SNP information rs8034191

Research and publications:

  18385676   Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

  18759969   In search of causal variants: refining disease association signals using cross-population contrasts

  18780872   Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer

  18957677   The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer

  19029397   Nicotinic receptor gene variants influence susceptibility to heavy smoking

  19064933   Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans

  19247474   Genome-wide and candidate gene association study of cigarette smoking behaviors

  19259974   Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes

  19300482   A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci

  19300500   A genome-wide association study of pulmonary function measures in the Framingham Heart Study.

  19465454   The TERT-CLPTM1L lung cancer susceptibility variant associates with higher DNA adduct formation in the lung

  19474294   Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

  19639606   Correcting the “winner's curse” in odds ratios based on genome-wide association results for major complex human diseases.

  19641473   Racial differences in the association between SNPs on 15q25.1, smoking behavior, and risk of non-small cell lung cancer

  19654303   Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.

  19706762   The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans

  19733931   Blood-based CHRNA3 single nucleotide polymorphism and outcome in advanced non-small-cell lung cancer patients

  19741265   Genetics and genomics of chronic obstructive pulmonary disease.

  19776245   Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals

  19789337   Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1

  19800047   Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene.

  19836008   A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.

  19859904   Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans

  19903803   Re: Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk.

  19951401   Chronic obstructive pulmonary disease: towards pharmacogenetics

  20010835   Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.

  20056643   A rigorous and comprehensive validation: common genetic variations and lung cancer

  20068085   Analysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: a preliminary report.

  20142248   Cumulative effect of multiple loci on genetic susceptibility to familial lung cancer.

  20348396   A general framework for studying genetic effects and gene-environment interactions with missing data.

  20395203   A second genetic variant on chromosome 15q24-25.1 associates with lung cancer

  20505153   A compendium of genome-wide associations for cancer: critical synopsis and reappraisal.

  20548021   Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium

  20554942   Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study

  20585100   Genome-wide association studies of cancer.

  20656943   Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease

  20833654   Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes.

  21081471   Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study

  21168125   TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood

  21219822   [Recent progress in genetic variants associated with cancer and their implications in diagnostics development].

  21228559   A preliminary study of the CHRNA3-CHRNA5-CHRNB4 cluster, smoking and Parkinson's disease.

  21229299   Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers

  21232152   Epidemiology, radiology, and genetics of nicotine dependence in COPD.

  21320324   The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study.

  21500120   Lung cancer in never smokers

  21533024   Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci

  21559498   Chromosome 15q25 (CHRNA3-CHRNA5) variation impacts indirectly on lung cancer risk

  21685187   Genome-wide association study of smoking behaviours in patients with COPD

  21697764   Susceptibility locus for lung cancer at 15q25.1 is not associated with risk of pancreatic cancer

  21750227   Single-nucleotide polymorphisms (5p15.33, 15q25.1, 6p22.1, 6q27 and 7p15.3) and lung cancer survival in the European Prospective Investigation into Cancer and Nutrition (EPIC).

  21810735   Single nucleotide polymorphisms in CHRNA5 rs16969968, CHRNA3 rs578776, and LOC123688 rs8034191 are associated with heaviness of smoking in women in Northeastern Ontario, Canada.

  21921092   Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease.

  21929786   Significance testing in ridge regression for genetic data.

  21949713   Genetics of sputum gene expression in chronic obstructive pulmonary disease.

  21966413   Smoking related cancers and loci at chromosomes 15q25, 5p15, 6p22.1 and 6p21.33 in the Polish population.

  22017462   Alpha-nicotinic acetylcholine receptor and tobacco smoke exposure: effects on bronchial hyperresponsiveness in children.

  22028403   A case-control study of a sex-specific association between a 15q25 variant and lung cancer risk.

  22074863   N-acetyltransferase 2 polymorphisms, tobacco smoking, and breast cancer risk in the breast and prostate cancer cohort consortium.

  22080838   A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.

  22176972   Nicotinic acetylcholine receptor variants associated with susceptibility to chronic obstructive pulmonary disease: a meta-analysis.

  22276117   The association between ATM IVS 22-77 T>C and cancer risk: a meta-analysis.

  22356581   Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency.

  22438921   Nicotinic acetylcholine receptor variants are related to smoking habits, but not directly to COPD.

  22461431   CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland.

  22701590   Strong association between two polymorphisms on 15q25.1 and lung cancer risk: a meta-analysis.

  22793939   Genes and chronic obstructive pulmonary disease.

  22854838   The influence of race and ethnicity on the biology of cancer.

  22889990   Natural and orthogonal interaction framework for modeling gene-environment interactions with application to lung cancer.

  22899653   Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.

  22914670   Association of IREB2 and CHRNA3/5 polymorphisms with COPD and COPD-related phenotypes in a Chinese Han population.

  22945651   Epigenetic screen identifies genotype-specific promoter DNA methylation and oncogenic potential of CHRNB4.

  23029550   Associations between variation in CHRNA5-CHRNA3-CHRNB4, body mass index and blood pressure in the Northern Finland Birth Cohort 1966.

  23055711   Updates on the COPD gene list.

  23056235   Functional polymorphisms of CHRNA3 predict risks of chronic obstructive pulmonary disease and lung cancer in Chinese.

  23090857   Emerging genetics of COPD.

  23221128   Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans.

  23255854   A functional polymorphism in the CHRNA3 gene and risk of chronic obstructive pulmonary disease in a Korean population.

  23299987   Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility.

  23349013   Genetic susceptibility to lung cancer--light at the end of the tunnel?

  23349703   Variants in the 15q24/25 locus associate with lung function decline in active smokers.

  23408875   Get more out of your biomedical documents with GATE's full lifecycle open source text analytics.

  23691092   Associations of prenatal nicotine exposure and the dopamine related genes ANKK1 and DRD2 to verbal language.

  23820649   Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease

  23844051   Association of CHRNA5-A3-B4 variation with esophageal squamous cell carcinoma risk and smoking behaviors in a Chinese population.

  24065931   The CHRNA3 rs578776 Variant is Associated with an Intrinsic Reward Sensitivity Deficit in Smokers.

  24254305   Quantitative assessment of the influence of common variations (rs8034191 and rs1051730) at 15q25 and lung cancer risk.

  24563194   Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema.

  24588897   CHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women.

  24686516   CHRNA3 polymorphism modifies lung adenocarcinoma risk in the Chinese Han population.

  25036316   Joint association of nicotinic acetylcholine receptor variants with abdominal obesity in American Indians: the Strong Heart Family Study.

  25051068   Four SNPs in the CHRNA3/5 alpha-neuronal nicotinic acetylcholine receptor subunit locus are associated with COPD risk based on meta-analyses.

  25074529   Genetic association between AGPHD1 variant and lung cancer risk.

  25233467   Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma.

  25288178   The association between the rs6495309 polymorphism in CHRNA3 gene and lung cancer risk in Chinese: a meta-analysis.

  25302169   Acetylcholine receptor pathway in lung cancer: New twists to an old story.

  25329654   Role of a genetic variant on the 15q25.1 lung cancer susceptibility locus in smoking-associated nasopharyngeal carcinoma.

  25551457   No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects.

  25642160   Nicotinic receptor modulation to treat alcohol and drug dependence.

  25778907   The DYX2 locus and neurochemical signaling genes contribute to speech sound disorder and related neurocognitive domains.

  25874685   CHRNA3 rs6495308 genotype as an effect modifier of the association between daily cigarette consumption and hypertension in Chinese male smokers.