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SNP information rs6189


Normal allele: CC

A genetic variant in the glucocorticoid receptor gene increases the severity of PTSD and depressive disorders.

Polymorphism rs6189 is related to topics like this:

21 hydroxylase

The CYP21A2 gene encodes the human protein, Steroid 21-hydroxylase. This enzyme hydroxylates...

Research and publications:

  9150737   Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance.

  12351458   A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels.

  15276593   Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men.

  15292341   The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults.

  16030164   Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression.

  17848410   The 23K variant of the R23K polymorphism in the glucocorticoid receptor gene protects against postnatal growth failure and insulin resistance after preterm birth.

  19673019   IL-10 and TNF-alpha promoter haplotypes are associated with the location of Crohn's disease in children

  20440229   Glucocorticoid receptor gene polymorphisms in Italian patients with eating disorders and obesity.

  20547006   FKBP5 and resistant attachment predict cortisol reactivity in infants: gene-environment interaction.

  20549395   Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies

  20712049   Glucocorticoid receptor gene haplotype structure and steroid therapy outcome in IBD patients.

  21164266   Glucocorticoid resistance.

  21225419   Gene-environment interactions: early life stress and risk for depressive and anxiety disorders.

  21448414   Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease

  22427805   Glucocorticoid receptor 1B and 1C mRNA transcript alterations in schizophrenia and bipolar disorder, and their possible regulation by GR gene variants.

  22445700   The impact of drug metabolizing enzyme polymorphisms on outcomes after antenatal corticosteroid use.

  22507373   Glucocorticoid receptor gene polymorphisms are associated with reduced first-phase glucose-stimulated insulin secretion and disposition index in women, but not in men.

  22781842   Variation in the glucocorticoid receptor gene at rs41423247 moderates the effect of prenatal maternal psychological symptoms on child cortisol reactivity and behavior.

  23055001   Genetic evidence for the association of the hypothalamic-pituitary-adrenal (HPA) axis with ADHD and methylphenidate treatment response.

  24497894   A Conceptual Model of Psychoneurological Symptom Cluster Variation in Women with Breast Cancer: Bringing Nursing Research to Personalized Medicine.

  25644744   Single nucleotide polymorphisms in non-coding region of the glucocorticoid receptor gene and prednisone response in childhood acute lymphoblastic leukemia.

  25724472   Polymorphisms in the glucocorticoid receptor gene and in the glucocorticoid-induced transcript 1 gene are associated with disease activity and response to glucocorticoid bridging therapy in rheumatoid arthritis.

  25741362   Use of pharmacogenomics in pediatric renal transplant recipients.

  26518448   Case-control study of glucocorticoid receptor and corticotrophin-releasing hormone receptor gene variants and risk of perinatal depression.

  26821164   Glucocorticoid Receptor (NR3C1) Variants Associate with the Muscle Strength and Size Response to Resistance Training.

  26823689   The cardiovascular and hypothalamus-pituitary-adrenal axis response to stress is controlled by glucocorticoid receptor sequence variants and promoter methylation.

  26873309   Glucocorticoid receptor polymorphisms modulate cardiometabolic risk factors in patients with long-term remission of Cushing's syndrome.

  27081784   A novel approach to understanding the role of polymorphic forms of the NR3C1 and TGF-β1 genes in the modulation of the expression of IL-5 and IL-15 mRNA in asthmatic inflammation.

  27507764   HPA axis dysregulation, NR3C1 polymorphisms and glucocorticoid receptor isoforms imbalance in metabolic syndrome.

  27528460   HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition.

  28364727   Hypothalamic-pituitary-adrenal axis genetic variation and early stress moderates amygdala function.

  28641498   Glucocorticoid Receptor Genetic Variants and Response to Fluoxetine in Major Depressive Disorder.

  29100174   The role of genetic variation in the glucocorticoid receptor (NR3C1) and mineralocorticoid receptor (NR3C2) in the association between cortisol response and cognition under acute stress.

  29526633   Association between allelic variants of the human glucocorticoid receptor gene and autoimmune diseases: A systematic review and meta-analysis.

  29761890   Glucocorticoid receptor gene variants and lower expression of NR3C1 are associated with cocaine use.

  29802709   Association Between NR3C1 Gene Polymorphisms and Toxicity Induced by Glucocorticoids Therapy in Saudi Children with Acute Lymphoblastic Leukemia.

  29879676   Genetic variation in the glucocorticoid receptor and psychopathology after dexamethasone administration in cardiac surgery patients.

  30210047   Pharmacogenomic markers of glucocorticoid response in the initial phase of remission induction therapy in childhood acute lymphoblastic leukemia.

  30999951   NR3C1 gene polymorphisms are associated with high-altitude pulmonary edema in Han Chinese.

  31022961   FKBP5 rs4713916: A Potential Genetic Predictor of Interindividual Different Response to Inhaled Corticosteroids in Patients with Chronic Obstructive Pulmonary Disease in a Real-Life Setting.

  31724909   Role of NR3C1 and GAS5 genes polymorphisms in multiple sclerosis.

  32032633   Dual biomarkers long non-coding RNA GAS5 and its target, NR3C1, contribute to acute myeloid leukemia.

  33019527   The Pathways between Cortisol-Related Regulation Genes and PTSD Psychotherapy.

  33562675   The Glucocorticoid Receptor Gene (NR3C1) 9β SNP Is Associated with Posttraumatic Stress Disorder.

  34298075   Glucocorticoid receptor Gene (NR3C1) Polymorphisms and Haplotypes in patients with congenital adrenal hyperplasia.

  34466443   Genetic Variant of Glucocorticoid Receptor Gene at rs41423247 and Its Association with Major Depressive Disorder: A Case-Control Study.

  34721069   The Glucocorticoid Receptor Polymorphism Landscape in Patients With Diamond Blackfan Anemia Reveals an Association Between Two Clinically Relevant Single Nucleotide Polymorphisms and Time to Diagnosis.

Serotonin transporter sert

In humans, the SLC6A4 gene encodes a protein referred to as both the sodium-dependent serotonin...

CYP21 deficiency

The inability to synthesize cortisol, known as congenital adrenal hyperplasia (CAH), is responsible...

Dopamine transporter genes

The membrane-bound protein called the dopamine transporter (DAT), also known as the...