymorphisms of ABC transporters are associated with clinical outcomes in children with acute lymphoblastic leukemia.

  23069858   Impact of ABCC2 polymorphisms on high-dose methotrexate pharmacokinetics in patients with lymphoid malignancy.

  23252947   Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy.

  23443032   Fetal polymorphisms at the ABCB1-transporter gene locus are associated with susceptibility to non-syndromic oral cleft malformations.

  23506516   A systematic review and meta-analysis of the role of ABCC2 variants on drug response in patients with epilepsy.

  23633119   Multidrug resistance-associated protein 2 (MRP2/ABCC2) haplotypes significantly affect the pharmacokinetics of tacrolimus in kidney transplant recipients.

  23717663   Linkage disequilibrium between polymorphisms of ABCB1 and ABCC2 to predict the treatment outcome of Malaysians with complex partial seizures on treatment with carbamazepine mono-therapy at the Kuala Lumpur Hospital.

  23766564   Pharmacogenetics of chronic pain and its treatment.

  23876492   Clinical and pharmacogenetic predictors of circulating atorvastatin and rosuvastatin concentrations in routine clinical care.

  23896815   Influence of ATP-binding cassette polymorphisms on neurological outcome after traumatic brain injury.

  23940561   Polymorphism of ORM1 is associated with the pharmacokinetics of telmisartan.

  24557078   Genomewide association study of atazanavir pharmacokinetics and hyperbilirubinemia in AIDS Clinical Trials Group protocol A5202.

  24732756   Selected ABCB1, ABCB4 and ABCC2 polymorphisms do not enhance the risk of drug-induced hepatotoxicity in a Spanish cohort.

  24831289   Polymorphisms in ABC transporter genes and concentrations of mercury in newborns--evidence from two Mediterranean birth cohorts.

  24889212   Systematic review: interactions between aspirin, and other nonsteroidal anti-inflammatory drugs, and polymorphisms in relation to colorectal cancer.

  24944790   Screening for 392 polymorphisms in 141 pharmacogenes.

  24991206   Polymorphisms in folate pathway and pemetrexed treatment outcome in patients with malignant pleural mesothelioma.

  25110414   Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years.

  25132748   FOLFOX/FOLFIRI pharmacogenetics: the call for a personalized approach in colorectal cancer therapy.

  25155932   ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children.

  25346718   MDR-1 and MRP2 Gene Polymorphisms in Mexican Epileptic Pediatric Patients with Complex Partial Seizures.

  25348619   Influence of single-nucleotide polymorphisms on deferasirox C trough levels and effectiveness.

  25426075   The role of drug transporters in the kidney: lessons from tenofovir.

  25491747   Interactions between meat intake and genetic variation in relation to colorectal cancer.

  25554586   Report of new haplotype for ABCC2 gene: rs17222723 and rs8187718 in cis.

  25741868   Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

  25881102   Genetic variability in drug transport, metabolism or DNA repair affecting toxicity of chemotherapy in ovarian cancer.

  26287941   Polymorphisms associated with renal adverse effects of antiretroviral therapy in a Southern Brazilian HIV cohort.

  26369774   Impact of New Genomic Technologies on Understanding Adverse Drug Reactions.

  26743341   Impact of Polymorphic Variations of Gemcitabine Metabolism, DNA Damage Repair, and Drug-Resistance Genes on the Effect of High-Dose Chemotherapy for Relapsed or Refractory Lymphoid Malignancies.

  26785747   Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan.

  26807589   A Single-Nucleotide Polymorphism in ABCC4 Is Associated with Tenofovir-Related Beta2-Microglobulinuria in Thai Patients with HIV-1 Infection.

  26858644   Cross-Comparison of Exome Analysis, Next-Generation Sequencing of Amplicons, and the iPLEX(®) ADME PGx Panel for Pharmacogenomic Profiling.

  27110117   Clinically relevant genetic variants of drug-metabolizing enzyme and transporter genes detected in Thai children and adolescents with autism spectrum disorder.

  27437086   Allele Frequencies of the Single Nucleotide Polymorphisms Related to the Body Burden of Heavy Metals in the Korean Population and Their Ethnic Differences.

  27590272   Associations of genetic polymorphisms of the transporters organic cation transporter 2 (OCT2), multidrug and toxin extrusion 1 (MATE1), and ATP-binding cassette subfamily C member 2 (ABCC2) with platinum-based chemotherapy response and toxicity

  27610747   Specific OCT1 and ABCG2 polymorphisms are associated with Lamotrigine concentrations in Chinese patients with epilepsy.

  27825374   Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters.

  27855531   ABCC2 (1249G > A) polymorphism implicates altered transport activity for sorafenib.

  27855565   Impact of histamine receptors H1 and H3 polymorphisms on antipsychotic-induced weight gain.

  27886333   Association between the polymorphisms in the ATP-binding cassette genes ABCB1 and ABCC2 and the risk of drug-resistant epilepsy in a Chinese Han population.

  28353455   Pharmacogenomic influence on sepsis outcome in critically ill patients.

  28422153   Clinical-pharmacogenetic models for personalized cancer treatment: application to malignant mesothelioma.

  28572465   Relationship Between Polymorphisms in Methotrexate Pathway Genes and Outcome of Methotrexate Treatment in a Cohort of 119 Patients with Juvenile Idiopathic Arthritis.

  28640195   Pharmacogenomic Variants May Influence the Urinary Excretion of Novel Kidney Injury Biomarkers in Patients Receiving Cisplatin.

  28837897   Effects of ABCB1, ABCC2, UGT2B7 and HNF4α genetic polymorphisms on oxcarbazepine concentrations and therapeutic efficacy in patients with epilepsy.

  29151102   The Effect of Genistein Supplementation on Vitamin D Levels and Bone Turnover Markers during the Summer in Healthy Postmenopausal Women: Role of Genotypes of Isoflavone Metabolism.

  29193749   Clinical Implementation of Pharmacogenetic Testing in a Hospital of the Spanish National Health System: Strategy and Experience Over 3 Years.

  29681089   Genetic variation in biotransformation enzymes, air pollution exposures, and risk of spina bifida.

  29724294   ABCC2 rs2273697 is associated with valproic acid concentrations in patients with epilepsy on valproic acid monotherapy.

  29873816   Effect of ABCC2 and ABCG2 Gene Polymorphisms and CSF-to-Serum Albumin Ratio on Ceftriaxone Plasma and Cerebrospinal Fluid Concentrations.

  30018187   New ABCC2 rs3740066 and rs2273697 Polymorphisms Identified in a Healthy Colombian Cohort.

  30215770   Pharmacokinetics and pharmacogenomics of mycophenolic acid and its clinical correlations in maintenance immunosuppression for lupus nephritis.

  30237583   An exploratory study by DMET array identifies a germline signature associated with imatinib response in gastrointestinal stromal tumor.

  30896644   Comparison of oxcarbazepine efficacy and MHD concentrations relative to age and BMI: Associations among ABCB1, ABCC2, UGT2B7, and SCN2A polymorphisms.

  31086207   Implications of genetic variation of common Drug Metabolizing Enzymes and ABC Transporters among the Pakistani Population.

  31137904   Inter-Individual Variability in Xenobiotic-Metabolizing Enzymes: Implications for Human Aging and Longevity.

  31195293   Polymorphisms in potential mercury transporter ABCC2 and neurotoxic symptoms in populations exposed to mercury vapor from goldmining.

  31354331   Effects of MTHFR and ABCC2 gene polymorphisms on antiepileptic drug responsiveness in Jordanian epileptic patients.

  31391850   Role of Four ABC Transporter Genes in Pharmacogenetic Susceptibility to Breast Cancer in Jordanian Patients.

  31573470   Is the T-G-CT-G SNRNP70 haplotype another proof that mixed connective tissue disease is distinct from systemic lupus erythematosus and systemic sclerosis? A novel gene variant in SNRNP70 gene.

  32872162   Pharmacogenomics to Predict Tumor Therapy Response: A Focus on ATP-Binding Cassette Transporters and Cytochromes P450.

  32930952   Effect of Genetic Polymorphisms on the Pharmacokinetics of Deferasirox in Healthy Chinese Subjects and an Artificial Neural Networks Model for Pharmacokinetic Prediction.

  33291741   Pharmacogenetic Study of Trabectedin-Induced Severe Hepatotoxicity in Patients with Advanced Soft Tissue Sarcoma.

  33323685   The association of transporter ABCC2 (MRP2) genetic variation and drug-induced hyperbilirubinemia.

  33519226   Genetic Diversity of Drug-Related Genes in Native Americans of the Brazilian Amazon.

  33569925   Gene-environment interactions between air pollution and biotransformation enzymes and risk of birth defects.

  33688237   Whole-Exome Sequencing in Patients Affected by Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Reveals New Variants Potentially Contributing to the Phenotype.

  33794950   Single nucleotide polymorphisms associated with methotrexate-induced nausea in juvenile idiopathic arthritis.

  34087576   A systematic review and meta-analysis of the association of ABCC2/ABCG2 polymorphisms with antiepileptic drug responses in epileptic patients.

  34169529   Association of ABCC2 Haplotypes to Mycophenolic Acid Pharmacokinetics in Stable Kidney Transplant Recipients.

  34703277   Pharmacokinetics of Tenofovir Alafenamide Fumarate and Tenofovir in the Chinese People: Effects of Non-Genetic Factors and Genetic Variations.

  35455734   Pharmacogenetic Profiling in High-Risk Soft Tissue Sarcomas Treated with Neoadjuvant Chemotherapy.