Normal allele: GG
Has been associated with serum vitamin D concentrations in several studies. The T risk allele is associated with greater reductions in insulin and HOMA-IR levels in response to a high-protein diet.
Polymorphism rs12785878 is related to topics like this:
Research and publications:
20541252 Common genetic determinants of vitamin D insufficiency: a genome-wide association study.
22112344 Seasonal variation in 25-hydroxyvitamin D concentrations in the cardiovascular health study.
22613962 Genetic influences on vitamin D status and forearm fracture risk in African American children.
22629401 Evaluation of genetic markers as instruments for Mendelian randomization studies on vitamin D.
23319826 Vitamin D and mortality: a Mendelian randomization study.
23793229 Association of common gene variants in vitamin D modulating genes and colon cancer recurrence.
26038244 Genetic Variation in CYP2R1 and GC Genes Associated With Vitamin D Deficiency Status.
26141257 Low vitamin D status is associated with more depressive symptoms in Dutch older adults.
26446360 Mendelian randomization studies of biomarkers and type 2 diabetes.
27215954 Investigating causality in the association between 25(OH)D and schizophrenia.
27331016 ERBB3-rs2292239 as primary type 1 diabetes association locus among non-HLA genes in Chinese.
27366029 Vitamin D deficiency in patients with liver cirrhosis.
27756067 Determinants of Neonatal Vitamin D Levels as Measured on Neonatal Dried Blood Spot Samples.
28938476 Fetal and Maternal Genetic Variants Influencing Neonatal Vitamin D Status.
29038561 Vitamin D and cognitive function: A Mendelian randomisation study.
29089348 Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study.
29291743 SNPs related to vitamin D and breast cancer risk: a case-control study.
29514138 Effects of Gene Variants Controlling Vitamin D Metabolism and Serum Levels on Hepatic Steatosis.
29718335 Negative effect of vitamin D on kidney function: a Mendelian randomization study.
29892565 The genetic determinants of circulating C3-epimers of 25-hydroxyvitamin D.
29925546 Vitamin D and risk of pregnancy related hypertensive disorders: mendelian randomisation study.
31218665 Is there a causal relationship between vitamin D and melanoma risk? A Mendelian randomization study.
31357732 Association of Vitamin D Pathway Genetic Variation and Thyroid Cancer.
31475028 Host Genetic Determinants of Hepatitis B Virus Infection.
32593521 Higher levels of 25-hydroxyvitamin D are associated with an increased risk of Bechsche's disease.
32764491 Vitamin D Pathway Genetic Variation and Type 1 Diabetes: A Case-Control Association Study.
33763108 Whole Genome Interpretation for a Family of Five.
34150833 Association of Vitamin D, Zinc and Selenium Related Genetic Variants With COVID-19 Disease Severity.
34959812 Vitamin D and Type 1 Diabetes Risk: A Systematic Review and Meta-Analysis of Genetic Evidence.
35760298 Genetic control of serum 25(OH)D levels and its association with ethnicity.
36012386 Vitamin D-Related Genetic Variations and Nonalcoholic Fatty Liver Disease: A Systematic Review.