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SNP information rs34536443

Normal allele: GG

A major variant in the TYK2 gene that significantly increases (90-fold) the risk of developing TB according to studies if a carrier of the minor homozygous genotype is exposed to TB.

Polymorphism rs34536443 is related to topics like this:


Research and publications:

  18270328   Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.

  19293837   Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor.

  19865102   Multiple sclerosis susceptibility alleles in African Americans.

  19888296   A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis.

  20186855   What role for genetics in the prediction of multiple sclerosis?

  20362272   Evidence for polygenic susceptibility to multiple sclerosis--the shape of things to come.

  20392289   Genetic associations in type I interferon related pathways with autoimmunity.

  20405052   The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.

  21140222   Meta-analysis of TYK2 gene polymorphisms association with susceptibility to autoimmune and inflammatory diseases.

  21280076   Aggregation of multiple sclerosis genetic risk variants in multiple and single case families.

  21354972   Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility.

  23000200   TYK2 rs34536443 polymorphism is associated with a decreased susceptibility to endometriosis-related infertility.

  23730204   Progress in multiple sclerosis genetics.

  23886662   A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis.

  24968701   CYP19 gene variant confers susceptibility to endometriosis-associated infertility in Chinese women.

  25233071   Allele-specific network reveals combinatorial interaction that transcends small effects in psoriasis GWAS.

  25651891   Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis.

  25741868   Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

  25849893   TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.

  26255310   Identifying a novel locus for psoriatic arthritis.

  26338038   Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway.

  26765264   The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells.

  26843965   Identification of rheumatoid arthritis biomarkers based on single nucleotide polymorphisms and haplotype blocks: A systematic review and meta-analysis.

  27109064   Major histocompatibility complex harbors widespread genotypic variability of non-additive risk of rheumatoid arthritis including epistasis.

  29728633   The psoriasis-protective TYK2 I684S variant impairs IL-12 stimulated pSTAT4 response in skin-homing CD4+ and CD8+ memory T-cells.

  30327483   Phenome-wide association studies across large population cohorts support drug target validation.

  30423093   Insights on the alteration of functionality of a tyrosine kinase 2 variant: a molecular dynamics study.

  30643196   POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33.

  30740104   The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets.

  30888520   Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes.

  30988702   Defining the genetic profile of endometriosis.

  31057722   Single Nucleotide Polymorphism of TYK2 Gene and Susceptibility to Rheumatoid Arthritis in Iranian Population.

  31118190   Identification of rare coding variants in TYK2 protective for rheumatoid arthritis in the Japanese population and their effects on cytokine signalling.

  31434951   Catalytically Impaired TYK2 Variants are Protective Against Childhood- and Adult-Onset Systemic Lupus Erythematosus in Mexicans.

  32831971   Investigating the GWAS-Implicated Loci for Rheumatoid Arthritis in the Pakistani Population.

  33949620   Association of TYK2 polymorphisms with autoimmune diseases: A comprehensive and updated systematic review with meta-analysis.

  34199962   Characterization of Rheumatoid Arthritis Risk-Associated SNPs and Identification of Novel Therapeutic Sites Using an In-Silico Approach.

  35088123   Genetics of rheumatoid arthritis.

  35470158   Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset.

  35747941   Association of germline TYK2 variation with lung cancer and non-Hodgkin lymphoma risk.