SNP information rs729302

Research and publications:

  15657875   Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.

  17389033   Replication of the genetic effects of IFN regulatory factor 5 (IRF5) on systemic lupus erythematosus in a Korean population.

  17412832   Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.

  17568788   Opposed independent effects and epistasis in the complex association of IRF5 to SLE.

  18063667   Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus.

  18285424   Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations.

  18408250   A single nucleotide polymorphism in the IRF5 promoter region is associated with susceptibility to rheumatoid arthritis in the Japanese population.

  19228650   Association of polymorphisms in interferon regulatory factor 5 gene with rheumatoid arthritis: a metaanalysis.

  19440200   Identification of new SLE-associated genes with a two-step Bayesian study design

  20169177   Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus.

  20453842   Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

  20479942   Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap.

  20662065   Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus.

  20881011   Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients.

  21239750   Association of IRF5 polymorphisms with susceptibility to macrophage activation syndrome in patients with juvenile idiopathic arthritis.

  21627826   Cis-regulation of IRF5 expression is unable to fully account for systemic lupus erythematosus association: analysis of multiple experiments with lymphoblastoid cell lines.

  21834935   A meta-analysis of the association of IRF5 polymorphism with systemic lupus erythematosus.

  21898142   Association of IRF5 polymorphisms with susceptibility to hemophagocytic lymphohistiocytosis in children.

  22110124   Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus.

  22162633   Activation of type I interferon pathway in systemic lupus erythematosus: association with distinct clinical phenotypes.

  22541939   Bias in effect size of systemic lupus erythematosus susceptibility loci across Europe: a case-control study.

  22544929   IRF5 risk polymorphisms contribute to interindividual variance in pattern recognition receptor-mediated cytokine secretion in human monocyte-derived cells.

  23049788   Further evidence of subphenotype association with systemic lupus erythematosus susceptibility loci: a European cases only study.

  23073787   Associations between interferon regulatory factor 5 polymorphisms and rheumatoid arthritis: a meta-analysis.

  23288367   Interferon regulatory factor 5 polymorphisms in sarcoidosis.

  23941291   Identification of three new cis-regulatory IRF5 polymorphisms: in vitro studies.

  24946689   Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus.

  25337792   Genetic association study of TNFAIP3, IFIH1, IRF5 polymorphisms with polymyositis/dermatomyositis in Chinese Han population.

  30168487   The IRF5 rs2004640 (G/T) polymorphism is not a genetic risk factor for systemic lupus erythematosus in population from south India.