SNP information rs279858

Research and publications:

  15024690   Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations.

  16080114   Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism.

  18005236   Human gamma-aminobutyric acid A receptor alpha2 gene moderates the acute effects of alcohol and brain mRNA expression.

  18482426   Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study.

  18634760   Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes.

  18727688   The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sample.

  18818659   GABRG1 and GABRA2 as independent predictors for alcoholism in two populations.

  19207358   Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence.

  19335651   Candidate genes for cannabis use disorders: findings, challenges and directions.

  19487630   Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring.

  20202923   A genome-wide association study of alcohol dependence.

  20482509   Pharmacogenetics of alcohol and alcohol dependence treatment.

  20549395   Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies

  21118274   Role of GABRA2 in moderating subjective responses to alcohol.

  21225419   Gene-environment interactions: early life stress and risk for depressive and anxiety disorders.

  21483437   Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism.

  21808609   Components of cross-frequency modulation in health and disease.

  21919924   GABRG1 and GABRA2 variation associated with alcohol dependence in African Americans.

  22011682   Pharmacogenetic approaches to the treatment of alcohol addiction.

  22048727   Genetics of GABAergic signaling in nicotine and alcohol dependence.

  22129841   GABRA2 and KIBRA genotypes predict early relapse to substance use.

  22501025   GABRA2 markers moderate the subjective effects of alcohol.

  22555154   Gamma-aminobutyric acid A receptor, α-2 (GABRA2) variants as individual markers for alcoholism: a meta-analysis.

  22806211   The genetics of addiction-a translational perspective.

  22978509   Convergence of genome-wide association and candidate gene studies for alcoholism.

  24136292   Association of gamma-aminobutyric acid A receptor α2 gene (GABRA2) with alcohol use disorder.

  24166645   The GABRA2 variant is associated with increased stimulation and a “high” after drinking alcohol.

  24557088   Dutasteride reduces the sedative effects of alcohol in men in vitro and reduces alcohol consumption in the wild.

  24975023   Effect of GABRA2 genotype on development of incentive-motivation circuitry in a sample enriched for alcoholism risk.

  25045619   The Genetics, Neurogenetics and Pharmacogenetics of Addiction.

  25514066   Association study of GABAA α2 receptor subunit gene variants in antipsychotic-associated weight gain.

  25797587   Susceptibility effects of GABA receptor subunit alpha-2 (GABRA2) variants and parental monitoring on externalizing behavior trajectories: Risk and protection conveyed by the minor allele.

  25804982   Mechanisms in the relation between GABRA2 and adolescent externalizing problems.

  26087834   Adaptation of Subjective Responses to Alcohol is Affected by an Interaction of GABRA2 Genotype and Recent Drinking.

  26116794   Association of GABAA receptor α2 subunit gene (GABRA2) with alcohol dependence-related aggressive behavior.

  26250693   GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures.

  26845260   Temperament and externalizing behavior as mediators of genetic risk on adolescent substance use.

  27117237   Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals.

  28237505   Stressful life events increase aggression and alcohol use in young carriers of the GABRA2 rs279826/rs279858 A-allele.

  28534260   Pharmacogenetics of Cannabinoids.

  29131352   GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose-Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers.

  29992684   A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults.

  30061709   GABRA2 rs279858-linked variants are associated with disrupted structural connectome of reward circuits in heroin abusers.

  32602428   A systematic review of gene-by-intervention studies of alcohol and other substance use.

  35943164   Study of the Association of Single Nucleotide Polymorphisms in Candidate Genes With Sevoflurane.