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SNP information rs4880

Normal allele: AA

Polymorphism of antioxidant enzymes as risk factors for complications, leads to increased oxidative stress. Affects the level of selenium in serum.

Polymorphism rs4880 is related to topics like this:

Genetic haemochromatosis

Hereditary hemochromatosis is a genetic condition associated with severe liver disease and various...

Selenium dna repair

Selenium, an essential trace element for multiple cellular processes, was initially deemed...

DNA oxidation

Cancer may be linked to oxidative damage of DNA from various chemical and physical agents, but...

The mitochondria contain circular chromosomes known as mitochondrial DNA and are organelles...


Research and publications:

  8633092   On signal sequence polymorphisms and diseases of distribution.

  10425186   Polymorphisms in the SOD2 and HLA-DRB1 genes are associated with nonfamilial idiopathic dilated cardiomyopathy in Japanese.

  12624725   The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients.

  15591282   The mitochondrial superoxide dismutase A16V polymorphism in the cardiomyopathy associated with hereditary haemochromatosis.

  16385446   A testing framework for identifying susceptibility genes in the presence of epistasis

  16538174   Genotype-activity relationship for Mn-superoxide dismutase, glutathione peroxidase 1 and catalase in humans.

  16543247   Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma.

  16945136   Gene x Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study.

  17192491   A functional polymorphism in the manganese superoxide dismutase gene and diabetic nephropathy.

  17293864   A common coding variant in CASP8 is associated with breast cancer risk.

  17601350   A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

  17825092   Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography

  18191955   Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools

  18212354   Genes in glucose metabolism and association with spina bifida.

  18296681   Iron intake, oxidative stress-related genes (MnSOD and MPO) and prostate cancer risk in CARET cohort.

  18340529   A prospective study of genetic polymorphism in MPO, antioxidant status, and breast cancer risk

  18423055   Gene polymorphisms of superoxide dismutases and catalase in diabetes mellitus.

  18582155   Association of single nucleotide polymorphisms in SOD2, XRCC1 and XRCC3 with susceptibility for the development of adverse effects resulting from radiotherapy for prostate cancer.

  18676870   Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China

  18682580   Oxidative response gene polymorphisms and risk of adult brain tumors.

  18698231   Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.

  18704161   Genetic variation in an individual human exome.

  18781856   Genetic underpinnings of tardive dyskinesia: passing the baton to pharmacogenetics.

  19074884   Interaction between single nucleotide polymorphisms in selenoprotein P and mitochondrial superoxide dismutase determines prostate cancer risk.

  19423521   Genetic polymorphisms in nitric oxide synthase genes modify the relationship between vegetable and fruit intake and risk of non-Hodgkin lymphoma.

  19428448   The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old.

  19493484   [Association between SNPs in SOD2 and noise-induced hearing loss].

  19505917   Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors.

  19509150   A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide.

  19706356   Functional polymorphism in manganese superoxide dismutase and antioxidant status: their interactions on the risk of cervical intraepithelial neoplasia and cervical cancer.

  19753309   SOD2 gene polymorphisms in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.

  19754948   Evaluation of nine candidate genes in patients with normal tension glaucoma: a case control study.

  19778569   Oxidative stress in tardive dyskinesia: genetic association study and meta-analysis of NADPH quinine oxidoreductase 1 (NQO1) and Superoxide dismutase 2 (SOD2, MnSOD) genes.

  19863340   Influence of the polymorphism in candidate genes on late cardiac damage in patients treated due to acute leukemia in childhood.

  19946932   Lack of association of GPX1 and MnSOD genes with symptom severity and response to clozapine treatment in schizophrenia subjects.

  20043000   Association of SOD2, a mitochondrial antioxidant enzyme, with gray matter volume shrinkage in alcoholics.

  20082738   Inter-individual variation in DNA damage and base excision repair in young, healthy non-smokers: effects of dietary supplementation and genotype.

  20097730   Antioxidant genes, diabetes and dietary antioxidants in association with risk of pancreatic cancer.

  20378690   Genetic variants in selenoprotein genes increase risk of colorectal cancer.

  20444272   Gene polymorphisms against DNA damage induced by hydrogen peroxide in leukocytes of healthy humans through comet assay: a quasi-experimental study.

  20445800   Genetic Polymorphisms in Genes Related to Oxidative Stress (GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO, eNOS) and Survival of Rectal Cancer Patients after Radiotherapy.

  20477822   Single-nucleotide polymorphisms within the antioxidant defence system and associations with aggressive prostate cancer.

  20534900   SOD2 V16A SNP in the mitochondrial targeting sequence is associated with noise induced hearing loss in Chinese workers.

  20644561   A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer.

  20673164   Genetic association studies of antioxidant pathway genes and schizophrenia.

  20711808   Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists

  20728955   Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus.

  20872977   Mn-SOD and CuZn-SOD polymorphisms and interactions with risk factors in gastric cancer.

  20966810   Superoxide dismutase and nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase polymorphisms and pancreatic cancer risk.

  21048526   Doxorubicin pathways: pharmacodynamics and adverse effects.

  21052528   Polymorphisms in the selenoprotein S and 15-kDa selenoprotein genes are associated with altered susceptibility to colorectal cancer.

  21062213   Manganese superoxide dismutase dimorphism relationship with severity and prognosis in cardiogenic shock due to dilated cardiomyopathy.

  21072184   Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition.

  21181397   Association of the C47T polymorphism in SOD2 with diabetes mellitus and diabetic microvascular complications: a meta-analysis.

  21240526   Evaluation of the association studies of single nucleotide polymorphisms and hepatocellular carcinoma: a systematic review.

  21338322   Parameters of oxidative stress, DNA damage and DNA repair in type 1 and type 2 diabetes mellitus.

  21351093   Association of superoxide dismutases and NAD(P)H quinone oxidoreductases with prognosis of patients with breast carcinomas.

  21514219   Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence

  21567099   Estrogen metabolism genotypes, use of long-term hormone replacement therapy and risk of postmenopausal breast cancer.

  21595856   Genetic polymorphisms in antioxidative enzymes are associated to forced expiratory volume in 1 s (FEV1) in smokers independently of asthma.

  21637495   Dietary carotenoid-rich oil supplementation improves exercise-induced anisocytosis in runners: influences of haptoglobin, MnSOD (Val9Ala), CAT (21A/T) and GPX1 (Pro198Leu) gene polymorphisms in dilutional pseudoanemia (sports anemia).

  21708280   Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis

  21728034   Methamphetamine-associated psychosis.

  21741706   Correlation of CYP2B6, CYP2C19, ABCC4 and SOD2 genotype with outcomes in allogeneic blood and marrow transplant patients.

  21756849   The SOD2 C47T polymorphism influences NAFLD fibrosis severity: evidence from case-control and intra-familial allele association studies.

  21795425   Genetic variation in myeloperoxidase modifies the association of serum α-tocopherol with aggressive prostate cancer among current smokers.

  21869864   An integrative genomics approach to biomarker discovery in breast cancer.

  21894447   Are centenarians genetically predisposed to lower disease risk?

  21915362   Sequence variants in antioxidant defense and DNA repair genes, dietary antioxidants, and pancreatic cancer risk.

  21982398   Serum levels of selenium and smoking habits at age 50 influence long term prostate cancer risk; a 34 year ULSAM follow-up.

  22068340   Associations between functional polymorphisms in antioxidant defense genes and urinary oxidative stress biomarkers in healthy, premenopausal women.

  22072939   Manganese superoxide dismutase: guardian of the powerhouse.

  22144047   A single-nucleotide polymorphism in the methylene tetrahydrofolate reductase (MTHFR) gene is associated with risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy.

  22189546   Association between genetics of diabetes, coronary artery disease, and macrovascular complications: exploring a common ground hypothesis.

  22206979   Genetic variants in antioxidant genes are associated with sperm DNA damage and risk of male infertility in a Chinese population.

  22287936   Pharmacogenetics of antipsychotic treatment response and side effects.

  22303384   Whole genome sequences of a male and female supercentenarian, ages greater than 114 years.

  22424094   Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: a case control study.

  22509112   Genetic associations in polypoidal choroidal vasculopathy: a systematic review and meta-analysis.

  22517484   Clinical significance of SOD2 and GSTP1 gene polymorphisms in Chinese patients with gastric cancer.

  22531667   PM10-induced hospital admissions for asthma and chronic obstructive pulmonary disease: the modifying effect of individual characteristics.

  22537351   Association of single nucleotide polymorphisms in the genes ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with risk of severe erythema after breast conserving radiotherapy.

  22564066   Heterocyclic aromatic amine [HCA] intake and prostate cancer risk: effect modification by genetic variants.

  22574884   Genetic polymorphisms of antioxidant enzymes as risk factors for oxidative stress-associated complications in preterm infants.

  22610343   Genetic variants in antioxidant genes are associated with diisocyanate-induced asthma.

  22615781   Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study.

  22661588   Antioxidant enzyme polymorphisms and neuropsychological outcomes in medulloblastoma survivors: a report from the Childhood Cancer Survivor Study.

  22824134   Polymorphism in glutamate cysteine ligase catalytic subunit (GCLC) is associated with sulfamethoxazole-induced hypersensitivity in HIV/AIDS patients.

  22958044   Genetic polymorphisms of antioxidant enzymes in preterm infants.

  22987024   Aromatic DNA adducts and number of lung cancer risk alleles in Map-Ta-Phut Industrial Estate workers and nearby residents.

  22992668   Pharmacogenomics knowledge for personalized medicine.

  23142385   Higher frequency of septic shock in septic patients with the 47C allele (rs4880) of the SOD2 gene.

  23175176   Variation in PAH-related DNA adduct levels among non-smokers: the role of multiple genetic polymorphisms and nucleotide excision repair phenotype.

  23259684   Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case-control study.

  23261794   Influence of genetic polymorphisms on the association between phthalate exposure and pulmonary function in the elderly.

  23500038   A functional and genetic analysis of SOD2 promoter variants and their contribution to age-related hearing loss.

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