SNP information rs13361189

Research and publications:

  18438406   Genetic determinants of ulcerative colitis include the ECM1 locus and five loci involved in Crohn's disease.

  18580884   Confirmation of the association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort.

  19140132   Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.

  19165925   Deletion polymorphisms upstream of IRGM are associated with altered IRGM expression and Crohn's disease.

  19491842   Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach.

  19750224   Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains.

  19953089   Differences in genetic background between active smokers, passive smokers, and nonsmokers with Crohn's disease.

  20106866   Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease.

  20177049   Insufficient evidence for association of NOD2/CARD15 or other inflammatory bowel disease-associated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantation.

  20228799   Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

  20395867   Do Crohn's disease-associated autophagy genes ATG16L1 and IRGM play a role in granuloma formation?

  20886065   Molecular reclassification of Crohn's disease by cluster analysis of genetic variants.

  21049557   NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients.

  21079743   Interaction of Crohn's disease susceptibility genes in an Australian pediatric cohort.

  21304977   An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.

  21333900   The role of genetics in IBS

  21548950   Evaluation of 22 genetic variants with risk for Crohn's disease in an Ashkenazi Jewish population: a case-control study.

  21730793   The influence of risk alleles for Crohn's disease and smoking on the location of the disease.

  21734790   NOD2 and ATG16L1 polymorphisms influence monocyte response in Crohn's disease.

  21830272   Different and overlapping genetic loci in Crohn's disease and ulcerative colitis: correlation with pathogenesis.

  21936032   Digesting the genetics of inflammatory bowel disease: insights from studies of autophagy risk genes.

  21978003   Autophagy modulates the Mycobacterium tuberculosis-induced cytokine response.

  22065112   JAK2 rs10758669 variant in Crohn's disease: alteration of the intestinal barrier as one of the mechanisms of action.

  22573572   Phenotype-genotype profiles in Crohn's disease predicted by genetic markers in autophagy-related genes (GOIA II study).

  22713085   IRGM gene polymorphisms and risk of gastric cancer.

  23300620   Genotype/phenotype analysis of 53 genetic polymorphisms associated with Crohn's disease.

  23365659   IRGM variants and susceptibility to inflammatory bowel disease in the German population.

  23844243   GStream: improving SNP and CNV coverage on genome-wide association studies.

  24264476   Autophagy gene polymorphism is associated with susceptibility to leprosy by affecting inflammatory cytokines.

  24627602   ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes from patients with Crohn's disease.

  24859836   Functional IRGM polymorphism is associated with language impairment in glioma and upregulates cytokine expressions.

  24956270   Large-scale East-Asian eQTL mapping reveals novel candidate genes for LD mapping and the genomic landscape of transcriptional effects of sequence variants.

  25009628   IRGM rs13361189 polymorphism may contribute to susceptibility to Crohn's disease: a meta-analysis.

  25191865   Association of IRGM gene mutations with inflammatory bowel disease in the Indian population.

  25369137   A multilocus genetic study in a cohort of Italian SLE patients confirms the association with STAT4 gene and describes a new association with HCP5 gene.

  25664588   Autophagy in Helicobacter pylori Infection and Related Gastric Cancer.

  25944217   Genetic Polymorphisms in Autophagy-Associated Genes in Korean Children With Early-Onset Crohn Disease.

  26066377   Autophagy and inflammatory bowel disease: association between variants in the autophagy-related gene IRGM and susceptibility to Crohn's disease.

  26993061   Accounting for selection and correlation in the analysis of two-stage genome-wide association studies.

  27306066   Genetic Association Analysis Reveals Differences in the Contribution of NOD2 Variants to the Clinical Phenotypes of Orofacial Granulomatosis.

  27417217   Variants in the autophagy-related gene IRGM confer susceptibility to non-alcoholic fatty liver disease by modulating lipophagy.

  28983640   A haplotypic variant at the IRGM locus and rs11747270 are related to the susceptibility for chronic periodontitis.

  29228965   Genetic polymorphism in ATG16L1 gene is associated with adalimumab use in inflammatory bowel disease.

  29434451   Impaired bioactivity of granulocyte-macrophage colony-stimulating factor accelerates surgical relapse in Crohn's disease of the ileum.

  29788077   IRGM gene variants alter the relationship between visceral adipose tissue and NAFLD in patients with Crohn's disease.

  29992164   Polymorphisms in Autophagy-Related Gene IRGM Are Associated with Susceptibility to Autoimmune Thyroid Diseases.

  30335469   IRGM Crohn's disease risk alleles are associated with altered gene expression in human tissues.

  30568945   Genetic associations of inflammatory bowel disease in a South Asian population.

  30597691   The immunity-related GTPase M rs13361189 variant does not increase the risk for prevalent or incident steatosis; results from the Framingham Heart Study.

  31714311   Clinical and genetic factors influence the time to surgical recurrence after ileocolectomy for Crohn's disease.

  32045400   Clinical and genetic factors associated with complications after Crohn's ileocolectomy.

  33147747   Pathogenic Single Nucleotide Polymorphisms on Autophagy-Related Genes.

  34407136   Differential prevalence of pathobionts and host gene polymorphisms in chronic inflammatory bowel diseases: Crohn's disease and intestinal tuberculosis.

  35349414   Fever in systemic lupus erythematosus: associated clinical features and genetic factors.

  35699756   Immunity-related GTPase IRGM at the intersection of autophagy, inflammation, and tumorigenesis.