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SNP information rs324650

RS324650

Normal allele: TT

Variation in the muscarinic acetylcholine receptor M2 (CHRM2) gene is associated with alcohol dependence and major depressive disorder.

Polymorphism rs324650 is related to topics like this:

Alcoholism genes

Although alcohol is widely consumed, excessive use can lead to serious physical, psychological, and...

Depression is it genetic

Depression, also referred to as major depression or major depressive disorder, is a psychiatric...

Research and publications:

  15229186   Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome.

  17081262   Association between the CHRM2 gene and intelligence in a sample of 304 Dutch families.

  17373692   No evidence for association between 19 cholinergic genes and bipolar disorder.

  17996044   Exploring the functional role of the CHRM2 gene in human cognition: results from a dense genotyping and brain expression study.

  18634760   Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes.

  19181679   Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder.

  19644963   Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction.

  20351719   Genetic variation in cholinergic muscarinic-2 receptor gene modulates M2 receptor binding in vivo and accounts for reduced binding in bipolar disorder.

  21176104   Association of CHRM2 polymorphisms with severity of alcohol dependence.

  21302343   The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects.

  21441226   CHRM2, parental monitoring, and adolescent externalizing behavior: evidence for gene-environment interaction.

  21883161   Differential susceptibility to adolescent externalizing trajectories: examining the interplay between CHRM2 and peer group antisocial behavior.

  23927501   Why it is hard to find genes associated with social science traits: theoretical and empirical considerations.

  24755993   Therapygenetics in mindfulness-based cognitive therapy: do genes have an impact on therapy-induced change in real-life positive affective experiences?

  26044620   Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction.

  35140610   Genetic Factors Associated With Tardive Dyskinesia: From Pre-clinical Models to Clinical Studies.

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Myasthenia gravis is a condition that weakens the skeletal muscles, which are responsible for...

Heart disease genetic

Although genetics can be a major factor in the development of certain heart diseases, individuals...

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