SNP information rs6920220

Research and publications:

  17982455   Rheumatoid arthritis association at 6q23.

  17982456   Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.

  18625055   Lack of association or interactions between the IL-4, IL-4Ralpha and IL-13 genes, and rheumatoid arthritis.

  18794853   Common variants at CD40 and other loci confer risk of rheumatoid arthritis

  18794857   Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.

  18853133   Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.

  18987647   Rheumatoid arthritis: a view of the current genetic landscape

  19165918   Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

  19165919   Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus.

  19169254   Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.

  19180477   Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations

  19292917   Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-kappaB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility.

  19321514   6q23 polymorphisms in rheumatoid arthritis Spanish patients.

  19366996   Association of the 6q23 region with the rate of joint destruction in rheumatoid arthritis.

  19387456   Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations.

  19401279   Susceptibility variants for rheumatoid arthritis in the TRAF1-C5 and 6q23 loci: a meta-analysis.

  19417005   Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23.

  19439038   Complex genetic association of 6q23 with autoimmune rheumatic conditions.

  19445664   Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as controls

  19565500   Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis

  19674979   Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.

  19838195   A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

  19898481   Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

  19956648   Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases.

  20017963   Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritis.

  20018027   Conditional analysis of the major histocompatibility complex in rheumatoid arthritis.

  20075733   Recent advances in the genetics of rheumatoid arthritis.

  20219786   The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register.

  20231195   Lack of association between the rs6920220 (G/A) polymorphism of the 6q23 region and biopsy-proven giant cell arteritis.

  20233754   Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk.

  20309765   Bagging optimal ROC curve method for predictive genetic tests, with an application for rheumatoid arthritis.

  20309874   Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy.

  20338887   Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases.

  20353580   Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort.

  20426808   AntEpiSeeker: detecting epistatic interactions for case-control studies using a two-stage ant colony optimization algorithm.

  20439292   Genetic variants in the prediction of rheumatoid arthritis.

  20441431   Recent advances in the genetics of systemic lupus erythematosus.

  20444755   Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.

  20453842   Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

  20461788   Association of a rheumatoid arthritis susceptibility variant at the CCL21 locus with premature mortality in inflammatory polyarthritis patients.

  20498205   Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers.

  20510233   Leveraging human genetics to develop future therapeutic strategies in rheumatoid arthritis.

  20511617   Association of the TNFAIP3 rs5029939 variant with systemic sclerosis in the European Caucasian population.

  20549515   Genome-wide searching of rare genetic variants in WTCCC data.

  20617138   Association of TNFAIP3 polymorphism with susceptibility to systemic lupus erythematosus in a Japanese population.

  20722033   The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.

  20805105   Synthetic associations in the context of genome-wide association scan signals

  20822710   Functional evaluation of TNFAIP3 (A20) in rheumatoid arthritis.

  20921970   A genetic marker at the OLIG3/TNFAIP3 locus associates with methotrexate continuation in early inflammatory polyarthritis: results from the Norfolk Arthritis Register.

  20933377   Recent findings on genetics of systemic autoimmune diseases.

  21120996   Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans.

  21156761   A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.

  21211616   Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records.

  21217814   Presymptomatic risk assessment for chronic non-communicable diseases.

  21297633   Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

  21383967   Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.

  21833526   A Tunisian case-control association study of a 6q polymorphism in rheumatoid arthritis.

  21931699   Genetic risk score predicting risk of rheumatoid arthritis phenotypes and age of symptom onset.

  21980439   A systems genetics approach provides a bridge from discovered genetic variants to biological pathways in rheumatoid arthritis.

  22328738   Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.

  22402800   Associations between TNFAIP3 gene polymorphisms and rheumatoid arthritis: a meta-analysis.

  22541939   Bias in effect size of systemic lupus erythematosus susceptibility loci across Europe: a case-control study.

  22661644   Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients.

  22770979   Presence of multiple independent effects in risk loci of common complex human diseases.

  22798268   Rheumatoid arthritis-associated polymorphisms at 6q23 are associated with radiological damage in autoantibody-positive RA.

  22843550   Genetic variation and alterations of genes involved in NFκB/TNFAIP3- and NLRP3-inflammasome signaling affect susceptibility and outcome of colorectal cancer.

  22936693   Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants.

  23000205   Gene network analysis of small molecules with autoimmune disease associated genes predicts a novel strategy for drug efficacy.

  23049788   Further evidence of subphenotype association with systemic lupus erythematosus susceptibility loci: a European cases only study.

  23121884   Investigation of Caucasian rheumatoid arthritis susceptibility loci in African patients with the same disease.

  23133455   TNF-α Polymorphisms in Juvenile Idiopathic Arthritis: Which Potential Clinical Implications?

  23226040   Pharmacogenetics of rheumatoid arthritis: Potential targets from susceptibility genes and present therapies.

  23251581   Meta-analysis of 125 rheumatoid arthritis-related single nucleotide polymorphisms studied in the past two decades.

  23450725   Susceptibility to childhood-onset rheumatoid arthritis: investigation of a weighted genetic risk score that integrates cumulative effects of variants at five genetic loci.

  24068971   Predicting the risk of rheumatoid arthritis and its age of onset through modelling genetic risk variants with smoking.

  24069534   Genetics of psoriasis and pharmacogenetics of biological drugs.

  24449572   Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.

  24884566   Single nucleotide polymorphisms in TNFAIP3 were associated with the risks of rheumatoid arthritis in northern Chinese Han population.

  24971370   Alternative expression pattern of MALT1-A20-NF-κB in patients with rheumatoid arthritis.

  25674272   TNFAIP3 rs2230926 polymorphisms in rheumatoid arthritis of southern Chinese Han population: a case-control study.

  26143186   Characteristics of A20 gene polymorphisms and clinical significance in patients with rheumatoid arthritis.

  26504858   Genetic Predictors of Poor Prognosis in Portuguese Patients with Juvenile Idiopathic Arthritis: Data from Reuma.pt.

  26613086   Polymorphisms Associated with Age at Onset in Patients with Moderate-to-Severe Plaque Psoriasis.

  26843965   Identification of rheumatoid arthritis biomarkers based on single nucleotide polymorphisms and haplotype blocks: A systematic review and meta-analysis.

  27156530   Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility.

  27799070   Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23.

  28199970   Three single nucleotide polymorphisms of TNFAIP3 gene increase the risk of rheumatoid arthritis.

  28448618   rs10499194 polymorphism in the tumor necrosis factor-α inducible protein 3 (TNFAIP3) gene is associated with type-1 autoimmune hepatitis risk in Chinese Han population.

  30336268   Genetic variants upstream of TNFAIP3 in the 6q23 region are associated with liver disease severity in HIV/HCV-coinfected patients: A cross-sectional study.

  30813592   TNFAIP3, TNIP1, and MyD88 Polymorphisms Predict Septic-Shock-Related Death in Patients Who Underwent Major Surgery.

  30888520   Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes.

  31131138   Identification of functional missense single-nucleotide polymorphisms in TNFAIP3 in a predominantly Hispanic population.

  31134135   Pleiotropic Meta-Analysis of Age-Related Phenotypes Addressing Evolutionary Uncertainty in Their Molecular Mechanisms.

  31534975   TNFAIP3 Gene Polymorphisms in Three Common Autoimmune Diseases: Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Primary Sjogren Syndrome-Association with Disease Susceptibility and Clinical Phenotypes in Italian Patients.

  32671985   Inherited variant in NFκB-1 promoter is associated with increased risk of IBD in an Algerian population and modulates SOX9 binding.

  32831971   Investigating the GWAS-Implicated Loci for Rheumatoid Arthritis in the Pakistani Population.

  33995606   Biomarkers predictive of treatment response in psoriasis and psoriatic arthritis: a systematic review.

  34573380   Pharmacogenomics: An Update on Biologics and Small-Molecule Drugs in the Treatment of Psoriasis.