SNP information rs2274223

Research and publications:

  16385451   A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

  20729852   A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.

  21427165   Genetic variants at 1q22 and 10q23 reproducibly associated with gastric cancer susceptibility in a Chinese population.

  21689432   Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck.

  21837401   Genetic variation in PLCE1 is associated with gastric cancer survival in a Chinese population.

  22203178   Putatively functional PLCE1 variants and susceptibility to esophageal squamous cell carcinoma (ESCC): a case-control study in eastern Chinese populations.

  22323360   Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies.

  22412849   Potentially functional variants of PLCE1 identified by GWASs contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.

  22507220   Epidemiologic differences in esophageal cancer between Asian and Western populations.

  22740136   Association of 10q23 with colorectal cancer in a Chinese population.

  22744421   Replication study of PLCE1 and C20orf54 polymorphism and risk of esophageal cancer in a Chinese population.

  22805490   Genetic variation in C20orf54, PLCE1 and MUC1 and the risk of upper gastrointestinal cancers in Caucasian populations.

  22865593   Distinct genetic association at the PLCE1 locus with oesophageal squamous cell carcinoma in the South African population.

  23151416   Genetic variants at 10q23 are associated with risk of head and neck cancer in a Chinese population.

  23222411   GWAS-uncovered SNPs in PLCE1 and RFT2 genes are not implicated in Dutch esophageal adenocarcinoma and squamous cell carcinoma etiology.

  23390063   A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis.

  23629646   Epidemiology of esophageal cancer in Japan and China.

  23688607   Novel functional variants locus in PLCE1 and susceptibility to esophageal squamous cell carcinoma: based on published genome-wide association studies in a central Chinese population.

  23797815   PLCE1 rs2274223 A>G polymorphism and cancer risk: a meta-analysis.

  23975622   Association of potentially functional genetic variants of PLCE1 with gallbladder cancer susceptibility in north Indian population.

  23981775   Multiple polymorphisms within the PLCE1 are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh population.

  24127316   Heterozygote of PLCE1 rs2274223 increases susceptibility to human papillomavirus infection in patients with esophageal carcinoma among the Kazakh populations.

  24152165   Replication of results of genome-wide association studies on esophageal squamous cell carcinoma susceptibility loci in a Korean population.

  24254309   Common genetic variants at 1q22 and 10q23 and gastric cancer susceptibility in a Korean population.

  24496148   Association between phospholipase C epsilon gene (PLCE1) polymorphism and colorectal cancer risk in a Chinese population.

  24737582   PLCE1 rs2274223 polymorphism contributes to risk of esophageal cancer: evidence based on a meta-analysis.

  24863943   A multigenic approach to evaluate genetic variants of PLCE1, LXRs, MMPs, TIMP, and CYP genes in gallbladder cancer predisposition.

  24874112   Novel functional variants locus in PLCE1 and susceptibility to digestive tract cancer in the Chinese population: a meta-analysis.

  24884822   A replication study confirms the association of GWAS-identified SNPs at MICB and PLCE1 in Thai patients with dengue shock syndrome.

  25133033   Epidemiological studies of esophageal cancer in the era of genome-wide association studies.

  25139097   Role of novel and GWAS originated PLCE1 genetic variants in susceptibility and prognosis of esophageal cancer patients in northern Indian population.

  25614244   Association between PLCE1 rs2274223 A > G polymorphism and cancer risk: proof from a meta-analysis.

  25658482   Associations of genetic variants in the PSCA, MUC1 and PLCE1 genes with stomach cancer susceptibility in a Chinese population.

  25687184   Genome-wide association pathway analysis to identify candidate single nucleotide polymorphisms and molecular pathways for gastric adenocarcinoma.

  25731870   Genetic variation and gastric cancer risk: a field synopsis and meta-analysis.

  25741868   Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology.

  26078291   Genetic variant PLCE1 rs2274223 and gastric cancer: more to be explored?

  26125444   Family history of cancer and the risk of squamous cell carcinoma of oesophagus: a case-control study in Kashmir, India.

  26176862   Evaluating the Association of Eight Polymorphisms with Cancer Susceptibility in a Han Chinese Population.

  26683024   Comparison of Genetic Variants in Cancer-Related Genes between Chinese Hui and Han Populations.

  26760766   Association of nucleotide excision repair pathway gene polymorphisms with gastric cancer and atrophic gastritis risks.

  26770579   Genetic variants at 6p21, 10q23, 16q21 and 22q12 are associated with esophageal cancer risk in a Chinese Han population.

  26891331   Impact of DCC (rs714) and PSCA (rs2294008 and rs2976392) Gene Polymorphism in Modulating Cancer Risk in Asian Population.

  27038471   In silico transcriptional regulation and functional analysis of dengue shock syndrome associated SNPs in PLCE1 and MICB genes.

  27061602   Cytochrome P450 1A1 gene polymorphisms and digestive tract cancer susceptibility: a meta-analysis.

  27127881   Risk prediction for early-onset gastric carcinoma: a case-control study of polygenic gastric cancer in Han Chinese with hereditary background.

  27186304   Genome-wide association study identified PLCE1- rs2797992 and EGFR- rs6950826 were associated with TP53 expression in the HBV-related hepatocellular carcinoma of Chinese patients in Guangxi.

  27383248   Genetic Variations in Phospholipase C-epsilon 1 (PLCE1) and Susceptibility to Colorectal Cancer Risk.

  28418898   PLCE1 polymorphisms and expression combined with serum AFP level predicts survival of HBV-related hepatocellular carcinoma patients after hepatectomy.

  28424424   Leukocyte telomere length-related genetic variants in ACYP2 contribute to the risk of esophageal carcinoma in Chinese Han population.

  28652652   Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update.

  29387411   Phospholipase C ε-1 gene polymorphisms and prognosis of esophageal cancer patients from a high-incidence region in northern China.

  29673983   Population genetics-informed meta-analysis in seven genes associated with risk to dengue fever disease.

  29983348   Evaluation of GWAS-Identified Genetic Variants for Gastric Cancer Survival.

  30202044   Gastric cancer may share genetic predisposition with esophageal squamous cell carcinoma in Chinese populations.

  30619753   Single Nucleotide Polymorphisms in PLCE1 for Cancer Risk of Different Types: A Meta-Analysis.

  30666517   An Association and Meta-Analysis of Esophageal Squamous Cell Carcinoma Risk Associated with PLCE1 rs2274223, C20orf54 rs13042395 and RUNX1 rs2014300 Polymorphisms.

  30753320   Association of genetic variants in CHEK2 with oesophageal squamous cell carcinoma in the South African Black population.

  30784231   Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta-analysis.

  30793520   Cumulative evidence for association between genetic polymorphisms and esophageal cancer susceptibility: A review with evidence from meta-analysis and genome-wide association studies.

  30931333   PLCE1 Polymorphisms and Risk of Esophageal and Gastric Cancer in a Northwestern Chinese Population.

  31428123   Systematic Review of Genetic Factors in the Etiology of Esophageal Squamous Cell Carcinoma in African Populations.

  31516756   Genetic polymorphisms and gastric cancer risk: a comprehensive review synopsis from meta-analysis and genome-wide association studies.

  31649800   The Correlation between Phospholipase C Epsilon (PLCE1) Gene Polymorphisms and Risk of Gastric Adenocarcinoma in Iranian Population.

  31767616   Estimation of associations between 10 common gene polymorphisms and gastric cancer: evidence from a meta-analysis.

  32777176   Predictive model for risk of gastric cancer using genetic variants from genome-wide association studies and high-evidence meta-analysis.

  32802164   A multinational review: Oesophageal cancer in low to middle-income countries.

  32869542   Genetic variants in GHR and PLCE1 genes are associated with susceptibility to esophageal cancer.

  33162810   The PLCE1 rs2274223 variant is associated with the risk of laryngeal squamous cell carcinoma.

  34046701   Independent and opposing associations of dietary phytosterols intake and PLCE1 rs2274223 polymorphisms on esophageal squamous cell carcinoma risk.

  34491229   Identification and epidemiological evaluation of gastric cancer risk factors: based on a field synopsis and meta-analysis in Chinese population.

  34531897   PLCE1 Polymorphisms Are Associated With Gastric Cancer Risk: The Changes in Protein Spatial Structure May Play a Potential Role.