SNP information rs324420

Research and publications:

  12060782   A missense mutation in human fatty acid amide hydrolase associated with problem drug use.

  15254019   Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use.

  15986317   Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease.

  16882734   Genetic predictors for acute experimental cold and heat pain sensitivity in humans

  16972078   The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction.

  17216208   The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites.

  17847002   An LRP8 variant is associated with familial and premature coronary artery disease and myocardial infarction.

  17991615   Rapid screening for potentially relevant polymorphisms in the human fatty acid amide hydrolase gene using Pyrosequencing.

  18705688   Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes.

  19002671   Intermediate cannabis dependence phenotypes and the FAAH C385A variant: an exploratory analysis.

  19014633   Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa.

  19053981   The role of fatty acid hydrolase gene variants in inflammatory bowel disease.

  19165169   Variants in the CNR1 and the FAAH genes and adiposity traits in the community.

  19335651   Candidate genes for cannabis use disorders: findings, challenges and directions.

  19659925   Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects.

  19890266   More aroused, less fatigued: fatty acid amide hydrolase gene polymorphisms influence acute response to amphetamine.

  19958092   Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descent.

  20010552   Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues.

  20033240   Eating disorders: the current status of molecular genetic research.

  20044928   Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity.

  20054193   Evaluating the association of FAAH common gene variation with childhood, adult severe obesity and type 2 diabetes in the French population.

  20080186   Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression.

  20631561   Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain.

  21118518   Population sequencing of two endocannabinoid metabolic genes identifies rare and common regulatory variants associated with extreme obesity and metabolite level.

  21333900   The role of genetics in IBS

  21477106   Association of genetic variation in cannabinoid mechanisms and gastric motor functions and satiation in overweight and obesity.

  21798285   Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors.

  21803011   Pharmacogenetic trial of a cannabinoid agonist shows reduced fasting colonic motility in patients with nonconstipated irritable bowel syndrome.

  22068813   The fatty acid amide hydrolase (FAAH) gene variant rs324420 AA/AC is not associated with weight loss in a 1-year lifestyle intervention for obese children and adolescents.

  22123166   Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence.

  22288893   Randomized pharmacodynamic and pharmacogenetic trial of dronabinol effects on colon transit in irritable bowel syndrome-diarrhea.

  22688188   Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity.

  22832737   Fatty-acid amide hydrolase polymorphisms and post-traumatic stress disorder after penetrating brain injury.

  23048207   Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin.

  23333123   Genetic variation in the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and their influence on weight loss and insulin resistance under a high monounsaturated fat hypocaloric diet.

  23556448   Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population.

  23793356   Neuroimaging in psychiatric pharmacogenetics research: the promise and pitfalls.

  23799528   Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies.

  24172113   Impulsivity, variation in the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes, and marijuana-related problems.

  24180398   Endocannabinoid signaling in the etiology and treatment of major depressive illness.

  24407958   Risky alcohol consumption in young people is associated with the fatty acid amide hydrolase gene polymorphism C385A and affective rating of drug pictures.

  24444427   Association of cannabinoid type 1 receptor and fatty acid amide hydrolase genetic polymorphisms in Chinese patients with irritable bowel syndrome.

  25045619   The Genetics, Neurogenetics and Pharmacogenetics of Addiction.

  25558980   Novel associations between FAAH genetic variants and postoperative central opioid-related adverse effects.

  25731744   FAAH genetic variation enhances fronto-amygdala function in mouse and human.

  26036940   The fatty acid amide hydrolase C385A variant affects brain binding of the positron emission tomography tracer [11C]CURB.

  26189450   Genetic Moderation of Stress Effects on Corticolimbic Circuitry.

  26272535   The placebo effect: From concepts to genes.

  26806592   Interactions between dietary oil treatments and genetic variants modulate fatty acid ethanolamides in plasma and body weight composition.

  26808012   Effect of endocannabinoid degradation on pain: role of FAAH polymorphisms in experimental and postoperative pain in women treated for breast cancer.

  26857901   Involvement of Endocannabinoids in Alcohol "Binge" Drinking: Studies of Mice with Human Fatty Acid Amide Hydrolase Genetic Variation and After CB1 Receptor Antagonists.

  26923505   Interactions Between Anandamide and Corticotropin-Releasing Factor Signaling Modulate Human Amygdala Function and Risk for Anxiety Disorders: An Imaging Genetics Strategy for Modeling Molecular Interactions.

  27074158   Dose-dependent cannabis use, depressive symptoms, and FAAH genotype predict sleep quality in emerging adults: a pilot study.

  27140937   Genetic variants associated with physical and mental characteristics of the elite athletes in the Polish population.

  27345297   Fatty Acid Amide Hydrolase Binding in Brain of Cannabis Users: Imaging With the Novel Radiotracer [(11)C]CURB.

  27394933   Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans.

  27642547   Genetic and Environmental Factors Associated with Cannabis Involvement.

  27895608   Genetic Consideration of Schizotypal Traits: A Review.

  27977335   Fatty acid amide hydrolase-morphine interaction influences ventilatory response to hypercapnia and postoperative opioid outcomes in children.

  28150397   Severity of alcohol dependence is associated with the fatty acid amide hydrolase Pro129Thr missense variant.

  28534260   Pharmacogenetics of Cannabinoids.

  29652995   [Association of polymorphisms of NAPE-PLD and FAAH genes with schizophrenia in Chinese Han population].

  29967158   Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance.

  30126012   FAAH variant Pro129Thr modulates subjective effects produced by cocaine administration.

  30129173   Genetic polymorphisms of the endocannabinoid system in obesity and diabetes.

  30949563   FAAH genotype, CRFR1 genotype, and cortisol interact to predict anxiety in an aging, rural Hispanic population: A Project FRONTIER study.

  31013550   Acute effects of cannabinoids on addiction endophenotypes are moderated by genes encoding the CB1 receptor and FAAH enzyme.

  31085105   Genetic Variants Associated with Cancer Pain and Response to Opioid Analgesics: Implications for Precision Pain Management.

  31184938   CNR1 and FAAH variation and affective states induced by marijuana smoking.

  31335650   OPRM1 rs1799971, COMT rs4680, and FAAH rs324420 genes interact with placebo procedures to induce hypoalgesia.

  31552390   Placebo effects and the molecular biological components involved.

  31789429   FAAH levels and its genetic polymorphism association with susceptibility to methamphetamine dependence.

  31910433   Lower brain fatty acid amide hydrolase in treatment-seeking patients with alcohol use disorder: a positron emission tomography study with [C-11]CURB.

  31914367   HYPNOTIZABILITY-RELATED FAAH C385A POLYMORPHISM: POSSIBLE ENDOCANNABINOID CONTRIBUTION TO SUGGESTION-INDUCED ANALGESIA.

  31960544   Fatty acid amide hydrolase is lower in young cannabis users.

  32398646   Do AKT1, COMT and FAAH influence reports of acute cannabis intoxication experiences in patients with first episode psychosis, controls and young adult cannabis users?

  32521537   Elevated fatty acid amide hydrolase in the prefrontal cortex of borderline personality disorder: a [(11)C]CURB positron emission tomography study.

  32576619   Effects of TPH2 gene variation and childhood trauma on the clinical and circuit-level phenotype of functional movement disorders.

  32807182   Clinical, genomics and networking analyses of a high-altitude native American Ecuadorian patient with congenital insensitivity to pain with anhidrosis: a case report.

  33031748   A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos.

  33437986   Heritability and family-based GWAS analyses of the N-acyl ethanolamine and ceramide plasma lipidome.

  33460184   Association of the Fatty Acid Amide Hydrolase C385A Polymorphism With Alcohol Use Severity and Coping Motives in Heavy-Drinking Youth.

  33723207   Fear extinction learning and anandamide: an fMRI study in healthy humans.

  33729738   Fatty acid amide hydrolase binding is inversely correlated with amygdalar functional connectivity: a combined positron emission tomography and magnetic resonance imaging study in healthy individuals.

  33763108   Whole Genome Interpretation for a Family of Five.

  34051704   A common genetic variant in fatty acid amide hydrolase is linked to alterations in fear extinction neural circuitry in a racially diverse, nonclinical sample of adults.

  34151472   Cannabinoid polymorphisms interact with plasma endocannabinoid levels to predict fear extinction learning.

  34171108   Cannabinoid receptor type 2 gene is associated with comorbidity of schizophrenia and cannabis dependence and fatty acid amide hydrolase gene is associated with cannabis dependence in the Spanish population.

  34566715   FAAH and CNR1 Polymorphisms in the Endocannabinoid System and Alcohol-Related Sleep Quality.

  34871222   Influence of genetic variants of opioid-related genes on opioid-induced adverse effects in patients with lung cancer: A STROBE-compliant observational study.

  34893921   FAAH polymorphism (rs324420) modulates extinction recall in healthy humans: an fMRI study.

  34916909   Genetic Variants of Fatty Acid Amide Hydrolase Modulate Acute Inflammatory Responses to Colitis in Adult Male Mice.

  34952353   The influence of FAAH genetic variation on physiological, cognitive, and neural signatures of fear acquisition and extinction learning in women with PTSD.

  35105857   Circulating endocannabinoids and genetic polymorphisms as predictors of posttraumatic stress disorder symptom severity: heterogeneity in a community-based cohort.

  35327588   Biomarkers of the Endocannabinoid System in Substance Use Disorders.

  35387194   Personalized Dietary Recommendations Based on Lipid-Related Genetic Variants: A Systematic Review.

  35537858   Cannabidiol for Functional Dyspepsia With Normal Gastric Emptying: A Randomized Controlled Trial.

  35944262   Impact of Childhood Trauma Exposure, Genetic Variation in Endocannabinoid Signaling, and Anxiety on Frontolimbic Pathways in Children.

  36099111   Association of Alcohol Use Disorder Risk With ADH1B, DRD2, FAAH, SLC39A8, GCKR, and PDYN Genetic Polymorphisms.