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SNP information rs7041

RS7041

Normal allele: AA

Vitamin D binding protein genotype and osteoporosis. Associated with decreased 25-hydroxyvitamin D concentrations. A study of smokers found that vitamin D levels were reduced by 25% with this breakdown and 2 times the risk of chronic obstructive pulmonary disease. Also associated with metabolic syndrome and lower levels of 25-hydroxyvitamin D in polycystic ovary syndrome.

Polymorphism rs7041 is related to topics like this:

Genetic vitamin D deficiency

Vitamin D plays a vital role in maintaining musculoskeletal health. Recent studies have linked...


Research and publications:

  1352271   Molecular analysis of the gene for the human vitamin-D-binding protein (group-specific component): allelic differences of the common genetic GC types.

  15660291   Population structure, admixture, and aging-related phenotypes in African American adults: the Cardiovascular Health Study.

  15726497   Gene-environment interaction effects on the development of immune responses in the 1st year of life

  15817713   Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations

  16600026   Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway

  17054776   The genetics of chronic obstructive pulmonary disease

  17244366   Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study

  17903307   Framingham Heart Study genome-wide association: results for pulmonary function measures.

  18559548   The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status.

  18593774   Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans

  19116321   Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women.

  19131662   A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients

  19255064   Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk

  19263529   Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach

  19330901   Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study

  19488670   Vitamin D binding protein genotype and osteoporosis.

  19559392   A candidate gene association study of 77 polymorphisms in migraine

  19951401   Chronic obstructive pulmonary disease: towards pharmacogenetics

  19996341   Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene.

  20007432   Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosis

  20086113   Genetic variation in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer: results from the Colon Cancer Family Registry

  20363324   A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations.

  20418485   Genome-wide association study of circulating vitamin D levels.

  20541252   Common genetic determinants of vitamin D insufficiency: a genome-wide association study.

  20600896   Genome-wide association study of vitamin D concentrations in Hispanic Americans: the IRAS family study.

  20812960   Vitamin D-binding protein polymorphisms are not associated with development of (multiple) basal cell carcinomas.

  21228423   Vitamin D-binding protein contributes to COPD by activation of alveolar macrophages.

  21273692   Comparing genetic ancestry and self-reported race/ethnicity in a multiethnic population in New York City.

  21357399   Vitamin D receptor (VDR) and group-specific component (GC, vitamin D-binding protein) polymorphisms in myopia

  21430387   Nutrigenomics, vitamin D and cancer prevention

  21431378   Genetic predictors of 25-hydroxyvitamin D levels and risk of multiple sclerosis.

  21441443   Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes

  21693626   Vitamin D-related genetic variants, interactions with vitamin D exposure, and breast cancer risk among Caucasian women in Ontario.

  21754915   Capitalizing on admixture in genome-wide association studies: a two-stage testing procedure and application to height in African-Americans.

  21810276   Vitamin D binding protein variants associate with asthma susceptibility in the Chinese Han population.

  21828234   Common genetic variants in the vitamin D pathway including genome-wide associated variants are not associated with breast cancer risk among Chinese women

  21844098   Reduced serum vitamin D-binding protein levels are associated with type 1 diabetes.

  21877163   The Rotterdam Study: 2012 objectives and design update.

  21972121   Associations between common variants in GC and DHCR7/NADSYN1 and vitamin D concentration in Chinese Hans.

  22129377   Nutrigenomics and personalized diets: What will they mean for food?

  22144504   Polymorphic variation in the GC and CASR genes and associations with vitamin D metabolite concentration and metachronous colorectal neoplasia.

  22205958   Common variation in vitamin D pathway genes predicts circulating 25-hydroxyvitamin D Levels among African Americans.

  22213340   25-hydroxyvitamin D, vitamin D receptor gene polymorphism and severity of Parkinson's disease.

  22576141   No association of vitamin D metabolism-related polymorphisms and melanoma risk as well as melanoma prognosis: a case-control study.

  22583563   Genetic and environmental predictors of serum 25-hydroxyvitamin D concentrations among middle-aged and elderly Chinese in Singapore.

  22610885   Vitamin D binding protein gene polymorphisms and baseline vitamin D levels as predictors of antiviral response in chronic hepatitis C.

  22649517   Polymorphisms related to the serum 25-hydroxyvitamin D level and risk of myocardial infarction, diabetes, cancer and mortality. The Tromsø Study.

  22769019   Association of inflammatory gene polymorphisms with ischemic stroke in a Chinese Han population.

  23185470   Vitamin D in a northern Canadian first nation population: dietary intake, serum concentrations and functional gene polymorphisms.

  23427793   Common variants of the vitamin D binding protein gene and adverse health outcomes.

  23456391   Serum vitamin D metabolites in colorectal cancer patients receiving cholecalciferol supplementation: correlation with polymorphisms in the vitamin D genes.

  23505139   An analysis of the association between the vitamin D pathway and serum 25-hydroxyvitamin D levels in a healthy Chinese population.

  23730842   Association of vitamin D serum levels and its common genetic determinants, with severity of liver fibrosis in genotype 1 chronic hepatitis C patients.

  23833127   Pesticide exposure and inherited variants in vitamin d pathway genes in relation to prostate cancer.

  24200978   Serum 25(OH)D and vitamin D status in relation to VDR, GC and CYP2R1 variants in Chinese.

  24447085   Vitamin D-binding protein haplotype is associated with hospitalization for RSV bronchiolitis.

  24472850   Associations between vitamin D-binding protein isotypes, circulating 25(OH)D levels, and vitamin D metabolite uptake in colon cancer cells.

  24516573   Vitamin D levels vary during antiviral treatment but are unable to predict treatment outcome in HCV genotype 1 infected patients.

  24663808   A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima-media thickness).

  24735339   Association of group component genetic variations in COPD and COPD exacerbation in a Japanese population.

  24768180   Vitamin-D pathway genes and HIV-1 disease progression in injection drug users.

  24868205   Vitamin D Binding Protein Impact on 25-Hydroxyvitamin D Levels under Different Physiologic and Pathologic Conditions.

  25046415   The functional polymorphisms of VDR, GC and CYP2R1 are involved in the pathogenesis of autoimmune thyroid diseases.

  25211176   Determinants of vitamin D status in Caucasian adults: influence of sun exposure, dietary intake, sociodemographic, lifestyle, anthropometric, and genetic factors.

  25234352   Genetic and environmental influences on plasma vitamin D binding protein concentrations.

  25405862   Vitamin D insufficiency in Arabs and South Asians positively associates with polymorphisms in GC and CYP2R1 genes.

  25488826   Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: a nested case-control study.

  25533295   Genetic and environmental determinants of 25-hydroxyvitamin D levels in multiple sclerosis.

  25541958   Association of single nucleotide polymorphisms in VDR and DBP genes with HBV-related hepatocellular carcinoma risk in a Chinese population.

  25587543   T-cell cytokine gene polymorphisms and vitamin D pathway gene polymorphisms in end-stage renal disease due to type 2 diabetes mellitus nephropathy: comparisons with health status and other main causes of end-stage renal disease.

  25652210   Vitamin D binding protein genotype is associated with plasma 25OHD concentration in West African children.

  25920689   The associations of 25-hydroxyvitamin D levels, vitamin D binding protein gene polymorphisms, and race with risk of incident fracture-related hospitalization: Twenty-year follow-up in a bi-ethnic cohort (the ARIC Study).

  25926504   Race, vitamin D-binding protein gene polymorphisms, 25-hydroxyvitamin D, and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) Study.

  25941991   25-hydroxyvitamin D levels, vitamin D binding protein gene polymorphisms and incident coronary heart disease among whites and blacks: The ARIC study.

  25962507   Vitamin D, vitamin D binding protein gene polymorphisms, race and risk of incident stroke: the Atherosclerosis Risk in Communities (ARIC) study.

  25993607   Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.

  26067474   Association of vitamin D binding protein polymorphisms with bronchopulmonary dysplasia: a case-control study of gc globulin and bronchopulmonary dysplasia.

  26193879   Genotype-independent association between profound vitamin D deficiency and delayed sputum smear conversion in pulmonary tuberculosis.

  26260969   Polymorphisms affecting vitamin D-binding protein modify the relationship between serum vitamin D (25[OH]D3) and food allergy.

  26317560   Bioavailable Vitamin D in Obese Children: The Role of Insulin Resistance.

  26356094   Critically Ill Children Have Low Vitamin D-Binding Protein, Influencing Bioavailability of Vitamin D.

  26364161   Meta-analysis of vitamin D-binding protein and cancer risk.

  26380769   Vitamin D binding protein gene polymorphisms and chronic obstructive pulmonary disease: a meta-analysis.

  26383826   Association of rs7041 and rs4588 Polymorphisms of the Vitamin D Binding Protein and the rs10741657 Polymorphism of CYP2R1 with Vitamin D Status Among Jordanian Patients.

  26398313   Polymorphic variants in vitamin D signaling pathway genes and the risk of endometriosis-associated infertility.

  26404398   Hypovitaminosis D in a Young Lebanese Population: Effect of GC Gene Polymorphisms on Vitamin D and Vitamin D Binding Protein Levels.

  26497592   The rs1803274 polymorphism of the BCHE gene is associated with an increased risk of coronary in-stent restenosis.

  26610845   Association of Retinoid X Receptor Alpha Gene Polymorphism with Clinical Course of Chronic Glomerulonephritis.

  26872154   Low Vitamin-D Levels Combined with PKP3-SIGIRR-TMEM16J Host Variants Is Associated with Tuberculosis and Death in HIV-Infected and -Exposed Infants.

  26881316   Independent associations of polymorphisms in vitamin D binding protein (GC) and vitamin D receptor (VDR) genes with obesity and plasma 25OHD3 levels demonstrate sex dimorphism.

  26893716   Polymorphic variants in the vitamin D pathway genes and the risk of ovarian cancer among non-carriers of BRCA1/BRCA2 mutations.

  26962819   GC Gene Polymorphism and Unbound Serum Retinol-Binding Protein 4 Are Related to the Risk of Insulin Resistance in Patients With Chronic Hepatitis C: A Prospective Cross-Sectional Study.

  27032714   Admixture mapping of serum vitamin D and parathyroid hormone concentrations in the African American-Diabetes Heart Study.

  27116295   Serum Bioavailable Vitamin D Concentrations and Bone Mineral Density in Women After Obesity Surgery.

  27154872   Vitamin D status in primary hyperparathyroidism: effect of genetic background.

  27160686   Vitamin D deficiency associates with susceptibility to tuberculosis in Pakistan, but polymorphisms in VDR, DBP and CYP2R1 do not.

  27532455   Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.

  27570856   Genetic influence on circulating vitamin D among Saudi Arabians.

  27625044   Genetically Low Vitamin D Levels, Bone Mineral Density, and Bone Metabolism Markers: a Mendelian Randomisation Study.

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