SNP information rs1143679

Research and publications:

  18204448   A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.

  19129174   Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).

  19286673   ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai.

  19440199   Recent insights into the genetic basis of systemic lupus erythematosus.

  19442287   Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study.

  19714582   Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors.

  19849816   Genetics of rheumatic disease.

  19939855   ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry.

  20112382   Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: evidence of a general susceptibility locus.

  20209114   Infection in systemic lupus erythematosus: friend or foe?

  20338887   Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases.

  20441431   Recent advances in the genetics of systemic lupus erythematosus.

  20629846   Association of ITGAM polymorphism with systemic lupus erythematosus: a meta-analysis.

  20666624   ITGAM Arg77His is associated with disease susceptibility, arthritis, and renal symptoms in systemic lupus erythematosus patients from a sample of the Polish population.

  20848568   Genetically determined Amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus.

  20881011   Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients.

  20933377   Recent findings on genetics of systemic autoimmune diseases.

  21060334   Genetic susceptibility to systemic lupus erythematosus in the genomic era.

  21151989   Polymorphisms of the ITGAM gene confer higher risk of discoid cutaneous than of systemic lupus erythematosus.

  21362770   Association study of ITGAM, ITGAX, and CD58 autoimmune risk loci in systemic sclerosis: results from 2 large European Caucasian cohorts.

  21719445   Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus.

  21765104   Evaluation of 19 autoimmune disease-associated loci with rheumatoid arthritis in a Colombian population: evidence for replication and gene-gene interaction.

  21792837   Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study.

  21965647   A nonsynonymous functional variant of the ITGAM gene is not involved in biopsy-proven giant cell arteritis.

  22110124   Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus.

  22174698   A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap.

  22523428   Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries.

  22536486   Lupus nephritis: an overview of recent findings.

  22541939   Bias in effect size of systemic lupus erythematosus susceptibility loci across Europe: a case-control study.

  22577522   Shared HLA Class II in Six Autoimmune Diseases in Latin America: A Meta-Analysis.

  22586164   The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes.

  22640752   The genetics of lupus: a functional perspective.

  22922229   Seven newly identified loci for autoimmune thyroid disease.

  23000205   Gene network analysis of small molecules with autoimmune disease associated genes predicts a novel strategy for drug efficacy.

  23049788   Further evidence of subphenotype association with systemic lupus erythematosus susceptibility loci: a European cases only study.

  23227085   Genetics of SLE: functional relevance for monocytes/macrophages in disease.

  23386618   Complement receptor 3 influences toll-like receptor 7/8-dependent inflammation: implications for autoimmune diseases characterized by antibody reactivity to ribonucleoproteins.

  23918739   Multiple lupus-associated ITGAM variants alter Mac-1 functions on neutrophils.

  24264377   Integrin CD11b negatively regulates BCR signalling to maintain autoreactive B cell tolerance.

  24269694   The variant of CD11b, rs1143679 within ITGAM, is associated with systemic lupus erythematosus and clinical manifestations in Brazilian patients.

  24386384   Association of STAT4 polymorphism with severe renal insufficiency in lupus nephritis.

  24608226   Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM.

  24871463   GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.

  24886912   Resequencing the susceptibility gene, ITGAM, identifies two functionally deleterious rare variants in systemic lupus erythematosus cases.

  24946689   Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus.

  25315704   Association between the functional ITGAM rs1143679 G/A polymorphism and systemic lupus erythematosus/lupus nephritis or rheumatoid arthritis: an update meta-analysis.

  25328554   Systemic Sclerosis is a Complex Disease Associated Mainly with Immune Regulatory and Inflammatory Genes.

  25338677   Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus.

  25569146   Systems level analysis of systemic sclerosis shows a network of immune and profibrotic pathways connected with genetic polymorphisms.

  26106387   Pathogenesis of Systemic Sclerosis.

  26606652   Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture.

  26683153   The many faces of Mac-1 in autoimmune disease.

  26773105   Genetic Variants That Are Associated with Neuropsychiatric Systemic Lupus Erythematosus.

  26798662   Genetic Factors in Systemic Lupus Erythematosus: Contribution to Disease Phenotype.

  26808113   High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry.

  26950932   Serological and Genetic Evidence for Altered Complement System Functionality in Systemic Lupus Erythematosus: Findings of the GAPAID Consortium.

  27118513   The complement receptor 3 (CD11b/CD18) agonist Leukadherin-1 suppresses human innate inflammatory signalling.

  27306948   Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study.

  27536670   Lupus Nephritis in Asia: Clinical Features and Management.

  27693588   Genetics of human lupus nephritis.

  28670251   Genetic similarities and differences between discoid and systemic lupus erythematosus patients within the Polish population.

  29207897   Association of the CD11b rs1143679 polymorphism with systemic lupus erythematosus in the Han Chinese population.

  30041578   Association of ITGAM, TNFSF4, TNFAIP3 and STAT4 gene polymorphisms with risk of systemic lupus erythematosus in a North Indian population.

  30179587   Precision medicine in lupus nephritis: can biomarkers get us there?

  30498196   Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment.

  31659207   Rare variants in non-coding regulatory regions of the genome that affect gene expression in systemic lupus erythematosus.

  31673770   Mice expressing the variant rs1143679 allele of ITGAM (CD11b) show impaired DC-mediated T cell proliferation.

  31774828   ITGAM is a risk factor to systemic lupus erythematosus and possibly a protection factor to rheumatoid arthritis in patients from Mexico.

  32785810   Clinical features and expression of type I interferon-inducible genes in systemic lupus erythematosus patients harboring rs1143679 polymorphism in China: a single-center, retrospective study.

  34519938   Association between complement gene polymorphisms and systemic lupus erythematosus: a systematic review and meta-analysis.

  34847931   Single-cell expression quantitative trait loci (eQTL) analysis of SLE-risk loci in lupus patient monocytes.